The Endocrinology of Aging and the Brain

Self-Reported Loss of Consciousness After Head Trauma Does Not Predispose to Hypopituitarism in an Older Population

“…There could have been a selection bias as the group of responders was younger and had less chronic diseases. 21 Despite the limitations described earlier, we think that it is safe to conclude that a self-reported history of HT with loss of consciousness does not seem to significantly increase the risk of hypopituitarism and lower BMD in an aging population. The main limitations of this study are lack of information about severity of head trauma and of the indication for medication use.…”

Self-Reported Loss of Consciousness After Head Trauma Does Not Predispose to Hypopituitarism in an Older Population

“…There could have been a selection bias as the group of responders was younger and had less chronic diseases. 21 Despite the limitations described earlier, we think that it is safe to conclude that a self-reported history of HT with loss of consciousness does not seem to significantly increase the risk of hypopituitarism and lower BMD in an aging population. The main limitations of this study are lack of information about severity of head trauma and of the indication for medication use.…”

Perceived Stress and Frailty in Older Adults

“…The homeostatic function of the endocrine system such as the hypothalamic-pituitary axis is reduced during aging. 24 ) Thus, the pattern of cortisol secretion, an essential biomarker of stress, may be altered. Specifically, lower morning and higher evening salivary cortisol levels are associated with frailty.…”

Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population

“…Accordingly, the virtuous cycle of IR and sarcopenia may subsequently result in impaired body energy regulation and performance, and increase the frailty incidence. Other studies 20,21 had also highlighted that three major circulating hormones were decreased in ageing body, including insulin-like growth factor-1(IGF-1), sex hormone, dehydroepiandrosterone and dehydroepiandrosterone sulfate production. IGH-1 can improve insulin sensitivity mediated through skeletal muscle and the deficiency of the IGF-1 actions cause to insulin resistance 22,23 .…”

Self-Reported Loss of Consciousness After Head Trauma Does Not Predispose to Hypopituitarism in an Older Population

“…There could have been a selection bias as the group of responders was younger and had less chronic diseases. 21 Despite the limitations described earlier, we think that it is safe to conclude that a self-reported history of HT with loss of consciousness does not seem to significantly increase the risk of hypopituitarism and lower BMD in an aging population. The main limitations of this study are lack of information about severity of head trauma and of the indication for medication use.…”

Perceived Stress and Frailty in Older Adults

“…The homeostatic function of the endocrine system such as the hypothalamic-pituitary axis is reduced during aging. 24 ) Thus, the pattern of cortisol secretion, an essential biomarker of stress, may be altered. Specifically, lower morning and higher evening salivary cortisol levels are associated with frailty.…”

Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population

“…Accordingly, the virtuous cycle of IR and sarcopenia may subsequently result in impaired body energy regulation and performance, and increase the frailty incidence. Other studies 20,21 had also highlighted that three major circulating hormones were decreased in ageing body, including insulin-like growth factor-1(IGF-1), sex hormone, dehydroepiandrosterone and dehydroepiandrosterone sulfate production. IGH-1 can improve insulin sensitivity mediated through skeletal muscle and the deficiency of the IGF-1 actions cause to insulin resistance 22,23 .…”

Self-Reported Loss of Consciousness After Head Trauma Does Not Predispose to Hypopituitarism in an Older Population

“…There could have been a selection bias as the group of responders was younger and had less chronic diseases. 21 Despite the limitations described earlier, we think that it is safe to conclude that a self-reported history of HT with loss of consciousness does not seem to significantly increase the risk of hypopituitarism and lower BMD in an aging population. The main limitations of this study are lack of information about severity of head trauma and of the indication for medication use.…”

Perceived Stress and Frailty in Older Adults

“…The homeostatic function of the endocrine system such as the hypothalamic-pituitary axis is reduced during aging. 24 ) Thus, the pattern of cortisol secretion, an essential biomarker of stress, may be altered. Specifically, lower morning and higher evening salivary cortisol levels are associated with frailty.…”

Association between HOMA-IR and Frailty among U.S. Middle-aged and Elderly Population

“…Accordingly, the virtuous cycle of IR and sarcopenia may subsequently result in impaired body energy regulation and performance, and increase the frailty incidence. Other studies 20,21 had also highlighted that three major circulating hormones were decreased in ageing body, including insulin-like growth factor-1(IGF-1), sex hormone, dehydroepiandrosterone and dehydroepiandrosterone sulfate production. IGH-1 can improve insulin sensitivity mediated through skeletal muscle and the deficiency of the IGF-1 actions cause to insulin resistance 22,23 .…”