The effects of two different antioxidant combinations on sperm parameters

Abstract

Background: Studies demonstrate that getting antioxidants in the course of treatment has a positive impact beneficial effect on fertility, especially on the quality of sperm. Because of that reason antioxidants are recommended as a potentially influential treatment for infertility in men. However, it is argued that this treatment is not based on sufficient evidence and has no effect on the rate of healthy pregnancy. Objective: In this study, two different antioxidant combinations with different doses and contents were evaluated in terms of their effect on sperm parameters. Materials/methods: A total of 122 patients diagnosed with idiopathic infertility were enrolled in our multicenter study. The patients were divided into two different groups: The first group used a combination 2 × 1 sachet form (l-carnitine 1 g, acetyl-l-carnitine 0.5 g, fructose 1 g, citric acid 0.50 mg, selenium 50 µg, coenzyme Q10 20 mg, vitamin C 90 mg, zinc 10 mg, folic acid 200 µg, and vitamin B12 1.5 µg) and the second group used a combination tablets form 2 × 1 (l-carnitine 500 mg, selenium 50 µg, coenzyme Q10 20 mg, vitamin C 60 mg, zinc 15 mg, folic acid 400 µg, vitamin E, and ginseng 15 µg) for 6 months. The total semen volume, the total sperm number, sperm concentration, sperm motility, and lastly morphological findings of the patients were compared at the end of 6 months. Results: The mean age of the patients participating in the study was 30.8 ± 6.05 years. No significant difference was found between the two groups in terms of baseline sperm count. There was a significant difference between the baseline and sixth-month values of the patients using both combinations. However, no significant statistical difference was found between the groups according to the sixth-month data. The combinations of both antioxidants had a positive effect on sperm parameters, and the use of different doses and contents had a similar effect. Conclusion: Both antioxidants respectively had a positive effect on sperm parameters and also the use of different doses and contents had a similar effect.

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

“…[40][41][42] Additionally, antioxidant treatment has been shown to have a positive effect on semen quality. 43,44 Moreover, several antioxidant or oxidant compounds were found to alleviate oxidative damage in sperm caused by FA exposure. 34,37 SOD and GSHPx are antioxidant enzymes protecting cells against oxidative damage, and MDA is a oxidation parameter measuring lipid peroxidation.…”

“…In addition, some environmental pollutants and viruses induce poor semen quality through increasing levels of oxidative stress . Additionally, antioxidant treatment has been shown to have a positive effect on semen quality . Moreover, several antioxidant or oxidant compounds were found to alleviate oxidative damage in sperm caused by FA exposure .…”

Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

“… 41 , 42 Drugs commonly used to improve energy metabolism include coenzyme Q 10 and l ‐carnitine, which are often combined with antioxidant effects. 43 …”

“…41,42 Drugs commonly used to improve energy metabolism include coenzyme Q 10 and L-carnitine, which are often combined with antioxidant effects. 43 The latest review of 61 included studies indicated that there was insufficient evidence that empiric therapy and nutritional supplements improved semen parameters; moreover, there was insufficient evidence that these methods increased live birth or pregnancy rates. 44 Increasing evidence suggests that improved microcirculation perfusion of the testis can effectively promote spermatogenesis.…”

Effect of varicocelectomy on detailed sperm morphology parameters

“…[4,5] Many studies have investigated the efficacy of varicocelectomy on improvement in semen parameters, and several authors have found a significant improvement in semen quality after this surgery. [6][7][8] Although many meta-analyses have shown that all techniques used for varicocele treatment improve sperm parameters, microsurgical varicocelectomy (MSV) is the optimal technique due to its lower rate of complications, such as hydrocele and varicocele recurrence. [9][10][11] According to a metaanalysis by Cayan et al, [12] the rate of hydroceles was significantly lower in MSV (0.44%) than in laparoscopic varicocelectomy (2.84%).…”