The efficacy of absorbable polysaccharide haemostats in wound healing

Abstract

Wound healing represents an ancient problem for humans, and various materials and methods have been tried for wound dressing. A dressing should protect against infection and shorten healing; moreover, it should not cause tissue damage and should be nonallergenic, cost effective and easy to apply. These are characteristics that may be found in herbal extracts. An absorbable polysaccharide haemostat (APH) is a plant-based haemostatic agent. We aimed to evaluate the effect of APH on wound healing. A total of 24 Wistar rats were divided into three groups, each consisting of eight rats. We generated triangular tissue defects on the dorsal regions of the rats. The wound size of each rat was drawn on acetate paper on the 3rd, 7th and 14th days and dressed with APH, saline and wheat meal. Wound healing rates were calculated using planimetric software. Scar tissue excision was performed on the 14th day and histopathological examination was carried out. The mean wound contraction rate was statistically higher in the APH group than in the wheat meal and saline groups on the 14th day (P < 0.05). There was no significant difference in polymorphonuclear leukocytes intensity between the saline and APH groups when stained with haematoxylin and eosin (P > 0.05). However, the intensities of fibroblasts (P < 0.01), vascular proliferation (P = 0.01) and inflammatory score (P = 0.02) were significantly different in the saline and APH groups. APH has favourable effect on wound healing. In addition to its blood-stopping effect, APH may be useful for tissue defects, which arise after trauma or surgical procedures.

Management of pericatheter dialysate leaks using hemostatic agents

“…In their study examining the effect of polysaccharide hemostatic agents on wound healing in a rat model, Sonmez et al found that the collagen type I/III ratio, inflammatory score, fibroblast density, and vascular proliferation were significantly higher in the polysaccharide hemostatic agent group than in the saline group. Wound contraction rates were also significantly higher in the polysaccharide hemostatic agent group than in the control group 15 …”

“…Prolonged bleeding and excessive exudation can delay wound healing. Polysaccharide hemostatic agents provide hemostasis, absorb excessive exudation, and cover the entire wound surface 15 . In their study examining the effect of polysaccharide hemostatic agents on wound healing in a rat model, Sonmez et al found that the collagen type I/III ratio, inflammatory score, fibroblast density, and vascular proliferation were significantly higher in the polysaccharide hemostatic agent group than in the saline group.…”

“…Studies in the literature have shown the effects of polysaccharide hemostatic agents on wound healing in addition to their hemostatic effect. 15,16 Hemostasis, inflammation, proliferation and remodeling are the stages of wound healing, which are completed in about 3 to 14 days. Prolonged bleeding and excessive exudation can delay wound healing.…”

Rizophora Mangle E Ácido Tânico :Uma Associação Em Creme Para O Tratamento De Feridas

“…O creme de dexpantenol a 5% é amplamente utilizado, pois indica melhorias na cicatrização de feridas (Heise et al, 2012;Oguz et al, 2015;Ulger et al, 2014), visto que penetra facilmente na pele em concentrações locais elevadas. Os efeitos mais significativos de formulações com dexpantenol a 5% incluem a estimulação da epitelização, granulação e o alívio de prurido (Ebner et al, 2002 (Das, 2013;Diegelmann e Evans, 2004;Ebner et al, 2002;Khoshneviszadeh et al, 2014;Sonmez et al, 2015). Sugere-se que esta atividade estimuladora de fibroblastos da derme no grupo da planta estudada é devido à presença de taninos hidrolisáveis (Bueno et al, 2014).…”

“…(Melchor et al, 2001;Bandaranayake, 2002;Marrero et al, 2006;Berenguer et al, 2006;De-Faria et al, 2012 A cicatrização de feridas é um processo dinâmico, interativo e iniciado em resposta a uma injúria (Guo e Dipietro, 2010), cujo objetivo é restaurar a continuidade anatômica efuncional do tecido, sendo essencial para a manutenção da integridade do organismo (Barbul,1990;Broughton et al, 2006;Thornton et al, 1997 (Fernandez et al 2002, Perera et al 2010. Fernandez et al (2002) (Das, 2013;Diegelmann e Evans, 2004;Ebner et al, 2002;Khoshneviszadeh et al, 2014;Sonmez et al, 2015). Sugere-se que esta atividade estimuladora de fibroblastos da derme no grupo da planta estudada é devido à presença de taninos hidrolisáveis (Bueno et al, 2014).…”