The effects of the genetic background on herbicide resistance fitness cost and its associated dominance in Arabidopsis thaliana

Paris, Margot; Roux, Fabrice; Berard, Aurélie; Reboud, Xavier

doi:10.1038/hdy.2008.92

Cited by 61 publications

(73 citation statements)

References 55 publications

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“…Multiple segregation crosses: Another method that enables the evaluation of the influence of the genetic background on variations in the magnitude and expression of resistance costs consists of pairing either the same resistant line (RR or resistant) with different SS (or susceptible) plants collected from different environments (locations, regions and so on) (Paris et al, 2008) or multiple RS plants for a particular resistance allele, but originated from different populations (Menchari et al, 2008). By analysing the same 2,4-D herbicide resistance mutation in eight different segregating genetic backgrounds, Paris et al (2008) report that the fitness cost of a resistance gene is variable depending on the local genetic composition.…”

Section: Methodological Approaches To Control For Genetic Backgroundmentioning

confidence: 99%

“…By analysing the same 2,4-D herbicide resistance mutation in eight different segregating genetic backgrounds, Paris et al (2008) report that the fitness cost of a resistance gene is variable depending on the local genetic composition. The study provides evidence for the existence of compensatory genes that are segregating in different genetic backgrounds (see below Compensatory evolution of resistance costs).…”

Section: Methodological Approaches To Control For Genetic Backgroundmentioning

confidence: 99%

“…Significant effects of dissimilar genetic backgrounds on the expression and magnitude of several resistance mutations have been documented (Bergelson, 1994;Menchari et al, 2008;Paris et al, 2008). Given this, we may easily speculate that pleiotropic resistance costs may be compensated by natural selection at other polymorphic loci within the genome (Maisnier-Patin and Andersson, 2004).…”

Section: Compensatory Evolution Of Resistance Costsmentioning

confidence: 98%

“…This process creates the opportunity for co-adaptation or integration of the new resistance allele into the genome (Cohan et al, 1994;Guillemaud et al, 1998). By crossing an herbicide-resistant line (axr1-3 resistance allele) to nine natural accessions, Paris et al (2008) showed a potential compensation of both the resistance cost and its associated dominance by the genetic diversity present within A. thaliana. To our knowledge, no study has been specifically designed to detect the genetic basis of resistance cost modifiers in plants.…”

Section: Compensatory Evolution Of Resistance Costsmentioning

confidence: 99%

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A unified approach to the estimation and interpretation of resistance costs in plants

2011

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International audiencePlants exhibit a number of adaptive defence traits that endow resistance to past and current abiotic and biotic stresses. It is generally accepted that these adaptations will incur a cost when plants are not challenged by the stress to which they have become adapted--the so-called 'cost of adaptation'. The need to minimise or account for allelic variation at other fitness-related loci (genetic background control) is frequently overlooked when assessing resistance costs associated with plant defence traits. We provide a synthesis of the various experimental protocols that accomplish this essential requirement. We also differentiate those methods that enable the identification of the trait-specific or mechanistic basis of costs (direct methods) from those that provide an estimate of the impact of costs by examining the evolutionary trajectories of resistance allele frequencies at the population level (indirect methods). The advantages and disadvantages for each proposed experimental design are discussed. We conclude that plant resistance systems provide an ideal model to address fundamental questions about the cost of adaptation to stress. We also propose some ways to expand the scope of future studies for further fundamental and applied insight into the significance of adaptation costs

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Section: Methodological Approaches To Control For Genetic Backgroundmentioning

confidence: 99%

Section: Methodological Approaches To Control For Genetic Backgroundmentioning

confidence: 99%

Section: Compensatory Evolution Of Resistance Costsmentioning

confidence: 98%

Section: Compensatory Evolution Of Resistance Costsmentioning

confidence: 99%

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A unified approach to the estimation and interpretation of resistance costs in plants

2011

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“…Nevertheless, the expression of transgenes depends on the genetic background (Bravo et al, 2007;Paris et al, 2008), and the physiological and environmental conditions (Lepri et al, 2002;Mahon et al, 2002;Olsen et al, 2005). The stability, inheritance and expression of transgenes in subsequent generations of breeding are of paramount importance for functional analysis as well as for crop improvement (Dietz-Pfeilstetter and Kirchner, 1998;Kathuria et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Bt δ-endotoxins in leaf tissues of tropical Bt maize populations

Murenga¹,

Danson²,

Mugo³

et al. 2012

Afr. J. Biotechnol.

