The effects of <scp>DASH</scp> diet on weight loss and metabolic status in adults with non‐alcoholic fatty liver disease: a randomized clinical trial

Zade, Mohsen Razavi; Telkabadi, Mohammad; Bahmani, Fereshteh; Salehi, Behnaz; Farshbaf, Shima; Asemi, Zatollah

doi:10.1111/liv.12990

Cited by 228 publications

(228 citation statements)

References 45 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…NAFLD is defined as a systemic, multifactorial disease involving multiple organs, such as adipose tissue, muscle, and intestines [39]. The underlying mechanism for the development and progression of NAFLD is complex and multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Zhou

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis. Our previous studies suggested that resveratrol (RSV) supplement could improve hepatic steatosis, but the underlying mechanism, particularly which related to LD accumulation, has not yet been elucidated. Methods: A high-fat diet (HFD) and palmitic acid were used to induce hepatic steatosis in mouse liver and hepatocytes, respectively. The effects of RSV on LD accumulation were analyzed in vivo and in vitro. The effects of RSV on the expression levels of LD-associated genes (ATF6, Fsp27β/CIDEC, CREBH, and PLIN1) were measured by qRT-PCR and western blot assays, followed by KD or overexpression of SIRT1 and ATF6 with small interfering RNAs or overexpressed plasmids, respectively. The dual luciferase reporter assay, chromatin immunoprecipitation assay, coimmunoprecipitation, and proximity ligation assay were utilized to clarify the mechanism of transcriptional regulation and possible interaction between SIRT1 and ATF6. Results: There was a significant increase in the accumulation of LDs in liver and hepatocytes during the process of HFD-induced steatosis, respectively, which was significantly inhibited by RSV supplementation. RSV notably activated SIRT1 expression and decreased the expression levels of ATF6, Fsp27β/CIDEC, CREBH, and PLIN1, which are associated with LD accumulation. Interestingly, the inhibitory effects of RSV on LD accumulation and the associated expression of genes in hepatocytes were abrogated or strengthened with SIRT1 silencing or overexpression, respectively. On the contrary, the benefits of RSV in hepatocytes were eliminated or aggravated when transfected with the overexpressed ATF6 or ATF6 siRNA, respectively. Furthermore, we found that RSV stimulated SIRT1 expression significantly, which was followed by increased deacetylation and inactivation of ATF6, resulting in a positive feedback loop for SIRT1 transcription associated with ATF6 binding to the SIRT1 promoter region. Conclusion: Taken together, these findings indicate that RSV supplementation improves hepatic steatosis by ameliorating the accumulation of LDs, and this might be partially mediated by a SIRT1/ATF6-dependent mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Zhou

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Initial and followup ultrasounds showed that more patients in the DASH diet group (80% compared with 43.3%, P = 0.003) had a decreased NAFLD grade by ultrasound (53). Patients in the DASH diet group also had more significant decreases in their BMI, insulin and ALT concentrations, serum TGs, and totalto-HDL cholesterol ratio (53). This suggests that caloric restriction alone may be inadequate and that diet type may be more important in improving liver enzymes and hepatic steatosis.…”

mentioning

confidence: 97%

“…In a randomized controlled trial, 60 NAFLD subjects (diagnosed by ultrasound and elevated liver enzymes) were randomly assigned to either the DASH diet or control diet for 8 wk (53). DASH is a sodium-restricted (<2400 mg/d) diet rich in vegetables, fruits, whole grains, and low-fat dairy, and low in saturated fats, cholesterol, refined grains, and sweets.…”

mentioning

confidence: 99%

“…DASH is a sodium-restricted (<2400 mg/d) diet rich in vegetables, fruits, whole grains, and low-fat dairy, and low in saturated fats, cholesterol, refined grains, and sweets. Both groups were calorie-restricted to 350-700 kcal less than the computed energy requirement and had a diet composed of 52-55% carbohydrates, 16-18% proteins, and 30% total fats, but the DASH diet had a higher content of fruits, vegetables, and whole grains (53). Initial and followup ultrasounds showed that more patients in the DASH diet group (80% compared with 43.3%, P = 0.003) had a decreased NAFLD grade by ultrasound (53).…”

mentioning

confidence: 99%

“…Both groups were calorie-restricted to 350-700 kcal less than the computed energy requirement and had a diet composed of 52-55% carbohydrates, 16-18% proteins, and 30% total fats, but the DASH diet had a higher content of fruits, vegetables, and whole grains (53). Initial and followup ultrasounds showed that more patients in the DASH diet group (80% compared with 43.3%, P = 0.003) had a decreased NAFLD grade by ultrasound (53). Patients in the DASH diet group also had more significant decreases in their BMI, insulin and ALT concentrations, serum TGs, and totalto-HDL cholesterol ratio (53).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease

Hsu

Ness

Kowdley

2017

Advances in Nutrition

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) can range in spectrum from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which is characterized by lipotoxicity, hepatocellular ballooning, and inflammation and can progress to cirrhosis. Weight loss is the cornerstone treatment for NAFLD and NASH. Various randomized controlled trials have shown that weight loss of $5-10% leads to significant improvements in hepatic steatosis. Diets high in sodium and fructose have been implicated in the pathogenesis of NAFLD. Although some clinical studies suggest that an isocaloric high-fructose diet does not worsen NAFLD, these clinical studies are often short in duration. More recently, the Dietary Approaches to Stop Hypertension diet, a sodium-restricted diet, has been associated with less prevalence of NAFLD and has been shown to improve NAFLD. In addition, the Mediterranean diet has been promising in improving hepatic steatosis, and a larger randomized controlled trial is currently enrolling subjects. For those who are unable to pursue weight loss through dietary approaches, bariatric surgery has been shown to improve hepatic steatosis and steatohepatitis. This method has been variable in improving hepatic fibrosis. In conclusion, weight loss is crucial to the improvement of NAFLD and NASH, and patients should attempt various diets in an attempt to achieve weight loss. Adv Nutr 2017;8:253-65.

show abstract

Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis

Buzzetti

Linden

Best

et al. 2021

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

The effects of DASH diet on weight loss and metabolic status in adults with non‐alcoholic fatty liver disease: a randomized clinical trial

Abstract: Consumption of DASH diet for 8 weeks among patients with NAFLD had beneficial effects on weight, BMI, ALT, ALP, triglycerides, markers of insulin metabolism, inflammatory markers, GSH and MDA.

Cited by 228 publications

References 45 publications

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease

Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis

Contact Info

Product

Resources

About