The Enigma of Lymphocytic Vasculitis

LeBoit, Philip E.

doi:10.1001/archderm.144.9.1215

Cited by 9 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the intriguing aspects of the disease is its long-term benign progression without any ulcerations, cutaneous infarction, scars or white atrophy despite the presence in half of the reported cases of total vascular occlusion [15] or even fibrinocruoric thrombosis (as observed in our case 2). Histopathological findings support that by injuring endothelial cells, lymphocytes are the cause and not the consequence of the fibrin deposits in the vessel walls [16]. Antiphospholipid and antinuclear antibodies are found positive in 30% of reported cases [1,2,3,8,13].…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

Macular Lymphocytic Arteritis: Three Cases Questioning Its Classification as Primary Lymphocytic Vasculitis

et al. 2013

View full text Add to dashboard Cite

Background: Macular arteritis, macular lymphocytic arteritis (MLA) or lymphocytic thrombophilic arteritis all correspond to an identical new clinicopathological entity. Its individualization as a primary cutaneous lymphocytic arteritis is still controversial for certain authors as it could represent a latent form of cutaneous polyarteritis nodosa. Materials and Methods: We report here 3 additional cases of MLA, present a review of the literature and discuss the disease's nosology. Results: MLA is characterized clinically by a benign skin eruption consisting in bilateral asymptomatic erythematous/hyperpigmented macules mainly located on the lower legs and histologically by a medium-sized cutaneous lymphocytic prominent arteritis present in early cutaneous lesions. Conclusion: These findings support that MLA may be considered as a chronic and indolent primary lymphocytic cutaneous arteritis. Nevertheless, in some cases the objective obliteration of cutaneous vessels underlines the need for continuous monitoring in MLA patients.

show abstract

Section: Discussionmentioning

confidence: 71%

“…Such an increase in autoantibodies can be temporary and can occur nonspecifically in a variety of diseases or is detected in some healthy patients [2]. The benign progression of MLA helps differentiating it from other types of vasculitis [16,17,18,19]. C-PAN remains the main differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Macular Lymphocytic Arteritis: Three Cases Questioning Its Classification as Primary Lymphocytic Vasculitis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…LV is a histopathologic finding in various and very heterogeneous dermatoses, such as connective tissue diseases, infections, lichenoid diseases, and drug reactions. However, LV is not well accepted by dermatopathologists as a pathologic mechanism because many inflammatory skin diseases present perivascular infiltrates of lymphocytes and to apply the term LV to all these conditions would make it meaningless 15 . Some authors state that LV can be defined as "a lymphocyte generally infiltrate perivascular space and located both superficial and deep, accompanied by fibrin in the wall or thrombi within the lumen of the venules."…”

Section: Discussionmentioning

confidence: 99%

Acute lichenoid and varioliform pityriasis in a pediatric patient

Marín-Hernández¹,

Escobar-García²,

Contreras³

et al. 2023

BMHIM

View full text Add to dashboard Cite

Background: Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare dermatosis recognized as a benign condition of unknown etiopathogenesis. It is more common in pediatric patients and young adults and is characterized by multiple small or large erythematous plaques spread over the trunk and extremities. Case report: We describe the case of a 5-year-old male, previously healthy, with multiple erythematous lesions that disappeared leaving hypopigmented macules. The biopsy reported histological changes suggestive of mycosis fungoides. After a second revision of lamellae in this hospital, lymphocytic vasculitis (LV) with focal epidermal necrosis consistent with acute pityriasis lichenoides (PL) was identified. Conclusions: The existing knowledge about PLEVA lacks a consensus in specifying its classification, etiopathogenesis, diagnosis, and treatment, so this clinical condition represents a medical challenge. The diagnosis is made by clinical suspicion and confirmed by histology. The objective of this article was to report a case of PLEVA with an atypical presentation due to its histopathological findings, being the first report showing LV in children, as well as a review of the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Lymphocytic vasculitis (LV) is usually arbitrarily defined by different authors as to have lymphocytes attacking a small vessel, endothelial swelling with or without fibrin deposition [ 1 ]. Infections have associated with or been attributed to the presence of vasculitis in a variable proportion of patients [ 1 ]. Many different viruses have been implicated including hepatitis B and C, as well as several bacterial infections including streptococcal infections, other causes of subacute bacterial endocarditis, meningococcal infection and tuberculosis (associated with some cases of nodular vasculitis) [ 2 ].…”

Section: Discussionmentioning

confidence: 99%