The Evolution of Axial Spondyloarthritis During 12-Month Follow-Up Study of a Corsar Cohort

Эрдес, Ш. Ф.; Дубинина, Т. В.; Румянцева, О. А.; Дёмина, А. Б.; Gubar, E.; Румянцева, Д. Г.

doi:10.14412/1995-4484-2016-1s-55-59

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Результаты когортных наблюдений не выявили принципиальных различий ме-жду пациентами с нр-аксСпА и АС [25,26]. В связи с этим подходы к лечению нр-аксСпА и АС не различа-ются.…”

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Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

Гайдукова¹,

Ребров²,

Лапшина³

et al. 2017

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В статье представлены рекомендации по лекарственной терапии аксиальных спондилоартритов, разработан-ные Экспертной группой по изучению спондилоартритов (ЭкСпА). Рекомендации описывают тактику веде-ния пациентов в наиболее частых клинических ситуациях, направленную на обеспечение максимальной эф-фективности и безопасности лечения. Ключевые слова: спондилоартриты; аксиальные спондилоартриты; анкилозирующий спондилит; болезнь Бехтерева; нестероидные противовоспалительные препараты; ингибиторы фактора некроза опухоли α; ин-гибиторы интерлейкина 17; безопасность терапии. Для ссылки: Гайдукова ИЗ, Ребров АП, Лапшина СА и др. Применение нестероидных противовоспали-тельных препаратов и генно-инженерных биологических препаратов для лечения аксиальных спондилоар-тритов. Рекомендации Экспертной группы по изучению спондилоартритов при Общероссийской общест-венной организации «Ассоциация ревматологов России». Научно-практическая ревматология. 2017;55(5):474-484. The paper gives recommendations for the drug therapy of axial spondyloarthritides, which have been developed by the Spondyloarthritis Study Group of Experts. The recommendations describe the patient management tactic in the most common clinical situations, which is aimed at maximizing the efficacy and safety of treatment. Key words: spondyloarthritides; axial spondyloarthritides; ankylosing spondylitis; Bechterew's disease; nonsteroidal anti-inflammatory drugs; tumor necrosis factor-α inhibitors; interleukin-17 inhibitors; safety of therapy. For reference: Gaidukova IZ, Rebrov AP, Lapshina SA, et al. Use of nonsteroidal anti-inflammatory drugs and biological agents for the treatment of axial spondyloarthritides. USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND BIOLOGICAL AGENTS FOR THE TREATMENT OF AXIAL SPONDYLOARTHRITIDES. RECOMMENDATIONS OF THE SPONDYLOARTHRITIS STUDY GROUP OF EXPERTS, ALL-RUSSIAN PUBLIC ORGANIZATION «THE ASSOCIATION OF RHEUMATOLOGY

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Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

Гайдукова¹,

Ребров²,

Лапшина³

et al. 2017

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“…Долгое время АС считался «мужской» болезнью: еще в начале XXI в. бытовало мнение, что доля женщин составляет не более 30% больных АС [5], и это, вероятно, обусловливало недостаточный интерес исследователей к вопросу беременности при данном заболевании. Однако в последнее время, с развитием учения о СпА, особенно с выделением их ранней нерентгенологической стадии, АС у женщин диагностируется чаще и соотношение мужчин и женщин, у которых был выявлен АС, изменилось и приближается к 1,5:1 [6,7].…”

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Ankylosing Spondylitis and Pregnancy: Data From a Pilot Study Based on a Questionnaire Survey of Patients

Гандалоева¹,

Кричевская²,

Дубинина³

et al. 2018

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“…Поскольку эволюция аксСпА слабо изучена, этому вопросу в последнее время уделяется все больше внимания. В нескольких исследованиях сравнивались клинические проявления АС и нр-аксСпА [5][6][7][8][9]. Было показано, что они сопоставимы между собой в отношении активности болезни, выраженности боли и влияния на качество жизни.…”

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Impact of the Frequency of Using Nonsteroidal Anti-Inflammatory Drugs on the Radiographic Progression of Sacroiliitis in Patients With Early Axial Spondyloarthritis

Румянцева¹,

Dubinina²,

Эрдес³

2018

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Objective: to compare the impact of continuous or on-demand use of nonsteroidal anti-inflammatory drugs (NSAIDs) on the activity and radiographic progression of early axial spondyloarthritis (axSpA).Subjects and methods. The investigation enrolled patients from the early spondyloarthritis cohort who met the 2009 Assessment of Spondyloarthritis International Society (ASAS) criteria for axSpA. This analysis included 68 patients who had been followed up for at least 24 months. The mean age at the time of inclusion in the investigation was 28.5±5.8 years; the mean disease duration was 24.1±15.4 months; 63 (92.6%) patients were HLA-B27-positive. The patients were divided into two groups: 1) 35 patients used NSAIDs at maximum therapeutic doses continuously during the follow-up period; 2) 33 patients received these drugs on-demand, depending on the presence and severity of back pain.Results and discussion. After 2-year follow-up, the median stage of radiographic sacroiliitis (SI) in Group 1 was unchanged and remained equal to 4; that in Group 2 in this period significantly increased from 3 to 4 scores (p < 0.05). At baseline, the patient groups did not differ in C-reactive protein (CRP) levels, the Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP), and the Bath Ankylosing Spondylitis Functional Index (BASFI); however, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was higher in Group 1 (p < 0.05). The number of patients with active SI, as evidenced by magnetic resonance imaging (MRI), and the degree of its severity did not differ significantly between groups. After 2 years, all the patients retained low disease activity according to ASDAS-CRP, BASDAI, and CRP levels; and these measures did not differ significantly between groups either; the BASFI became higher in Group 1. MRI findings indicated that the number of patients with active SI decreased, but no differences were found between the groups.Conclusion. In patients with early axSpA, the continuous intake of NSAIDs can slow radiographic progression to a greater extent than their on-demand use.

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The Evolution of Axial Spondyloarthritis During 12-Month Follow-Up Study of a Corsar Cohort

Cited by 3 publications

References 16 publications

Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

Ankylosing Spondylitis and Pregnancy: Data From a Pilot Study Based on a Questionnaire Survey of Patients

Impact of the Frequency of Using Nonsteroidal Anti-Inflammatory Drugs on the Radiographic Progression of Sacroiliitis in Patients With Early Axial Spondyloarthritis

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