The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study

Tunca, Mehmet; Tankurt, Ethem; Akpınar, Hale; Akar, Servet; Hizli, Nail; Gonen, Ofer

doi:10.1093/rheumatology/36.9.1005

Cited by 63 publications

(24 citation statements)

References 13 publications

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“…In colchicine-resistant patients, IFNα was reported to shorten the episode duration in addition to control the episodes (89). Nevertheless, in a double-blind controlled study performed by the same investigators, no beneficial effect of IFNα could be demonstrated (90).…”

Section: Treatmentmentioning

confidence: 99%

Familial Mediterranean Fever

Küçük

Gezer²,

Uçar

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on short arm of Chromosome 16. The disease is diagnosed based on clinical evaluation. Amyloidosis is the most important complication. The only agent that decreases the development of amyloidosis and the frequency and severity of the episodes is colchicine, which has been used for about 40 years. In this review, we aimed to discuss especially the most recent advances about Familial Mediterranean Fever which is commonly seen in our population.

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Section: Treatmentmentioning

confidence: 99%

Familial Mediterranean Fever

Küçük

Gezer²,

Uçar

et al. 2014

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Interferon can clear pre-core promoter HBV infection and cure PAN. Considering the effectiveness of interferon on FMF and PAN; we preferred to give this agent in addition to conventional therapies with methylprednisolone and cyclophosphamide (8)(9)(10)(11)(12)(13). Likewise, our patient responded well to the addition of the interferon therapy.…”

Section: Discussionmentioning

confidence: 95%

“…Recent reports suggest that interferon could be effective to control the symptoms in FMF patients which were resistant to colchicines (8,9). Patients with hepatitis-related vasculitis including PAN respond to interferon therapy.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Interferon-alpha in a Patient with Resistant Familial Mediterranean Fever Complicated by Polyarteritis Nodosa

et al. 2004

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Familial Mediterranean fever (FMF) is a recurrent self-limiting polyserositis. Polyarteritis nodosa (PAN) complicating FMF is very rare. Here, we present a 17-year-old male patient with FMF who subsequently developed PAN 2 weeks after hepatitis A infection. This case was also complicated with perirenal haematoma, and right nephrectomy was performed. The clinical condition of the patient was improved after therapy with intravenous and oral corticosteroid and intravenous cyclophosphamide. However, the FMF attacks and vasculitic skin lesions again occurred while he was using colchicine plus immunosuppressive agents a few months later. Interferon-alpha therapy was administered and the attacks were resolved within 3 months. He has not experienced any other symptom during the follow-up period of 28 months. (Internal Medicine 43: 612-614, 2004)

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“…We suggest that BMT should be considered, albeit as a last resort, in patients who are extremely unresponsive to all therapies including colchicine and interferon ␣. 34 …”

Section: Discussionmentioning

confidence: 99%

Allogeneic bone marrow transplantation: cure for familial Mediterranean fever

Milledge

Shaw

Mansour

et al. 2002

Blood

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We describe data on a 7-year-old girl with congenital dyserythropoietic anemia (CDA), who also had familial Mediterranean fever (FMF). Repeated transfusions required since the age of 6 months to treat her CDA led to iron overload and a persistently high ferritin level. Her relapsing FMF made effective iron chelation therapy very difficult. Consequently, at the age of 4 years, she underwent allogeneic, sibling bone marrow transplantation (BMT). During conditioning for her BMT, symptoms of FMF, including splenomegaly, arthritis, and recurrent abdominal pain, began to resolve and she was gradually weaned off colchicine. Now, 2 years after the transplantation, she remains free from FMF symptomatology and is off all immunosuppressants. This case demonstrates that symptoms of FMF can be alleviated by the therapy used during allogeneic BMT. In this patient it is likely that the missing factor in FMF is now being provided by granulocytes derived from the stem cells within transplanted bone marrow. (Blood. 2002;100: 774-777)

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The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study

Cited by 63 publications

References 13 publications

Familial Mediterranean Fever

Familial Mediterranean Fever

The Efficacy of Interferon-alpha in a Patient with Resistant Familial Mediterranean Fever Complicated by Polyarteritis Nodosa

Allogeneic bone marrow transplantation: cure for familial Mediterranean fever

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