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Cited by 261 publications
(241 citation statements)
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“…Biomarkers have been evaluated for several applications in patients with sepsis including diagnosis of infection, prognostication and therapeutic guidance. Sepsis is a common and severe condition [1,2], responsible for high mortality and morbidity rates and also for reduced quality of life [1][2][3][4]. Sepsis biomarkers may provide information beyond what is available using other metrics, and could therefore help inform clinical decision making and potentially improve patient management.…”
Section: Introductionmentioning
confidence: 99%
“…Biomarkers have been evaluated for several applications in patients with sepsis including diagnosis of infection, prognostication and therapeutic guidance. Sepsis is a common and severe condition [1,2], responsible for high mortality and morbidity rates and also for reduced quality of life [1][2][3][4]. Sepsis biomarkers may provide information beyond what is available using other metrics, and could therefore help inform clinical decision making and potentially improve patient management.…”
Section: Introductionmentioning
confidence: 99%
“…In the USA, the average mortality rate is 40% during hospitalization . In Brazil, 55% of hospitalized patients die, while the north and northeast regions have the highest mortality rates (70% and 58.3%, respectively) . Handling of severe sepsis and septic shock in ICUs represents a daunting problem, with high mortality rates …”
Section: Introductionmentioning
confidence: 99%
“…3 In Brazil, 55% of hospitalized patients die, while the north and northeast regions have the highest mortality rates (70% and 58.3%, respectively). 4 Handling of severe sepsis and septic shock in ICUs represents a daunting problem, with high mortality rates. 5 Sepsis hyperinflammation develops from the activation of the immune response by gram-negative (lipopolysaccharide) and gram-positive cell-wall endotoxins (peptidoglycans, lipoteichoic acid), which are responsible for the so-called 'damage-associated molecular patterns' (DAMPs).…”
Section: Introductionmentioning
confidence: 99%
“…2 Em 2016, a Society of Critical Care Medicine (SCCM) e a European Society of Intensive Care Medicine (ESICM) publicaram novas definições baseadas em uma análise de bancos de dados, basicamente americanos, que gerou uma mudança conceitual e a sepse passou a ser definida pela presença de disfunção orgânica secundária a resposta desregulada e exacerbada do hospedeiro frente à infecção. 3 Essa síndrome clínica caracteriza pela presença de mecanismos inflamatórios, em que ocorrem alterações celulares e circulatórias como a vasodilatação e o aumento da permeabilidade capilar, colaborando para a hipovolemia e a hipotensão, redução da densidade capilar, coagulação intravascular disseminada, o que incorre para a redução da oferta de oxigênio tecidual, acarretando o aumento do metabolismo anaeróbio e a hiperlactatemia.…”
Section: Introductionunclassified