The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin

Castillo, Manuel H.; Perkins, Eddie; Campbell, John H.; Doerr, R.; Hassett, James M.; Kandaswami, Chithan; Middleton, Elliott

doi:10.1016/0002-9610(89)90132-3

Cited by 76 publications

(37 citation statements)

References 20 publications

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“…In the first experiment, CT26-bearing BABL/c mice and LL/2-bearing C57BL/6N mice were coded and divided into seven groups (n = 10 for each group). Treatment was initiated when tumor volume was f90 mm 3 . These mice were given i.v.…”

Section: Methodsmentioning

confidence: 99%

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Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

Yuan

Chen

Fan

et al. 2006

Clinical Cancer Research

229

164

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Purpose: Quercetin is a potent chemotherapeutic drug. Clinical trials exploring different schedules of administration of quercetin have been hampered by its extreme water insolubility. To overcome this limitation, this study is aimed to develop liposomal quercetin and investigate its distribution in vivo and antitumor efficacy in vivo and in vitro. Experimental Design: Quercetin was encapsulated in polyethylene glycol 4000 liposomes. Biodistribution of liposomal quercetin i.v. at 50 mg/kg in tumor-bearing mice was detected by high-performance liquid chromatography. Induction of apoptosis by liposomal quercetin in vitro was tested.The antitumor activity of liposomal quercetin was evaluated in the immunocompetent C57BL/6N mice bearing LL/2 Lewis lung cancer and in BALB/c mice bearing CT26 colon adenocarcinoma and H22 hepatoma. Tumor volume and survival time were observed. The mechanisms underlying the antitumor effect of quercetin in vivo was investigated by detecting the microvessel density, apoptosis, and heat shock protein 70 expression in tumor tissues. Results: Liposomal quercetin could be dissolved in i.v. injection and effectively accumulate in tumor tissues. The half-time of liposomal quercetin was 2 hours in plasma. The liposomal quercetin induced apoptosis in vitro and significantly inhibited tumor growth in vivo in a dosedependent manner. The optimal dose of liposomal quercetin resulted in a 40-day survival rate of 40%. Quantitative real-time PCR showed that liposomal quercetin down-regulated the expression of heat shock protein 70 in tumor tissues. Immunohistochemistry analysis showed that liposomal quercetin inhibited tumor angiogenesis as assessed by CD31 and induced tumor cell apoptosis. Conclusions: Our data indicated that pegylated liposomal quercetin can significantly improve the solubility and bioavailability of quercetin and can be a potential application in the treatment of tumor.

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Section: Methodsmentioning

confidence: 99%

“…Quercetin (3,3 ¶,4 ¶,5,7-pentahydroxyflavone) is a naturally occurring flavone found in the plant kingdom. It is a component of most edible fruits and vegetables, with the highest concentrations being found in onions, apples, and red wine (1,2).…”

mentioning

confidence: 99%

Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

Yuan

Chen

Fan

et al. 2006

Clinical Cancer Research

229

164

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“…Evidence for selective toxicity against transformed cells has been presented for polyunsaturated fatty acids (B6gin et al 1986), and also for the compounds l-cyano-2-hydroxy-3-butene, which is found in cruciferous vegetables (Wallig et al 1993) and quercetin (Larocca et al 1991), the latter having been shown to be active in vivo (Castillo et al 1989). We have recently shown that the dietary compound ally1 isothiocyanate, again derived from cruciferous vegetables and a major constituent of mustard, is more toxic towards transformed HT29 human colorectal adenocarcinoma cells than towards cells which have been experimentally detransformed in vitro (Musk & Johnson, 1993~).…”

Section: Selective Cytotoxinsmentioning

confidence: 99%

Anticarcinogenic Factors in Plant Foods: A New Class of Nutrients?

1994

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“…The physiologist Albert Szent Gyorgyi first discovered flavonoids in 1930, and they were soon found to be important in a variety of plant processes, from pigmentation to protection against bacteria and fungi [18]. More than 4000 flavonoids have been described, and their activity in humans is diverse; from scavenging free radicals and modulating enzyme activities, to modifying gene expression and even inducing cellular apoptosis.…”

mentioning

confidence: 99%

“…Quercetin itself has poor water solubility, and is therefore often found stabilized by sugars. Although intestinal absorption is in the range of 30-50%, Quercetin's long half-life of 25 hours suggests high plasma levels are maintainable with proper diet [18]. Moreover, vitamin C has been shown to improve quercetin absorption by the intestine and enhances plasma quercetin levels [19].…”

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confidence: 99%

Quercetin: A Promising Treatment for the Common Cold

Kinker¹,

Comstock

Sajjan³

2014

J Anc Dis Prev Rem

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Rhinovirus infections have afflicted humanity since the dawn of civilization, and are difficult to treat even with modern medicine. Throughout the ages many remedies have been used for the common cold, often caused by the rhinovirus. Recent research points to a flavanol anti-oxidant, quercetin, as having therapeutic properties. Quercetin has been shown to reduce viral internalization and replication in vitro, and viral load, lung inflammation and airways hyper-responsiveness in vivo.

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The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin

Cited by 76 publications

References 20 publications

Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

Liposomal Quercetin Efficiently Suppresses Growth of Solid Tumors in Murine Models

Anticarcinogenic Factors in Plant Foods: A New Class of Nutrients?

Quercetin: A Promising Treatment for the Common Cold

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