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In Kenya, stem borers destroy an estimated 13.5% of farmers' annual maize harvest. Maize transformed using Bacillus thuringiensis (Bt) derived genes controls stem borers without negative effects to humans, livestock or the environment. The effectiveness and sustainability of Bt transgenic technology in the control of stem borers depends on the levels of concentration of the Bt δ-endotoxins in plant tissues. Kenya introduced Bt maize events to test the efficacy of Bt maize in controlling stem borers, and to develop high-yielding and locally adapted Bt maize germplasm for farmers. The objective of this study was to assess under greenhouse conditions the concentration levels of Bt δ-endotoxins in the leaf tissues of the parents, the F 1 , and the F 2:3 populations of tropical maize, as a measure of stability and sustainability. Kenya introduced Bt maize events to test the efficacy of Bt maize in controlling stem borers, and to develop high-yielding and locally adapted Bt maize germplasm for farmers. The objective of this study was to assess under greenhouse conditions the concentration levels of Bt δ-endotoxins in the leaf tissues of the parents, the F1, and the F2:3 populations of tropical maize, as a measure of stability and sustainability. Two public Bt maize lines (Event 216 and Event 223) containing the cry1Ab::ubi gene were crossed with two non-Bt maize inbred lines, CML144 and CML159, to assess how the concentrations of Bt δ-endotoxins are transmitted from parents to F 1 and to F 2 generations. The mean concentration of Bt δ-endotoxins (μg/g) was 4.93 and 4.63 in Events 216 and 223 respectively. As expected, F 1 generations of all the crosses had similar concentrations of Bt δ-endotoxins. However, the F 2 generations showed a spread of concentrations. These findings may imply that genotypes with a higher mean concentration of Bt δ-endotoxins also have a lower level of plant damage traits expressed. In addition, these observations indicate that the cry1Ab gene was dominant and was inherited following the Mendelian segregation and that Events 216 and 223 could be utilized as reliable sources of resistance to stem borers in maize breeding programmes.

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Modeling the evolution of herbicide resistance in weed species with a complex life cycle

Holmes

Lindquist

Rebarber

et al. 2021

Ecological Applications

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A growing number of weed species have evolved resistance to herbicides in recent years, which causes an immense financial burden to farmers. An increasingly popular method of weed control is the adoption of crops that are resistant to specific herbicides, which allows farmers to apply the herbicide during the growing season without harming the crop. If such crops are planted in the presence of closely related weed species, it is possible that resistance genes could transfer from the crop species to feral populations of the wild species via gene flow and become stably introgressed under ongoing selective pressure by the herbicide. We use a density‐dependent matrix model to evaluate the effect of planting such crops on the evolution of herbicide resistance under a range of management scenarios. Our model expands on previous simulation studies by considering weed species with a more complex life cycle (perennial, rhizomatous weed species), studying the effect of environmental variation in herbicide effectiveness, and evaluating the role of common simplifying genetic assumptions on resistance evolution. Our model predictions are qualitatively similar to previous modeling studies using species with a simpler life cycle, which is, crop rotation in combination with rotation of herbicide site of action effectively controls weed populations and slows the evolution of herbicide resistance. We find that ignoring the effect of environmental variation can lead to an over‐ or under‐prediction of the speed of resistance evolution. The effect of environmental variation in herbicide effectiveness depends on the resistance allele frequency in the weed population at the beginning of the simulation. Finally, we find that degree of dominance and ploidy level have a much larger effect on the predicted speed of resistance evolution compared to the rate of gene flow.

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The effects of the genetic background on herbicide resistance fitness cost and its associated dominance in Arabidopsis thaliana

Cited by 61 publications

References 55 publications

A unified approach to the estimation and interpretation of resistance costs in plants

A unified approach to the estimation and interpretation of resistance costs in plants

Quantification of Bt δ-endotoxins in leaf tissues of tropical Bt maize populations

Modeling the evolution of herbicide resistance in weed species with a complex life cycle

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