2014
DOI: 10.1186/s13054-014-0699-2
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Abstract: IntroductionSepsis and septic shock are leading causes of intensive care unit (ICU) mortality. They are characterized by excessive inflammation, upregulation of procoagulant proteins and depletion of natural anticoagulants. Plasma exchange has the potential to improve survival in sepsis by removing inflammatory cytokines and restoring deficient plasma proteins. The objective of this study is to evaluate the efficacy and safety of plasma exchange in patients with sepsis.MethodsWe searched MEDLINE, EMBASE, CENTR… Show more

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Cited by 148 publications
(126 citation statements)
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References 51 publications
(58 reference statements)
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“…These results provide prevalence and outcome associations that will help to provide information to prospective studies on benefits of PE in pediatric sepsis . Clinical studies (mostly conducted on adult patients) showed TPE treatment is effective and associated with decreased mortality in sepsis, septic shock, Disseminated intravascular coagulation, and Multiple organ dysfunction syndrome (MODS) . Recently, TPE was also reported to be beneficial in previously healthy pediatric patients with fulminant sepsis‐induced multiorgan failure, if instituted early (within hours) in disease course .…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…These results provide prevalence and outcome associations that will help to provide information to prospective studies on benefits of PE in pediatric sepsis . Clinical studies (mostly conducted on adult patients) showed TPE treatment is effective and associated with decreased mortality in sepsis, septic shock, Disseminated intravascular coagulation, and Multiple organ dysfunction syndrome (MODS) . Recently, TPE was also reported to be beneficial in previously healthy pediatric patients with fulminant sepsis‐induced multiorgan failure, if instituted early (within hours) in disease course .…”
Section: Discussionmentioning
confidence: 89%
“…14 Clinical studies (mostly conducted on adult patients) showed TPE treatment is effective and associated with decreased mortality in sepsis, septic shock, Disseminated intravascular coagulation, and Multiple organ dysfunction syndrome (MODS). 12,[15][16][17][18] Recently, TPE was also reported to be beneficial in previously healthy pediatric patients with fulminant sepsisinduced multiorgan failure, if instituted early (within hours) in disease course. 15 A recent randomized study in sepsis concluded that blood purification using hemoperfusion or TPE was associated with decreased mortality when compared to no blood purification (37.5% vs 50.1%; P < .001).…”
Section: Discussionmentioning
confidence: 99%
“…Busund and colleagues showed a tendency toward improved mortality with adjunct TPE in adult patients with sepsis and multiple organ failure in the sole, adult-only randomized controlled trial on this subject [10] while a meta-analysis by Rimmer showed mortality benefit in adult patients as well [11]. Drawing from this data, Patel and colleagues utilized TPE during the 2009 H1N1 influenza A outbreak in three pediatric patients presenting in a similar fashion to those seen with fulminant COVID-19 today [12].…”
mentioning
confidence: 99%
“…The largest adult trial to date randomized septic patients to plasmapheresis or standard therapy, with a reduction in death with plasmapheresis(58). A recent meta-analysis of published TPE trials to date(59) found a small treatment effect on mortality in adults. However, an attempt at a pediatric RCT of TPE in patients with sepsis(60) was stopped due to poor enrollment, without clear trends in improvement.…”
Section: Extracorporeal Approaches To Patient Supportmentioning
confidence: 99%