The Efficacy of Low‐Level Laser Therapy for Shoulder Tendinopathy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Haslerud, Sturla; Magnussen, Liv Heide; Joensen, Jón; Lopes-Martins, Rodrigo Álvaro Brandão; Bjordal, Jan Magnus

doi:10.1002/pri.1606

Cited by 72 publications

(65 citation statements)

References 53 publications

(116 reference statements)

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“…A promising treatment in wound healing is the low-level light therapy (LLLT), a system using low-power light to stimulate cellular function and biological activity. 7 Recent studies showed the importance of LLLT in pain, 8,9 skin, 7,10 and wound 11,12 care. In recent years, investigators have examined the effect of LLLT on the DFU treatment, 13 finding improvement in pain scores [14][15][16] or in clinical foot sensation.…”

Section: Introductionmentioning

confidence: 99%

Effect of low-level light therapy on diabetic foot ulcers: a near-infrared spectroscopy study

et al. 2017

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Diabetic foot ulcer (DFU) is a diabetic complication due to peripheral vasculopathy and neuropathy. A promising technology for wound healing in DFU is low-level light therapy (LLLT). Despite several studies showing positive effects of LLLT on DFU, LLLT’s physiological effects have not yet been studied. The objective of this study was to investigate vascular and nervous systems modification in DFU after LLLT. Two samples of 45 DFU patients and 11 healthy controls (HCs) were recruited. The total hemoglobin (totHb) concentration change was monitored before and after LLLT by near-infrared spectroscopy and analyzed in time and frequency domains. The spectral power of the totHb changes in the very-low frequency (VLF, 20 to 60 mHz) and low frequency (LF, 60 to 140 mHz) bandwidths was calculated. Data analysis revealed a mean increase of totHb concentration after LLLT in DFU patients, but not in HC. VLF/LF ratio decreased significantly after the LLLT period in DFU patients (indicating an increased activity of the autonomic nervous system), but not in HC. Eventually, different treatment intensities in LLLT therapy showed a different response in DFU. Overall, our results demonstrate that LLLT improves blood flow and autonomic nervous system regulation in DFU and the importance of light intensity in therapeutic protocols.

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Section: Introductionmentioning

confidence: 99%

Effect of low-level light therapy on diabetic foot ulcers: a near-infrared spectroscopy study

et al. 2017

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“…This was the first systematic review of the effects of LLLT on pain and functional outcomes in patients with shoulder tendinopathy. Previous reviews have assessed the effects of LLLT therapy on different tendinopathies, or have included studies that addressed the use of both low and high power laser therapy 26 . This review was conducted in accordance with PRISMA 14 recommendations, ensuring consistency and uniformity in systematic review reporting.…”

Section: Discussionmentioning

confidence: 99%

Efeito do laser de baixa intensidade na dor e na funcionalidade de pacientes com tendinopatia de ombro: uma revisão sistemática

Leotty¹,

Lima²,

Araújo³

2020

Fisioter. Pesqui.

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RESUMO Dentre as diferentes intervenções fisioterapêuticas existentes, a terapia com laser de baixa intensidade (LBI) é altamente utilizada em distúrbios musculoesqueléticos. Evidências sugerem que o LBI é eficaz na modulação de mediadores inflamatórios, contribuindo para o reparo tecidual e sendo, portanto, indicado para o tratamento de condições inflamatórias em geral. Contudo, resultados heterogêneos foram relatados sobre sua eficácia em tendinopatias de ombro. Assim, o objetivo deste estudo foi revisar sistematicamente ensaios clínicos randomizados sobre os efeitos do LBI na dor e na funcionalidade de pacientes com tendinopatia de ombro. Dois revisores realizaram independentemente buscas nas bases de dados PubMed, SciELO, Cochrane e PEDro. Foram incluídos ensaios clínicos randomizados, com seres humanos diagnosticados com tendinopatia de ombro e submetidos ao LBI, com desfechos de dor e/ou funcionalidade. A avaliação do risco de viés de cada estudo foi realizada por meio da escala PEDro. Oito estudos (73%) foram considerados com menor risco de viés, e três (27%) foram considerados com alto risco de viés. Onze estudos, totalizando 486 participantes, foram incluídos nesta revisão. O LBI reduz de forma estatisticamente significativa a dor em 45% dos estudos, e apenas um estudo apresentou aumento estatisticamente significativo na funcionalidade. Futuras revisões sistemáticas sobre o efeito combinado de LBI e exercícios, assim como sobre o efeito da terapia de LBI com dosagens recomendadas no tratamento de tendinopatias de ombro, são ainda necessárias.

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“…Their effect is based on mechano-thermal phenomena which in some way affect the nociceptive afferent nerve fibers [19,20], changing their activity and suppressing neurostimulators resulting from the pain receptors of peripheral nerves [21]. The analgesic effect of LLLT however, has been supported by systematic reviews of both medical [22,23] and dental fields [24].…”

Section: Action Mechanism Of Llltmentioning

confidence: 99%

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

Karoussis¹,

Kyriakidou²,

Psarros³

et al. 2018

Dentistry

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Lasers nowadays have several applications in many research fields. In the life sciences and especially in Periodontology, Low Level Laser Therapy (LLLT) has proven to be particularly interesting. Low intensity radiation in specific wavelengths has been known to trigger cellular proliferation and differentiation, through molecular mechanisms that are still not fully elucidated. These effects might be triggered by mitochondria and through Reactive Oxygen Species (ROS). These in turn, can activate other molecular pathways and signaling cascade, resulting in the activation of a plethora of transcriptional factors. In this review we aim to highlight the mechanism of action and the effects of LLLT. We also aim to highlight how different wavelengths and energy applied can have a distinct impact on the effectiveness of LLLT. Finally, we provide insight on its current and potential future applications.

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The Efficacy of Low‐Level Laser Therapy for Shoulder Tendinopathy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Cited by 72 publications

References 53 publications

Effect of low-level light therapy on diabetic foot ulcers: a near-infrared spectroscopy study

Effect of low-level light therapy on diabetic foot ulcers: a near-infrared spectroscopy study

Efeito do laser de baixa intensidade na dor e na funcionalidade de pacientes com tendinopatia de ombro: uma revisão sistemática

Effects and Action Mechanism of Low Level Laser Therapy (LLLT): Applications in Periodontology

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