The efficacy of albumin–globulin ratio to predict prognosis in cancer patients

Roberts, Will S.; Delladio, William; Price, Shawn; Murawski, Alec; Nguyen, Hoang

doi:10.1007/s10147-023-02380-4

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…Multiple studies have shown that malnutrition is very prevalent in NSCLC patients and pervasive across disease and treatment trajectories ( 13 , 14 ). Several recent findings have shown that prognostic nutritional index (PNI) ( 15 ), albumin (ALB) ( 16 ), and albumin-to-globulin ratio (AGR) score ( 17 ) are as closely related to the prognosis of NSCLC as they are to numerous other solid tumors. Therefore, this study proposed to construct a novel prognostic indicator, PNAGR, according to the integration of inflammatory markers and nutritional scores, clinical significance was evaluated in NSCLC patients, yielding valuable research evidence was provided for the NSCLC management in the prediction and decision-making personal aspects.…”

Section: Introductionmentioning

confidence: 99%

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

Li,

Liu,

2024

Transl Cancer Res

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Background Lung cancer is one of the most common contributors to cancer-related deaths worldwide. This study aimed to develop a new blood index on the basis of the patient’s systemic inflammation and nutritional status, which can be used to predict the prognosis of patients with non-small cell lung cancer (NSCLC). Methods Pre-treatment blood markers were analyzed in 556 NSCLC patients from 2010 to 2019. A least absolute shrinkage and selection operator (LASSO) method was used to select indicators to establish a new integrated biomarker (PNAGR). Kaplan-Meier survival curves were used to assess the prognostic impact of platelet-to-lymphocyte ratio (PLR), albumin (ALB), and the PNAGR. The prognostic value was verified using univariate and multivariate Cox analyses. Results We used four biomarkers including PLR, ALB, 1/albumin-to-globulin ratio (1/AGR), and neutrophil/albumin-to-globulin ratio (N/AGR) were used to screen for the PNAGR using LASSO. Patients with high PNAGR demonstrated lower overall survival (OS) compared to those with low PNAGR. In both univariate and multivariate analyses, PNAGR was revealed as an independent prognostic factor for OS. The predictive power of PNAGR [area under the curve (AUC): 0.753] was higher than that of the metrics alone. Conclusions PNAGR is a novel and effective clinical prognostic tool with good clinical predictive value for NSCLC patients.

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Section: Introductionmentioning

confidence: 99%

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

Li,

Liu,

2024

Transl Cancer Res

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Preoperative blood-based nutritional biomarkers as significant prognostic factors after intravesical BCG therapy in patients with non-muscle-invasive bladder cancer

Ye,

Tang,

et al. 2024

World J Urol

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Clinical role of pretreatment albumin-to-alkaline phosphatase ratio in lung cancer: a meta-analysis

Yang,

Wang,

et al. 2024

Sci Rep

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The association between pretreatment albumin-to-alkaline phosphatase ratio (AAPR) and clinicopathological parameters and prognosis in lung cancer is unclear. The study aimed to identify the clinical role of pretreatment AAPR among lung cancer patients. Several databases were searched for relevant studies. The primary outcome and secondary outcome were long-term survival including the overall survival (OS) and progression-free survival (PFS) and clinicopathological characteristics, respectively. The hazard ratios (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were combined. A total of 11 publications involving 10,589 participants were included in this meta-analysis. The pooled results manifested that a lower pretreatment AAPR predicted poorer OS (HR = 0.65, 95% CI 0.59–0.71, P < 0.001) and PFS (HR = 0.68, 95% CI 0.59–0.78, P < 0.001). Furthermore, subgroup analysis for the OS and PFS based on the pathological type and treatment showed similar results and pretreatment AAPR was significantly associated with worse prognosis. Besides, pretreatment AAPR was significantly associated with male (RR = 1.08, 95% CI 1.03–1.13, P < 0.001), poor differentiation (RR = 1.33, 95% CI 1.03–1.73, P = 0.029), advanced T stage (RR = 1.25, 95% CI 1.03–1.52, P = 0.026), N stage (RR = 1.34, 95% CI 1.15–1.55, P < 0.001) and TNM stage (RR = 1.14, 95% CI 1.06–1.223, P < 0.001). Therefore, pretreatment AAPR is significantly related to prognosis and tumor stage in lung cancer and patients with a lower pretreatment AAPR are more likely to experience poor survival and advanced tumor stage.

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The efficacy of albumin–globulin ratio to predict prognosis in cancer patients

Cited by 4 publications

References 62 publications

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

Preoperative blood-based nutritional biomarkers as significant prognostic factors after intravesical BCG therapy in patients with non-muscle-invasive bladder cancer

Clinical role of pretreatment albumin-to-alkaline phosphatase ratio in lung cancer: a meta-analysis

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