The electrochemiluminescence of luminol on titania nanotubes functionalised indium tin oxide glass for flow injection analysis

Zhao, Qun; Xiao, Changbin; Tu, Yifeng

doi:10.1016/j.talanta.2015.05.026

Cited by 14 publications

(9 citation statements)

References 48 publications

(54 reference statements)

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“…Zhao and coworkers recently developed titania nanotubes (TiNTs)−functionalized indium tin oxide (ITO) coated glass for flow injection analysis (FIA) to intensify the electrochemiluminescence (ECL) of luminol for sensitive detection of ROS and antioxidants [ 58 ]. Under optimal conditions, a linear concentration range of 0.1–30 mg L −1 and a detection limit of 1.65 × 10 −10 g for resveratrol was obtained by using ECL of luminol on functionalized ITO in FIA mode.…”

Section: Design Strategies and Accomplishments For Colorimetric Sementioning

confidence: 99%

Novel Spectroscopic and Electrochemical Sensors and Nanoprobes for the Characterization of Food and Biological Antioxidants

Apak

Çekiç

Üzer

et al. 2018

Sensors

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Since an unbalanced excess of reactive oxygen/nitrogen species (ROS/RNS) causes various diseases, determination of antioxidants that can counter oxidative stress is important in food and biological analyses. Optical/electrochemical nanosensors have attracted attention in antioxidant activity (AOA) assessment because of their increased sensitivity and selectivity. Optical sensors offer advantages such as low cost, flexibility, remote control, speed, miniaturization and on-site/in situ analysis. Electrochemical sensors using noble metal nanoparticles on modified electrodes better catalyze bioelectrochemical reactions. We summarize the design principles of colorimetric sensors and nanoprobes for food antioxidants (including electron-transfer based and ROS/RNS scavenging assays) and important milestones contributed by our laboratory. We present novel sensors and nanoprobes together with their mechanisms and analytical performances. Our colorimetric sensors for AOA measurement made use of cupric-neocuproine and ferric-phenanthroline complexes immobilized on a Nafion membrane. We recently designed an optical oxidant/antioxidant sensor using N,N-dimethyl-p-phenylene diamine (DMPD) as probe, from which ROS produced colored DMPD-quinone cationic radicals electrostatically retained on a Nafion membrane. The attenuation of initial color by antioxidants enabled indirect AOA estimation. The surface plasmon resonance absorption of silver nanoparticles as a result of enlargement of citrate-reduced seed particles by antioxidant addition enabled a linear response of AOA. We determined biothiols with Ellman reagent−derivatized gold nanoparticles.

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Section: Design Strategies and Accomplishments For Colorimetric Sementioning

confidence: 99%

Novel Spectroscopic and Electrochemical Sensors and Nanoprobes for the Characterization of Food and Biological Antioxidants

Apak

Çekiç

Üzer

et al. 2018

Sensors

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“…Also a reagentless ECL electrode has been designed with luminol‐aniline co‐polymer as luminophore on nano‐TiO 2 functionalized ITO by means of cyclic voltammetry for utilizing as sensing matrix . Hollowed titania nanoshells, which were synthesized by a SiO 2 sacrificial template method, titania nanotubes, and Au decorated nano‐titania, have also been applied to enhance the ECL of luminol. Thereafter the nano‐titania supported AuAg alloy NCs had been immobilized onto ITO working electrode, the intensification of AuAg and PtAg alloy NCs on the ECL of luminol has been also investigated .…”

Section: Ecl Biosensor With Luminol As the Sensing Probementioning

confidence: 99%

“…Also a reagentless ECL electrode has been designed with luminol-aniline co-polymer as luminophore on nano-TiO 2 functionalized ITO by means of cyclic voltammetry for utilizing as sensing matrix. [57] Hollowed titania nanoshells, which were synthesized by a SiO 2 sacrificial template method, [77] titania nanotubes, [78] and Au decorated nano-titania, [76,79] have also Scheme 1. The co-polymerization of luminol with aniline.…”

Section: Intensification Of Luminol's Ecl By Using Metal/metal Oxide mentioning

confidence: 99%

Progress of the Electrochemiluminescence Biosensing Strategy for Clinical Diagnosis with Luminol as the Sensing Probe

Chen

Yan

et al. 2017

ChemElectroChem

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Electrochemiluminescence (electrogenerated chemiluminescence, ECL), which involves light emission from excited states of electrochemically generated species at the electrode surface, is widely applied for chemical analysis. Integrating the advantages of outstanding selectivity from biological recognition and the high sensitivity of ECL signaling, ECL biosensors are powerful for ultrasensitive bio‐checkups and quantification, in which luminol is adopted as an important luminophore. Nanomaterials have been introduced into ECL biosensors, which enlarge the applicable pH range and improve analytical performances, with successful applications in clinical events. In particular, this Minireview will focus on new progresses related to luminol‐based biosensors and their applications in clinical diagnosis, with emphasis on nanomaterials being employed as the improver.

