The epidemiology of hepatitis delta infection in Italy

Sagnelli, E.; Stroffolini, Tommaso; Ascione, Antonio; Bonino, Ferruccio; Chiaramonte, M.; Colombo, Massimo; Crax, A.; Giusti, G.; Manghisi, O. G.; Pastore, Giuseppe; Piccinino, F; Rizzetto, Mario; Stazi, Maria Antonietta; Toti, M; Verme, G

doi:10.1016/0168-8278(92)90038-q

Cited by 64 publications

(43 citation statements)

References 19 publications

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“…To analyse the data according to the geographical area of residence, we considered the borderline between the north and south of the country as latitude 41n3m north, as in our previous investigation on the epidemiology of HDV infection in Italy [15]. In compliance with this division, the 322 patients from the liver units in Padua, Chieti and Sassari were considered as resident in northern Italy and the 508 patients from the units in Naples and Messina as resident in southern Italy.…”

Section: Resultsmentioning

confidence: 99%

Antibodies to hepatitis A virus in Italian patients with chronic liver disease

et al. 2001

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SUMMARYTo improve our knowledge for future hepatitis A virus (HAV) vaccination strategies we carried out a multicentre study on naturally acquired immunological protection against HAV in patients with chronic hepatitis in Italy. We enrolled 830 consecutive patients with chronic hepatitis on their first observation at one of the six Italian liver units participating in the study. Six hundred and fifty-eight patients (79n3 %) were positive for total anti-HAV and 172 (20n7%) were negative. The anti-HAV negative patients were younger (median age 33, range 11-78) than the anti-HAV positive (median age 56, 18-87). There was a higher prevalence of cases with circulating anti-HAV among the 508 patients residing in southern Italy than in the 322 residing in northern Italy (88n8% s. 64%, P 0n001). No significant difference in the anti-HAV prevalence was observed between patients from northern Italy and those from southern Italy aged 0-30 years or in those over 60 years, while in those 31-60 years old there was a higher prevalence of anti-HAV positive patients from southern Italy (90n2% s. 65n8%, P 0n0001). Of the patients with liver cirrhosis in this study, only 3 of the 26 (11n5 %) from northern Italy and 8 of the 228 (3n5 %) from southern Italy had no immunological protection against HAV infection. The data suggest that the number of patients with chronic liver disease without naturally acquired immunity against HAV is substantial in Italy, particularly in the north of the country, and that new vaccination strategies are needed.

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Section: Resultsmentioning

confidence: 99%

Antibodies to hepatitis A virus in Italian patients with chronic liver disease

et al. 2001

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“…For several years, HDV infection has been characterized by a higher prevalence in Southern than in Northern Italian areas [8][9][10][11]. However, since the survey of 2006 [12], the prevalence has become higher in the latter ones.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the present findings have been compared with the corresponding figures from the previous studies [8][9][10][11][12] to detect changes, if any.…”

Section: Introductionmentioning

confidence: 95%

“…Similarly, the prevalence of antibodies to delta virus (anti-HDV) evaluated among cohorts of chronic HBsAg carriers referring Italian hospitals progressively declined over time, being 23.4% in 1987 [8] In this paper, we report the results of a further national survey performed in 2014 on the epidemiology of chronic HDV infection in Italy. Moreover, the present findings have been compared with the corresponding figures from the previous studies [8][9][10][11][12] to detect changes, if any.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis delta infection in Italian patients: towards the end of the story?

et al. 2016

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a sex ratio (M/F) of 2.05. The majority (80.3%) of them was 50 years or older, while the proportion of subjects younger than 30 years of age was as low as 3.3%. No difference was detected by geographical area of residence. The presence of liver cirrhosis was diagnosed in 52.4% of cases. In comparison to previous studies, a further shift towards the oldest age groups and an increasing proportion of subjects having liver cirrhosis among all anti-delta-positive subjects are observed. Conclusions Currently, hepatitis delta infection mostly affects old people who have an advanced but indolent liver disease, reflecting a survival effect. The defective hepatitis delta virus is near to disappear in the country, where it has been discovered in the second half of 70s.

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“…In most reports, the local HDV prevalence is restricted to patients with chronic hepatitis B or cirrhosis, not including asymptomatic HBsAg carriers, or to special populations, as intravenous drug addicts, homosexuals, and prostitutes [8][9][10][12][13][14][15]. Therefore reports have not been representative of the whole population of HBsAg carriers in terms of HDV infection [16].…”

Section: Introductionmentioning

confidence: 99%