The Ever-Expanding Clinical Spectrum of Tuberculosis

Franco‐Paredes, Carlos; Agudelo, Carlos A.

doi:10.1097/00124743-200202000-00001

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…More than 95% of these deaths occur in the developing world. 1,2 The three major infectious disease killers are HIV/AIDS, tuberculosis (TB), and malaria. In 1993 the World Health Organization (WHO) declared TB a global emergency due to its medical, social, and economic consequences.…”

Section: Introductionmentioning

confidence: 99%

Vaccination strategies to prevent tuberculosis in the new millennium: from BCG to new vaccine candidates

Franco‐Paredes

Rouphael

Rı́o

et al. 2006

International Journal of Infectious Diseases

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Current global control efforts targeting tuberculosis (TB) include the treatment of latent TB infection, case detection and treatment with directly observed therapy short-course (DOTS), and BCG (bacille Calmette-Guérin) vaccination. However, BCG has been found to decrease only childhood TB morbidity and mortality but has a very limited effect in the transmission dynamics of the infection. These limitations of BCG are the driving force for the development of new TB vaccines. New TB vaccine candidates have entered clinical evaluation and many more are in the pipeline to undergo clinical testing. New vaccine candidates may offer better protection than that afforded by currently available BCG vaccines. Furthermore, combined vaccination schedules against TB seem to be a promising strategy in the new millennium.

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Section: Introductionmentioning

confidence: 99%