The epidemiology of hyperferritinaemia

Abstract

Alcohol related liver disease, haemat-ological disease, renal failure and neoplasia are much more common causes of marked hyperferritinaemia than haemochromatosis. The role of weight loss in hyperferritinaemia may warrant further investigation.

Effect of HFE gene polymorphism on sustained virological response in patients with chronic hepatitis C and elevated serum ferritin

“…The reason for including only patients with serum ferritin levels above 500 ng/dL was to select genotypes 2 and 3 patients with really difficult to treat disease. Since transferring saturation was not available for all patients, serum ferritin level above 500 ng/dL was also the best available marker for iron overload, despite the fact that, in this situation, less than 10% of patients are expected to have a genetic iron overload disorder (20) . Individuals with treatment compliance outside the 80/80/80 rule were excluded to avoid introducing confounding factors such as dose reduction or treatment interruption, which could bias any potential relationship between SVR and HFE gene polymorphisms.…”

How to Follow up on Unexplained Hyperferritinemia in Primary Care

“…Alcohol related liver disease, hematological disease, renal failure, neoplastic, infection or inflammation and metabolic syndrome), whereas only 10% of cases. Hyperferritinemia cases are due to iron overload (Hemochromatosis (HH)) [3][4][5].…”

Serum ferritin levels in human immunodeficiency virus infected children and its relation with severe immunodeficiency

“…1 However, despite physiological regulation of iron homeostasis, the proportionality does not always hold true and a host of conditions have been implicated to cause markedly elevated serum ferritin levels. [2][3][4] Interpretation of an elevated serum ferritin value will vary significantly depending on the patient population and local epidemiology. 2,3 It can be abnormally elevated in a wide range of disease states including malignancy, infection, inflammation, and chronic iron-overload syndromes.…”

“…[2][3][4] Interpretation of an elevated serum ferritin value will vary significantly depending on the patient population and local epidemiology. 2,3 It can be abnormally elevated in a wide range of disease states including malignancy, infection, inflammation, and chronic iron-overload syndromes. Previous investigators have examined the underlying causes of markedly elevated ferritin levels.…”