The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Akbari, Maryam; Ostadmohammadi, Vahidreza; Lankarani, Kamran Bagheri; Tabrizi, Reza; Kolahdooz, Fariba; Heydari, Seyed Taghi; Kavari, Seyed Habibollah; Mirhosseini, Naghmeh; Mafi, Alireza; Dastorani, Majid; Asemi, Zatollah

doi:10.1055/s-0044-101355

Cited by 63 publications

(31 citation statements)

References 42 publications

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“…VD was regarded as a typical vitamin regulating calcium and phosphorus homeostasis previously . Recently VD is discovered as a highly versatile molecule with emerging roles in immunity, cancer, fatty liver disease, and ALD . A large body of clinical evidence has demonstrated the prevalence and risks of VD deficiency in various chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, VD is regarded as a typical vitamin modulating bone development by regulating calcium and phosphorus homeostasis . Now, VD is discovered as a highly versatile molecule with emerging roles in numbers of diseases . VD ameliorates nonalcoholic fatty liver disease by repressing oxidative stress and inflammation in an NRF2‐dependent manner .…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop

Zhang

Xue

et al. 2019

Molecular Nutrition Food Res

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Scope Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Oxidative stress induced during the alcohol metabolism plays a crucial role in ALD, and clinical evidence demonstrates the prevalence and risks of vitamin D (VD) deficiency in ALD. This study aims to explore the mechanism of VD administration to ameliorate alcohol‐induced cell injury. Methods and results VD activates NRF2 (nuclear factor erythroid 2 (NF‐E2)‐related factor 2) signals along with upregulation of ALDH2 expression. Knockdown of NRF2 eliminates the protective effects of VD treatment. ALDH2 knockdown not only partially affects this protection, but also mildly reduces NRF2 expression. ALDH2 overexpression enhances ERK phosphorylation and upregulated NRF2 transcription via a newly identified TRE in the exon 1 of NRF2. Conclusion This study provides evidence that VD protects against alcohol‐induced cell injury within an NRF2‐ALDH2 feedback loop. NRF2 induced by VD could transcriptionally upregulate ALDH2 expression to help metabolize alcohol. TRE‐driven transcriptional upregulation of NRF2 through ALDH2‐ERK/MEK signals would further exert the anti‐oxidant effects. The study explores a novel potential protection of VD in alcohol‐induced liver cell injury, and contributes to alcohol‐related liver disease nutritional therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop

Zhang

Xue

et al. 2019

Molecular Nutrition Food Res

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“…In addition, the role of minerals like calcium and vitamin D in the development of many diseases has been evaluated, especially endocrine, inflammation, and oxidative stress, recently [95,96]. A plethora of Ca 2+ -permeable channels in T cells at various locations, with unique activation mechanisms, have been reported to be necessary for T cell activation, maturation, and secretion of cytokines [97].…”

Section: Other Immunological Mechanisms Of Pcosmentioning

confidence: 99%

“…Furthermore, vitamin D's anti-inflammatory impact on human pathophysiology is well-accepted [100]. A current meta-analysis of randomized controlled trials concluded that vitamin D supplementation to women with PCOS results in an improvement in hsCRP, malondialdehyde, and total antioxidant capacity [95,96]; serum total testosterone and androstenedione levels were reportedly lowered in vitamin D-calcium cosupplement group as compared to the control group [101], in response to upregulated insulin receptor genes [102]. However, vitamin D does not affect the symptoms of hyperandrogenism [103].…”

Section: Other Immunological Mechanisms Of Pcosmentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

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Polycystic ovary syndrome (PCOS) a long-known endocrinopathy and one of the most common endocrine-reproductivemetabolic disorders in women, which can lead to infertility. Although the precise etiology remains unclear, PCOS is considered as a complex genetic trait, with a high degree of heterogeneity. Besides, hormones and immune cells, including both innate and adaptive immune cells, are reportedly a cross talk in PCOS. Chronic low-grade inflammation increases autoimmune disease risk. This proinflammatory condition may, in turn, affect vital physiological processes that ultimately cause infertility, such as ovulation failure and embryo implantation. Here, we review the accumulating evidence linking PCOS with inflammatory status providing an overview of the underlying hormone-mediated dysregulation of immune cells. We mainly focus on the correlational evidence of associations between immune status in women and the increased prevalence of PCOS, along with the specific changes in immune responses. Further recognition and exploration of these interactions may help elucidate PCOS pathophysiology and highlight targets for its treatment and prevention.

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“…Traditionally, vitamin D (VD) was regarded as a typical vitamin modulating bone development and regulating calcium and phosphorus homeostasis . Recently, VD is discovered as a highly versatile molecule with emerging roles in immunity, cancer, infectious diseases, toxins induced‐inflammation, and fibrosis . A large body of clinical evidence has demonstrated the prevalence and risks of VD deficiency in various chronic disease and toxins induced tissue damage .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

Tao

Zhang

Xue

et al. 2019

Environmental Toxicology

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Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro. To elucidate the effects and mechanisms of VD in particles-induced pulmonary damage, a murine model was established with fine particles intratracheal instillation along with VD intramuscular injection. Our study demonstrated that treatment with VD attenuated particles-induced pulmonary damage and promoted tissue repair by repressing of TGFβ1 signaling pathway and upregulation of MMP9 expression. VD treatment could also regulate the autophagy-related signals along with activation of Nrf2 transcription factor. Furthermore, the results from the in vitro study demonstrated that VD protected against particles-induced cells' damage through the induction of autophagy in an Nrf2-dependent manner. VD treatment caused the degradation of P62 and its bound Keap1, which decreased the Nrf2 ubiquitination and increasing its protein stability. Our work explored a novel potential mechanism in the protection of VD in particlesinduced pulmonary injury and tissue repair, and could further bring insights into exploring antifine particles exposure caused inflammation among other natural products and contributes to inflammation disease medical therapies. K E Y W O R D Sautophagy, fine particulate matter, Nrf2 signals, TGFβ1, vitamin D

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The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 63 publications

References 42 publications

Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop

Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner

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