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“…Additionally, TiO 2 can accelerate electron transfer. Subsequently, aqueous hydrogen peroxide and dissolved oxygen can be electrochemically reduced by TiO 2 nanoparticles, generating superoxide radicals (O 2 •– ) and hydroxyl radicals (·OH). , Once the voltage has changed the oxidative potential of the luminol, aqueous luminol can be oxidized into luminol intermediates at the ITO and TiO 2 surfaces, which react with radicals to emit luminescence (λ ∼ 420 nm). Furthermore, TiO 2 nanoparticles can absorb luminescence, which results in the separation of electrons and holes. − The surface-trapped holes can then oxidize hydrogen peroxide to produce superoxide radicals, which produce more luminescence. , Eventually, luminescence produced by the nanoparticles is sufficiently strong to distinguish these nanoparticles from the surrounding ITO surface.…”

mentioning

confidence: 99%

“…Subsequently, aqueous hydrogen peroxide and dissolved oxygen can be electrochemically reduced by TiO 2 nanoparticles, generating superoxide radicals (O 2 •– ) and hydroxyl radicals (·OH). , Once the voltage has changed the oxidative potential of the luminol, aqueous luminol can be oxidized into luminol intermediates at the ITO and TiO 2 surfaces, which react with radicals to emit luminescence (λ ∼ 420 nm). Furthermore, TiO 2 nanoparticles can absorb luminescence, which results in the separation of electrons and holes. − The surface-trapped holes can then oxidize hydrogen peroxide to produce superoxide radicals, which produce more luminescence. , Eventually, luminescence produced by the nanoparticles is sufficiently strong to distinguish these nanoparticles from the surrounding ITO surface. Compared with easily passivated novel metal surfaces, oxygen vacancies in TiO 2 crystals are not easily passivated under regular voltage, which allows the surface conditions needed for ECL generation to be maintained. , Therefore, the use of steady-state bright ECL of semiconductive TiO 2 nanoparticles for the analysis of local hydrogen peroxide efflux from single living cells is a reasonable proposal.…”

mentioning

confidence: 99%

Steady-State Electrochemiluminescence at Single Semiconductive Titanium Dioxide Nanoparticles for Local Sensing of Single Cells

et al. 2018

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Obtaining steady-state bright electrochemiluminescence (ECL) at single nanoparticles is crucial but challenging for the realization of the single-nanoparticle electrochemical sensing of single cells. In this work, steady-state bright ECL is implemented at single semiconductive titanium dioxide (TiO2) nanoparticles for sensing the local efflux from single living cells. Oxygen vacancies on the surface of rutile TiO2 nanoparticles have a high affinity for hydrogen peroxides that are not easily passivated upon exposure to voltage. Therefore, the steady-state adsorption of hydrogen peroxide by the TiO2 nanoparticle surface permits the continuous electrochemical generation of superoxide and hydroxyl radicals by electrons and surface-trapped holes at the nanoparticles, resulting in constant ECL under physiological conditions. This steady-state luminescence during continuous imaging is correlated with the concentration of hydrogen peroxide, leading to the local ECL visualization of hydrogen peroxide efflux from single cells. The successful local ECL imaging demonstrated herein provides an unprecedented approach to enable subcellular electroanalysis using single nanoparticles.

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The electrochemiluminescence of luminol on titania nanotubes functionalised indium tin oxide glass for flow injection analysis

Cited by 14 publications

References 48 publications

Novel Spectroscopic and Electrochemical Sensors and Nanoprobes for the Characterization of Food and Biological Antioxidants

Novel Spectroscopic and Electrochemical Sensors and Nanoprobes for the Characterization of Food and Biological Antioxidants

Progress of the Electrochemiluminescence Biosensing Strategy for Clinical Diagnosis with Luminol as the Sensing Probe

Steady-State Electrochemiluminescence at Single Semiconductive Titanium Dioxide Nanoparticles for Local Sensing of Single Cells

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