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“…In terms of bleeding sequela, one particularly interesting area of continued investigation may be in further clarifying and expanding the use of TPO memetics. Evidence suggests that preprocedural TPO is associated with fewer platelet transfusions and less bleeding 89 . However, current data are limited by significant lack of standardization in transfusion practices, paucity of data prior to high‐risk surgeries or procedures, and concern regarding potential thrombosis‐related adverse events 89 .…”
Section: Discussionmentioning
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“…In terms of bleeding sequela, one particularly interesting area of continued investigation may be in further clarifying and expanding the use of TPO memetics. Evidence suggests that preprocedural TPO is associated with fewer platelet transfusions and less bleeding 89 . However, current data are limited by significant lack of standardization in transfusion practices, paucity of data prior to high‐risk surgeries or procedures, and concern regarding potential thrombosis‐related adverse events 89 .…”
Section: Discussionmentioning
“…Evidence suggests that preprocedural TPO is associated with fewer platelet transfusions and less bleeding 89 . However, current data are limited by significant lack of standardization in transfusion practices, paucity of data prior to high‐risk surgeries or procedures, and concern regarding potential thrombosis‐related adverse events 89 . Notably, minimization of transfusion burden is also beneficial in that it mitigates sensitization prior to transplant, which complicates cross‐matching for future transfusions.…”
Section: Discussionmentioning
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“…25 In a recent systematic review, the use of TPORAs in patients with CLD undergoing planned procedures was reported to significantly increase platelet counts and decrease the incidence of platelet transfusions versus placebo. 26 In addition, TPORA therapy also decreased the incidence of total periprocedural bleeding without increasing the rate of thrombosis. In the US algorithm for thrombocytopenia in patients with CLD, TPORAs are recommended as first-line treatment for patients with CLD and severe thrombocytopenia (platelet count <50 � 10 9 /L) who are planned to undergo invasive procedures.…”
Section: Treatment Of Thrombocytopenia In Patients With Cldmentioning
“…Therefore, their role in reducing periprocedural bleeding remains uncertain 52,53 . A subsequent meta‐analysis reported a 35% relative risk reduction in periprocedural bleeding 54 . These agents may thus be useful in patients with marked thrombocytopenia (<30 000/µl) or with additional bleeding risk factors.…”
Section: Case 2: Dental Extractions and Risk Of Bleedingmentioning