The Effects of UV Irradiation and Gas Plasma Treatment on Living Mammalian Cells and Bacteria: A Comparative Approach

Соснин, Э. А.; Stoffels, E.; Ерофеев, М. В.; Kieft, I.E.; Kunts, Sergei E.

doi:10.1109/tps.2004.833401

Cited by 131 publications

(82 citation statements)

References 18 publications

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“…We hypothesize 17 Petri dish with blood agar, seeded by ∼ 1.3 × 10 7 cfu/cm 2 (10 9 cfu/ml) of skin flora and then treated by FE-DBD plasma for 10 s. While the plasma region diameter is roughly 25 mm, the "inner" circle of inactivated bacteria and fungi diameter is ∼35 mm and the "outer" circle where the bacteria is partially inactivated (colonies are visible) is ∼54 mm Fig. 18 Schematic illustration of FE-DBD treatment of agar dishes with bacterial broth that this is due to high concentration of short-lived active species and radicals as well as UV radiation that is unable to penetrate far out of e-plasma region (especially vacuum UV with wavelengths below 180 nm) [32,33]. …”

Section: Tissue Sterilizationmentioning

confidence: 99%

Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air

Fridman

Peddinghaus

Balasubramanian

et al. 2006

Plasma Chem Plasma Process

583

337

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Thermal plasma discharges have been widely used in the past for treatment of living human and animal tissue. However, extensive thermal damage and tissue desiccation occurs due to extreme temperatures. Some solutions have been offered where the temperature is lowered by short current pulses, addition of noble gases, or significant decrease in the size of treatment electrodes. We propose a method of direct treatment of living tissue that occurs at room temperature and pressure without visible or microscopic tissue damage. The presented Floating-Electrode Dielectric Barrier Discharge plasma is proven electrically safe to human subjects and our results show no gross (visual) or histological (microscopic) damage to skin samples in minutes, complete tissue sterilization from skin flora in seconds, and blood clot formation in seconds of electric plasma treatment. We also observe significant hastening of blood clot formation via electric plasma induced catalysis of "natural" processes occurring in human blood. A model describing these processes is offered.

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Section: Tissue Sterilizationmentioning

confidence: 99%

Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air

Fridman

Peddinghaus

Balasubramanian

et al. 2006

Plasma Chem Plasma Process

583

337

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“…Another very strong disinfectant is UV radiation [44,47,48], but its role in atmospheric plasma sterilization goes from modest [2], [49]- [51] to highly effective [8,24,46,52], depending on the type and concentration of bacteria or spores, the amount and composition Figure 11. A photograph of a microtiter plate with treated cells after the CV test.…”

Section: Plasma Treatment Of E Coli and S Aureus Bacteriamentioning

confidence: 99%

The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells

et al. 2010

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“…1 In several experimental studies, Stoffels and co-workers 3,4 have shown it to be capable of locally killing cells and loosening them from their substrate for removal. This allows malignant cells to be disposed of in an orderly fashion, diminishing the risk of infections and damage to nearby benign cells: the cell membrane stayed intact and thus kept the potentially harmful content of the cell contained.…”

Section: Introductionmentioning

confidence: 99%

Numerical description of discharge characteristics of the plasma needle

Brok

Bowden

Dijk

et al. 2005

Journal of Applied Physics

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The plasma needle is a small atmospheric, nonthermal, radio-frequency discharge, generated at the tip of a needle, which can be used for localized disinfection of biological tissues. Although several experiments have characterized various qualities of the plasma needle, discharge characteristics and electrical properties are still not well known. In order to provide initial estimates on electrical properties and quantities such as particle densities, we employed a two-dimensional, time-dependent fluid model to describe the plasma needle. In this model the balance equation is solved in the drift-diffusion approach for various species and the electron energy, as well as Poisson's equation. We found that the plasma production occurs in the sheath region and results in a steady flux of reactive species outwards. Even at small ͑Ͻ0.1% ͒ admixtures of N 2 to the He background, N 2 + is the dominant ion. The electron density is typically 10 11 cm −3 and the dissipated power is in the order of 10 mW. These results are consistent with the experimental data available and can give direction to the practical development of the plasma needle.

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The Effects of UV Irradiation and Gas Plasma Treatment on Living Mammalian Cells and Bacteria: A Comparative Approach

Cited by 131 publications

References 18 publications

Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air

Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air

The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells

Numerical description of discharge characteristics of the plasma needle

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