The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications

Ostrowski, Robert P.; Stępień, Katarzyna; Pucko, Emanuela; Matyja, Ewa

doi:10.5114/aoms.2017.65081

Cited by 16 publications

(6 citation statements)

References 68 publications

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“…The ECHM document is from 2016. In the meantime, many papers [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ] have been published in favour of HBOT, so that its level of evidence may have been increased.…”

Section: Discussionmentioning

confidence: 99%

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series

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Santarella

et al. 2020

IJERPH

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Topics: Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). Introduction: Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used fMRI technique for this purpose, till now. Methods: All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms). Results: After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas. Conclusions: These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT.

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Section: Discussionmentioning

confidence: 99%

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series

Cevolani

Donato

Santarella

et al. 2020

IJERPH

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“…Among the various signaling and growth molecules, HIF-1 alpha was stabilized by HBOT, inhibiting activation of hypoxia [ 147 ], slowing down prolyl hydroxylase-induced degradation [ 148 ], and enhanced signaling of Wnt/beta-catenin pathways that raised levels of active neural stem cells [ 149 ]. High levels of ROS during NSCs proliferation may also induce their own renewal, suggesting drug inhibition of ROS may downregulate ROS reproductive activity [ 150 ] and enhancement of pro-NSC signaling pathways to promote NSC survival.…”

Section: Hbot-primed Stem Cells As a Promising Therapymentioning

confidence: 99%

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

et al. 2020

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Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.

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“…NIX, induced by HIF‐1α under hypoxia, has been found to act in concert with p75 to mediate neuronal apoptosis after experimental intracerebral hemorrhage (Shen et al, ). As HIF‐1α has been found to play a role in hemorrhagic and traumatic brain injuries, and can be modulated by high oxygen concentrations, the use of various hyperbaric oxygen modalities has been postulated for patients with TBI and cerebral hemorrhage (Ostrowski, Stepien, Pucko, & Matyja, ).…”

Section: Involvement Of Hif In Cell Deathmentioning

confidence: 99%

The insights into molecular pathways of hypoxia‐inducible factor in the brain

Ostrowski

Zhang

2018

J of Neuroscience Research

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The objectives of this present work were to review recent developments on the role of hypoxia‐inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. In addition, HIF‐1α and HIF‐2α actions may vary in the same tissues. The multiple roles of HIF in stem cells are emerging. HIF not only regulates expression of target genes and thereby influences resultant protein levels but also contributes to epigenetic changes that may reciprocally provide feedback regulations loops. These HIF‐dependent alterations in neurological diseases and its responses to treatments in vivo need to be examined alongside with a functional status of subjects involved in such studies. The knowledge of HIF pathways might be helpful in devising HIF‐mimetics and modulating drugs, acting on the molecular level to improve clinical outcomes, as exemplified here by clinical and experimental data of selected brain diseases, occasionally corroborated by the data from disorders of other organs. Because of complex role of HIF in brain injuries, prospective therapeutic interventions need to differentially target HIF responses depending on their roles in the molecular mechanisms of neurologic diseases.

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The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications

Cited by 16 publications

References 68 publications

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

The insights into molecular pathways of hypoxia‐inducible factor in the brain

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