The efficacy and safety of Huangqi Guizhi Wuwu decoction for rheumatoid arthritis

Abstract

Background: Rheumatoid arthritis has the characteristics of slow progression, long course, and repeated attacks. At present, western medicine commonly used in clinical practice not only reduces pain and improves symptoms, but also has more adverse reactions, affecting the health, and life of patients. In ancient China, Huangqi Guizhi Wuwu decoction was used by doctors to treat rheumatoid arthritis, with remarkable effect. In recent years, many clinical studies have also shown that Huangqi Guizhi Wuwu decoction has reliable effect in treating rheumatoid arthritis, but there is no evidence of evidence-based medicine. Therefore, this study aims to systematically evaluate the clinical efficacy and safety of Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis. Methods: Using computer to retrieve PubMed, The Cochrance Library, Embase, Web of Science, CNKI, VIP and Wanfang database, in addition manually retrieve Google academic and Baidu academic to collect all randomized controlled trials for Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis, including relevant academic journal and conference papers, dissertations, from the establishment of the database to July 2020. After 2 evaluators independently screened the literature, extracted the data, and evaluated the risk of bias included in the study, RevMan5.3 software was used to analyze the data. Results: This research evaluate the efficacy and safety of Huangqi Guizhi Wuwu decoction in treating Rheumatoid arthritis from the aspects of clinical efficacy rate, visual analog scale (VAS), swollen joint count (SJC), morning stiffness time, Rrythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and adverse reaction incidence. Conclusion: This study will provide reliable evidence for the clinical application of Huangqi Guizhi Wuwu decoction in the treatment of rheumatoid arthritis. Ethics and dissemination: The private information from individuals will not publish. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/RZY3V.

An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis

“…As a chronic and systemic autoimmune inflammatory disease ( Scott et al, 2010 ; Wasserman 2011 ; Smolen et al, 2017 ), the multiple factors contributing to RA and its complex pathogenesis bring challenges for therapeutic interventions. TCM has evident advantages in treating complex diseases, such as multi-target and multicomponent treatment ( Wang L. et al, 2020 ; Shi et al, 2020 ; Yang et al, 2021 ). EMP is comprised of PAR and ALD, which have been widely applied in the treatment of rheumatic diseases ( Resch et al, 1998 ; Kim et al, 2011 ; Xian et al, 2011 ; Tang et al, 2018 ; Wan 2018 ; Zhang et al, 2018 ; Li et al, 2020 ; Zhang et al, 2021 ).…”

“…TCM can effectively treat RA with high safety and few adverse effects ( Shi et al, 2020 ). Increasing studies about RA have paid attention to the effects of TCM on the treatment of RA, and more and more evidence confirms that a variety of TCM formulas can have effective treatment on RA ( Wang et al, 2011 ; Zhang et al, 2015 ; Guo et al, 2016 ; Cheng et al, 2017 ; Guo et al, 2017 ; Wang et al, 2018 ; Wang et al 2020a ; Wang et al 2020b ; Liu et al, 2020 ), such as Ermiao Powder (EMP) ( Li et al, 2020 ), Danggui-Sini-decoction ( Cheng et al, 2017 ; Wang L. et al, 2020 ), Huangqi-Guizhi Wuwu-Decoction ( Wang et al, 2020a ; Wang et al, 2020b ; Liu et al, 2020 ), Bi-Qi capsule ( Wang et al, 2011 ; Wang et al, 2018 ), Wu-Tou Decoction ( Zhang et al, 2015 ; Guo et al, 2017 ), and Guizhi-Shaoyao-Zhimu ( Guo et al, 2016 ). Among these formulas, EMP is widely used in clinical.…”

Gc- MS Screening and in-Silico Prediction of Pila Globosa Extract Against the Bone Diseases in Calcitonin Receptor

“…Thus, with the aid of molecular docking various molecules from natural and animal origin are being discovered for their role in drug discovery and the mechanism of action are deciphered. One such example can be seen in a study conducted by Liu et al, in 2020, where the therapeutic effect of the herbal decoction Huangqi Guizhi Wuwu Decoction, used in Chinese traditional medicine for 1000 years for treating rheumatoid arthiritis, was confirmed through molecular docking that identified the presence of certain important active compounds such as quercetin, kaempferol, and beta-sitosterol [22].…”

Effectiveness of Huangqi Guizhi Wuwu decoction combined with rehabilitation training for shoulder hand syndrome after stroke: A systematic review and meta-analysis

“…A comprehensive evaluation of the full-text articles led to the exclusion of 2 studies due to inconsistencies in intervention measures, resulting in a final sample of 13 studies. [15][16][17][18][19][20][21][22][23][24][25][26][27] Table 3 provides an overview of the characteristics of the incorporated trials, all of which were conducted in China, involving 1270 participants with SHS after stroke. The sample sizes ranged from 45 to 109 participants, and the intervention periods varied between 4 weeks to 90 days.…”