The essential functions of coenzyme Q

Crane, F.L.; Sun, I. L.; Sun, E. E.

doi:10.1007/bf00226841

Cited by 93 publications

(73 citation statements)

References 8 publications

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“…Since coenzyme Q10 acts as an antioxidant and is able to regenerate alpha-tocopherol (Crane et al, 1993;Kaikkonen et al, 2000), a positive correlation between both antioxidants can be assumed and was confirmed. There was a negative association between beta-carotene and cholesteroladjusted Q10 concentrations.…”

Section: Discussionmentioning

confidence: 67%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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Objective: Low antioxidant intake and status have been shown to be associated with an elevated risk for various diseases. Data on the status of antioxidant vitamins, selenium and coenzyme Q10 of younger female seniors are scarce. The aim of this study was to assess the status of these antioxidants, as well as influencing factors such as dietary intake, anthropometric data and educational level in female seniors (60-70 years) in Germany. Design: Dietary intake of alpha-tocopherol, beta-carotene and ascorbic acid was determined by a 3-day diet record. Serum concentrations of alpha-tocopherol, beta-carotene, ascorbic acid, selenium and coenzyme Q10 were measured. Anthropometric measures, socioeconomic and educational status were assessed. Setting: In total, 178 elderly women without severe diseases in the region of Hannover, Germany, were included in the study. The mean (7s.d.) age and BMI of the women was 63.2 (2.73) years and 25.6 (3.77) kg/m 2 , respectively. The study participants were generally better educated than the overall German female population. Results: Dietary intake of the ascorbic acid and alpha-tocopherol was below RDA in six and 75% of the women, respectively. In comparison to estimated desirable serum concentrations of alpha-tocopherol, ascorbic acid, beta-carotene and selenium, lower concentrations were found in 23, 1, 6, and 39% of the women, respectively. Ascorbic acid (r ¼ 0.205, P ¼ 0.009) and betacarotene (r ¼ 0.173, P ¼ 0.025) intake were significantly associated with serum concentrations. Beta-carotene concentrations were influenced by the type of diet, BMI, and school education (R 2 ¼ 0.128, Po0.001). Serum selenium was positively associated with alcohol intake (r ¼ 0.229, P ¼ 0.003). Neither employment nor vocational training was predictive for the serum concentrations of antioxidant vitamins, selenium or coenzyme Q10. Conclusions: Poor status of selenium and alpha-tocopherol is highly prevalent even among younger, well-educated female seniors, whereas ascorbic acid and beta-carotene status seems sufficient in most women.

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Section: Discussionmentioning

confidence: 67%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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“…It is found in relatively higher concentrations in cells with high energy requirements, such as those of the heart, liver, muscles and pancreas. The biosynthesis of CoQ 10 from the amino acid tyrosine is a 17-step process (Figure 3) requiring at least eight vitamins (riboflavin, pyridoxine, niacinamide, ascorbic acid, cobalamin, folic acid, tocopherol, and pantothenic acid) and several trace elements (Hojerová 2000;Crane 2001). …”

Section: Biochemistry In the Human Organismmentioning

confidence: 99%

“…The electron and proton transfer functions of the quinone ring are of fundamental importance to all life forms; ubiquinone in the mitochondria of animals, plastoquinone in the chloroplasts of plants, and menaquinone in bacteria (Littarru 1994;Crane 2001).…”

Section: Biochemistry In the Human Organismmentioning

confidence: 99%

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Nourishing and health benefits of coenzyme Q<sub>10</sub>

Borekova¹,

Hojerová²,

Koprda³

et al. 2008

Czech J. Food Sci.

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“…QH 2 may function primarily as an antioxidant in these membrane regions by inhibiting lipid peroxidation or protein carboxylation (Aberg et al, 1992;Forsmark-Andree et al, 1995). Alternatively, there is evidence of participation in the plasma membrane electron transport chain, growth control, and regulation of membrane secretion (Crane et al, 1993, Sun et al, 1992.…”

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confidence: 99%

Autoxidation of Ubiquinol-6 Is Independent of Superoxide Dismutase

et al. 1996

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Ubiquinone (Q) is an essential, lipid soluble, redox component of the mitochondrial respiratory chain. Much evidence suggests that ubiquinol (QH 2 ) functions as an effective antioxidant in a number of membrane and biological systems by preventing peroxidative damage to lipids. It has been proposed that superoxide dismutase (SOD) may protect QH 2 from autoxidation by acting either directly as a superoxide-semiquinone oxidoreductase or indirectly by scavenging superoxide. In this study, such an interaction between QH 2 and SOD was tested by monitoring the fluorescence of cis-parinaric acid (cPN) incorporated phosphatidylcholine (PC) liposomes. Q 6 H 2 was found to prevent both fluorescence decay and generation of lipid peroxides (LOOH) when peroxidation was initiated by the lipid-soluble azo initiator DAMP, dimethyl 2,2′-azobis (2-methylpropionate), while Q 6 or SOD alone had no inhibitory effect. Addition of either SOD or catalase to Q 6 H 2 -containing liposomes had little effect on the rate of peroxidation even when incubated in 100% O 2 . Hence, the autoxidation of QH 2 is a competing reaction that reduces the effectiveness of QH 2 as an antioxidant and was not slowed by either SOD or catalase. The in ViVo interaction of SOD and QH 2 was also tested by employing yeast mutant strains harboring deletions in either CuZnSOD and/or MnSOD. The sod mutant yeast strains contained the same percent Q 6 H 2 per cell as wild-type cells. These results indicate that the autoxidation of QH 2 is independent of SOD.

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The essential functions of coenzyme Q

Cited by 93 publications

References 8 publications

Selenium and antioxidant vitamin status of elderly German women

Selenium and antioxidant vitamin status of elderly German women

Nourishing and health benefits of coenzyme Q<sub>10</sub>

Autoxidation of Ubiquinol-6 Is Independent of Superoxide Dismutase

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