The Elastic Tissue of Bruch's Membrane

Progression of Peripapillary and Macular Chorioretinal Atrophy in Multifocal Choroiditis Is Associated With Periatrophic Inflammatory Plumes

“…Bruch membrane may become permeated with lipid, 15 lipid breakdown products, 16,17 calcium, 18 and iron. 19 In aging, Bruch membrane becomes thicker, 20 has accumulation of electron-dense beaded material on elastic fibrils, 21 and breakdown of the elastic fibers. 22 There are lipid and protein modifications to Bruch membrane over time.…”

Progression of Peripapillary and Macular Chorioretinal Atrophy in Multifocal Choroiditis Is Associated With Periatrophic Inflammatory Plumes

“…Bruch membrane may become permeated with lipid, 15 lipid breakdown products, 16,17 calcium, 18 and iron. 19 In aging, Bruch membrane becomes thicker, 20 has accumulation of electron-dense beaded material on elastic fibrils, 21 and breakdown of the elastic fibers. 22 There are lipid and protein modifications to Bruch membrane over time.…”

Asian age-related macular degeneration: from basic science research perspective

“…Bruch's membrane is lamellar extracellular material (ECM) composed of five layers, i.e., inner basal lamina of RPE, outer collagenous zone, elastic zone, inner collagenous zone, and outer basal lamina of choriocapillaris. Bruch's membrane inner border is well demarcated, whereas the outer limit is ill-defined with expansions of Bruch's membrane in the choroid forming intercapillary pillars [22]. Progressive age-related changes that characterize early AMD includes thickening of Bruch's membrane, accumulation of extracellular deposits such as basal laminar deposit and membranous debris.…”

Progression of Peripapillary and Macular Chorioretinal Atrophy in Multifocal Choroiditis Is Associated With Periatrophic Inflammatory Plumes

“…Bruch membrane may become permeated with lipid, 15 lipid breakdown products, 16,17 calcium, 18 and iron. 19 In aging, Bruch membrane becomes thicker, 20 has accumulation of electron-dense beaded material on elastic fibrils, 21 and breakdown of the elastic fibers. 22 There are lipid and protein modifications to Bruch membrane over time.…”

Asian age-related macular degeneration: from basic science research perspective

“…Bruch's membrane is lamellar extracellular material (ECM) composed of five layers, i.e., inner basal lamina of RPE, outer collagenous zone, elastic zone, inner collagenous zone, and outer basal lamina of choriocapillaris. Bruch's membrane inner border is well demarcated, whereas the outer limit is ill-defined with expansions of Bruch's membrane in the choroid forming intercapillary pillars [22]. Progressive age-related changes that characterize early AMD includes thickening of Bruch's membrane, accumulation of extracellular deposits such as basal laminar deposit and membranous debris.…”

Progression of Peripapillary and Macular Chorioretinal Atrophy in Multifocal Choroiditis Is Associated With Periatrophic Inflammatory Plumes

“…Bruch membrane may become permeated with lipid, 15 lipid breakdown products, 16,17 calcium, 18 and iron. 19 In aging, Bruch membrane becomes thicker, 20 has accumulation of electron-dense beaded material on elastic fibrils, 21 and breakdown of the elastic fibers. 22 There are lipid and protein modifications to Bruch membrane over time.…”

Asian age-related macular degeneration: from basic science research perspective

“…Bruch's membrane is lamellar extracellular material (ECM) composed of five layers, i.e., inner basal lamina of RPE, outer collagenous zone, elastic zone, inner collagenous zone, and outer basal lamina of choriocapillaris. Bruch's membrane inner border is well demarcated, whereas the outer limit is ill-defined with expansions of Bruch's membrane in the choroid forming intercapillary pillars [22]. Progressive age-related changes that characterize early AMD includes thickening of Bruch's membrane, accumulation of extracellular deposits such as basal laminar deposit and membranous debris.…”