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Cited by 86 publications
(131 citation statements)
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“…Rabbit anti-mouse Ccl-2 antibody was from Acris Antibodies (Herford, Germany). Recombinant ectodomain of murine flTF was produced and characterized as described (24).…”
Section: Reagents and Antibodiesmentioning
confidence: 99%
“…Rabbit anti-mouse Ccl-2 antibody was from Acris Antibodies (Herford, Germany). Recombinant ectodomain of murine flTF was produced and characterized as described (24).…”
Section: Reagents and Antibodiesmentioning
confidence: 99%
“…4,5,9,13 Instead, it involves the inhibition of a recently described inflammatory signaling process that is mediated by the EPCR-dependent activation of PAR2 by the ternary TF-fVIIa-fXa blood coagulation initiation complex and that augments in innate immune cells a specific component of the inflammatory gene expression response to stimulation with LPS or endogenously released danger signals such as histones. 27 Because EPCR-dependent PAR2 activation by the ternary TF complex involves direct interactions of fVIIa and/or fXa Gla-domain(s) with EPCR, 37,38 and because the L8V-aPC variant with defective EPCR interaction lacks inhibitory activity, we hypothesize that inhibition of TF signaling by aPC involves the displacement of fVIIa or fXa from EPCR by aPC, resulting in the uncoupling of inflammatory PAR2 signaling. Surprisingly, this anti-inflammatory effect of signaling-selective 5A-aPC required pS and fV, 2 nonenzymatic cofactors typically associated with aPC's anticoagulant activity.…”
Section: Discussionmentioning
confidence: 99%
“…NapC2 blocks TF-fVIIa-fXa procoagulant activity but stabilizes a conformation of the TF-fVIIa-fXa complex that is conducive to PAR2 activation. 37,38 NapC2 abolished the ability of aPC to inhibit Peli1 induction by either LPS alone, or by the combination of LPS, SLIGRL, and the fXa-active-site inhibitor Nap5 39 ( Figure 4D). The fV-dependent suppression of LPS-induced gene expression by aPC, therefore, did not involve cleavage of histones, cleavage of PAR2 at R38, or the inhibition of TF procoagulant activity.…”
Section: Fv Mediates Inhibition Of Inflammatory Tf Signaling By Apcmentioning
confidence: 99%
“…Thus, MMP-9 may be the effector molecule of TF. A study on TF signaling pathways revealed that a TF-FVII complexes directly or indirectly pass through the downstream product and activate PAR-2 (Hjortoe et al, 2004;Wilson et al, 2004;Disse et al, 2011).…”
Section: Discussionmentioning
confidence: 99%