The efficiency and stability of bubble formation by acoustic vaporization of submicron perfluorocarbon droplets

Reznik, Nikita; Shpak, Oleksandr; Gelderblom, Erik; Williams, Ronald J.; Jong, Nico de; Versluis, Michel; Burns, Peter N.

doi:10.1016/j.ultras.2013.04.005

Cited by 88 publications

(69 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The acoustic pressure amplitudes required to nucleate the droplet have been observed to be very high. In a typical ADV experiment, before impinging on the droplet the ultrasound wave from a focused transducer travels a distance on the order of a few centimeters (7,(17)(18)(19)(22)(23)(24). Under these conditions the wave that arrives at the focus of the transducer can be highly distorted owing to nonlinear propagation (25,26).…”

Section: Significancementioning

confidence: 99%

Acoustic droplet vaporization is initiated by superharmonic focusing

Shpak

Verweij

Vos

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

169

148

View full text Add to dashboard Cite

Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor imaging. The physical mechanisms underlying the acoustic activation of these phase-change emulsions into a bubbly dispersion, termed acoustic droplet vaporization, have not been well understood. The droplets have a very high activation threshold; its frequency dependence does not comply with homogeneous nucleation theory and localized nucleation spots have been observed. Here we show that acoustic droplet vaporization is initiated by a combination of two phenomena: highly nonlinear distortion of the acoustic wave before it hits the droplet and focusing of the distorted wave by the droplet itself. At high excitation pressures, nonlinear distortion causes significant superharmonics with wavelengths of the order of the droplet size. These superharmonics strongly contribute to the focusing effect; therefore, the proposed mechanism also explains the observed pressure thresholding effect. Our interpretation is validated with experimental data captured with an ultrahigh-speed camera on the positions of the nucleation spots, where we find excellent agreement with the theoretical prediction. Moreover, the presented mechanism explains the hitherto counterintuitive dependence of the nucleation threshold on the ultrasound frequency. The physical insight allows for the optimization of acoustic droplet vaporization for therapeutic applications, in particular with respect to the acoustic pressures required for activation, thereby minimizing the negative bioeffects associated with the use of high-intensity ultrasound.

show abstract

Section: Significancementioning

confidence: 99%

Acoustic droplet vaporization is initiated by superharmonic focusing

Shpak

Verweij

Vos

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

169

148

View full text Add to dashboard Cite

show abstract

“…But the noncondensable gas does not contract as a result leaving an extremely small gas bubble that will contribute to form a larger bubble on the next acoustic cycle. This process has been observed [56] and helps to manifest that the size of gas bubbles after cessation of ultrasound irradiation is much bigger than the size expected in the initial PFC droplets [57,58].…”

Section: Bubble Growthmentioning

confidence: 55%

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

View full text Add to dashboard Cite

Recently, the advances in perfluorocarbon nanoparticles have been introduced to expand the diagnostic and therapeutic capability of ultrasound molecular imaging, a non-invasive diagnostic imaging, which passed from robust anatomical presentation to detection of physiological processes and recognition of specific tissue epitopes at the cellular level. The good properties of perfluorocarbon nanoparticles, such as nontoxicity, small size, phase-shift capability, etc., have been resulted in tremendous potential prospects in clinical application. Herein, this review focuses on the mechanisms of perfluorocarbon nanoparticles in terms of phase transition and ultrasonic theranostic. And the potential applications of perfluorocarbon nanoparticles in ultrasound medicine are also discussed.

show abstract

“…8.4A and B. At prologue time scales, in the order of microseconds, vaporizing droplets can merge and fragment 202 . Both the merging and the fragmentation of vaporizing monodisperse droplets have a remarkable degree of symmetry.…”

Section: Vaporization Dynamics Of Monodipserse Dropletsmentioning

confidence: 99%

Monodisperse bubbles and droplets for medical applications

Segers¹

View full text Add to dashboard Cite

The efficiency and stability of bubble formation by acoustic vaporization of submicron perfluorocarbon droplets

Cited by 88 publications

References 43 publications

Acoustic droplet vaporization is initiated by superharmonic focusing

Acoustic droplet vaporization is initiated by superharmonic focusing

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Monodisperse bubbles and droplets for medical applications

Contact Info

Product

Resources

About