J. Robert Lane, Margot W. Beukers, Thea Mulder-Krieger, Ad P. IJzerman
Abstract:Ad P. Ijzerman. The endocannabinoid 2arachidonylglycerol is a negative allosteric modulator of the human A adenosine receptor.
AbstractStudies of endogenous cannabinoid agonists, such as 2-arachidonylglycerol (2-AG), have revealed their potential to exert modulatory actions on other receptor systems in addition to their ability to activate cannabinoid receptors. This study investigated the effect of cannabinoid ligands on the human adenosine A 3 (hA 3 R) receptor. The endocannabinoid 2-AG was able to inhibit a…
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