The EORTC treatment of early stages of hodgkin's disease: The role of radiotherapy

Tubiana, M; Henry-Amar, Michel; Hayat, M.; Burgers, M; Qasim, Malik M.; Somers, R.; Sizoo, W; Schueren, Emmanuel van der

doi:10.1016/0360-3016(84)90004-x

Cited by 80 publications

(13 citation statements)

References 14 publications

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“…1,2 External-beam radiotherapy (RT) is also very effective as a form of treatment, and combined-modality therapy is often used in early-stage disease. [3][4][5] The role of radiation is less clear in patients with disseminated lymphoma where the whole extent of the disease cannot easily be encompassed in the treatment field.…”

Section: Introductionmentioning

confidence: 99%

Consolidation Radiotherapy in Patients With Advanced Hodgkin's Lymphoma: Survival Data From the UKLG LY09 Randomized Controlled Trial (ISRCTN97144519)

Johnson

Sydes

Hancock

et al. 2010

JCO

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Section: Introductionmentioning

confidence: 99%

Consolidation Radiotherapy in Patients With Advanced Hodgkin's Lymphoma: Survival Data From the UKLG LY09 Randomized Controlled Trial (ISRCTN97144519)

Johnson

Sydes

Hancock

et al. 2010

JCO

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“…The majority of patients were treated with radiotherapy alone mostly with a mantle field that did not include an upper para-aortic node or splenic bed extension. A number of studies in adult patients have clearly shown that this is associated with a higher relapse rate [24,32]. In addition, of the 17 deaths in this category, 6 did not die of Hodgkin's lymphoma.…”

Section: Discussionmentioning

confidence: 98%

Long Term Outcome in Adolescents with Hodgkin's Lymphoma: Poor Results using Regimens Designed for Adults

Yung

Smith

Hancock

et al. 2004

Leukemia & Lymphoma

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It is unclear whether the outcome in adolescents with Hodgkin's lymphoma is as good as that in children and there are no prospective randomized trials comparing regimes used in children and adults in this setting. We have therefore performed an analysis of 210 adolescent patients diagnosed with Hodgkin's lymphoma between 1970-1997 and registered on the database held by the British National Lymphoma Investigation. Patients were treated according to adult regimens current at the time of their diagnosis. The complete response rate recorded in 209 patients was 76%. This was highly dependent on disease stage being 95% in patients with localized disease but 63% in those with advanced disease. The 5 year event free survival for the whole cohort was 50% falling to 41% at 20 years with overall survival of 81% falling to 68% at 5 and 20 years respectively. There is no significant difference in the 3 decades pertaining to this analysis. Of the 62 deaths in this cohort, 70% were due to Hodgkin's lymphoma but of the 13 deaths occurring beyond 10 years, only 3 were due to Hodgkin's lymphoma, the reminder being attributable to the late effects of therapy. Results from paediatric groups have been much more encouraging than those presented from this cohort. It seems the use of risk-adjusted combined modality therapy with minimization of radiation fields and doses and reduction of anthracycline and alkylator exposure has been successful in children and should be used in adolescents.

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“…The cumulative effect of the two modalities on the malignant tissues can be assessed by comparing the incidence of local recurrence in the irradiated lymphnode areas in patients treated by RT alone or by combination of CT + RT within the three EORTC clinical trials on early-stage Hodgkin's disease (Tubiana et al 1984) . In each of these three trials the relapse rate was approximately halved in patients treated by CT + RT, from approximately 8 per cent in patients treated by RT alone to 4 per cent .…”

Section: Contribution Of Ct and Rt To The Control Of The Primary Tumentioning

confidence: 99%

The Combination of Radiotherapy and Chemotherapy: A Review

Tubiana

1989

International Journal of Radiation Biology

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The association of radiotherapy (RT) and chemotherapy (CT) is clearly beneficial in tumours which are both chemosensitive and radiosensitive (Tubiana et al. 1987). However, contrary to the expectations, in most solid tumours this association did not lead to significant progress in long-term survival. In head and neck cancers, for example, despite a large number of controlled clinical trials, there is not yet a clear-cut demonstration of any increase in survival (DeVita et al. 1986, Tannock and Browman 1986, Taylor 1987, Tubiana et al. 1985). These disappointing results are probably due to two factors: (1) the insufficient effectiveness of the available drugs on most solid tumours; (2) the cumulative toxic effects of radiation and drugs on the normal tissues, which limits the dose of both modalities in combined treatments.

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The EORTC treatment of early stages of hodgkin's disease: The role of radiotherapy

Cited by 80 publications

References 14 publications

Consolidation Radiotherapy in Patients With Advanced Hodgkin's Lymphoma: Survival Data From the UKLG LY09 Randomized Controlled Trial (ISRCTN97144519)

Consolidation Radiotherapy in Patients With Advanced Hodgkin's Lymphoma: Survival Data From the UKLG LY09 Randomized Controlled Trial (ISRCTN97144519)

Long Term Outcome in Adolescents with Hodgkin's Lymphoma: Poor Results using Regimens Designed for Adults

The Combination of Radiotherapy and Chemotherapy: A Review

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