The Electro-oculogram in Diffuse (Familial) Drusen

Peripheral Retinal Function in Age-Related Macular Degeneration

“…The Arden ratio is believed to reflect the status of the pigment epithelial-retinal complex.27 The norms for ganzfeld testing of the EOG have been established for a background luminance of 188 cd/sq m as 1.80 or greater for patients younger than 50 years, and 1.70 or greater for older patients. 28 All eyes of all patients in our study (Table 2) had normal Arden ratios. Figure 3 plots the EOG Arden ratio for the worse vs better eyes of the 11 patients with visual acuity of 20/80 or less in one eye.…”

Peripheral Retinal Function in Age-Related Macular Degeneration

“…The Arden ratio is believed to reflect the status of the pigment epithelial-retinal complex.27 The norms for ganzfeld testing of the EOG have been established for a background luminance of 188 cd/sq m as 1.80 or greater for patients younger than 50 years, and 1.70 or greater for older patients. 28 All eyes of all patients in our study (Table 2) had normal Arden ratios. Figure 3 plots the EOG Arden ratio for the worse vs better eyes of the 11 patients with visual acuity of 20/80 or less in one eye.…”

Symptomatic abnormalities of dark adaptation in patients with EFEMP1 retinal dystrophy (Malattia Leventinese/Doyne honeycomb retinal dystrophy)

“…The small drusen seen in our patients are thin, uniform in size, and radially aligned to the fovea whereas so 49,[55][56][57] Genetic testing of patients with cuticular or basal laminar drusen for the EFEMP1 mutation should help to determine the relationship between this disorder and ML/DHRD. There are conflicting reports regarding the functional attributes of various dominantly-inherited drusen syndromes with respect to the ERG and EOG, [4][5][6]8,15,41,46,47,56,[58][59][60][61][62][63] colour vision, 4,8,11,44,58,64 and dark adaptation. 4,6,8,41,44,46,58,63,65 This disparity in findings may be related to several factors that include the definition of inherited vs age-related drusen, 61,62 the sensitivity of the tests employed, the stage of the disease, or whether they represent the same or different disorders.…”

Inherited Macular Dystrophies and Differential Diagnostics

“…The findings on full-field ERG are typically normal or subnormal, and there are no any criteria to differentiate between inherited and noninherited drusen (32). The findings on EOG are also usually normal (33). A decrease of mfERG macular amplitude associated with macular dysfunction is recorded, and the abnormalities found are similar both in the presence of macular degeneration, and dominant drusen.…”

Peripheral Retinal Function in Age-Related Macular Degeneration

“…The Arden ratio is believed to reflect the status of the pigment epithelial-retinal complex.27 The norms for ganzfeld testing of the EOG have been established for a background luminance of 188 cd/sq m as 1.80 or greater for patients younger than 50 years, and 1.70 or greater for older patients. 28 All eyes of all patients in our study (Table 2) had normal Arden ratios. Figure 3 plots the EOG Arden ratio for the worse vs better eyes of the 11 patients with visual acuity of 20/80 or less in one eye.…”

Symptomatic abnormalities of dark adaptation in patients with EFEMP1 retinal dystrophy (Malattia Leventinese/Doyne honeycomb retinal dystrophy)

“…The small drusen seen in our patients are thin, uniform in size, and radially aligned to the fovea whereas so 49,[55][56][57] Genetic testing of patients with cuticular or basal laminar drusen for the EFEMP1 mutation should help to determine the relationship between this disorder and ML/DHRD. There are conflicting reports regarding the functional attributes of various dominantly-inherited drusen syndromes with respect to the ERG and EOG, [4][5][6]8,15,41,46,47,56,[58][59][60][61][62][63] colour vision, 4,8,11,44,58,64 and dark adaptation. 4,6,8,41,44,46,58,63,65 This disparity in findings may be related to several factors that include the definition of inherited vs age-related drusen, 61,62 the sensitivity of the tests employed, the stage of the disease, or whether they represent the same or different disorders.…”

Inherited Macular Dystrophies and Differential Diagnostics

“…The findings on full-field ERG are typically normal or subnormal, and there are no any criteria to differentiate between inherited and noninherited drusen (32). The findings on EOG are also usually normal (33). A decrease of mfERG macular amplitude associated with macular dysfunction is recorded, and the abnormalities found are similar both in the presence of macular degeneration, and dominant drusen.…”

Peripheral Retinal Function in Age-Related Macular Degeneration

“…The Arden ratio is believed to reflect the status of the pigment epithelial-retinal complex.27 The norms for ganzfeld testing of the EOG have been established for a background luminance of 188 cd/sq m as 1.80 or greater for patients younger than 50 years, and 1.70 or greater for older patients. 28 All eyes of all patients in our study (Table 2) had normal Arden ratios. Figure 3 plots the EOG Arden ratio for the worse vs better eyes of the 11 patients with visual acuity of 20/80 or less in one eye.…”

Symptomatic abnormalities of dark adaptation in patients with EFEMP1 retinal dystrophy (Malattia Leventinese/Doyne honeycomb retinal dystrophy)

“…The small drusen seen in our patients are thin, uniform in size, and radially aligned to the fovea whereas so 49,[55][56][57] Genetic testing of patients with cuticular or basal laminar drusen for the EFEMP1 mutation should help to determine the relationship between this disorder and ML/DHRD. There are conflicting reports regarding the functional attributes of various dominantly-inherited drusen syndromes with respect to the ERG and EOG, [4][5][6]8,15,41,46,47,56,[58][59][60][61][62][63] colour vision, 4,8,11,44,58,64 and dark adaptation. 4,6,8,41,44,46,58,63,65 This disparity in findings may be related to several factors that include the definition of inherited vs age-related drusen, 61,62 the sensitivity of the tests employed, the stage of the disease, or whether they represent the same or different disorders.…”

Inherited Macular Dystrophies and Differential Diagnostics

“…The findings on full-field ERG are typically normal or subnormal, and there are no any criteria to differentiate between inherited and noninherited drusen (32). The findings on EOG are also usually normal (33). A decrease of mfERG macular amplitude associated with macular dysfunction is recorded, and the abnormalities found are similar both in the presence of macular degeneration, and dominant drusen.…”