The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats

Nassiri‐Asl, Marjan; Mortazavi, S M; Samiee-Rad, Fatemeh; Zangivand, Amir-Abdollah; Safdari, Freshteh; Saroukhani, Sepideh; Abbasi, Esmail

doi:10.1016/j.yebeh.2010.03.005

Cited by 68 publications

(39 citation statements)

References 58 publications

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“…Rutin at doses of 5, 10, and 100 mg/kg significantly increased the memory retrieval in the second retention test of the passive avoidance paradigm, as compared to the control (two days and one week after training). Furthermore, rutin (10 mg/kg) significantly increased the memory retrieval, as compared to the rutin at doses of 100 mg/kg rats in the third retention test of the passive avoidance paradigm (one week after training) [44]. Our study is the first to demonstrate that six weeks of 30 mg/kg rutin administration daily prior to training results in an increased retrieval of memory in D-gal-treated mice, as observed in the first and second retention tests of the passive avoidance test (Figure 6).…”

Section: Discussionmentioning

confidence: 99%

Rutin, a Flavonoid That Is a Main Component ofSaussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Yang

Lin

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Saussurea involucrata (Kar. et Kir.), known as the snow lotus, grows in the Tian Shan and A'er Tai areas of China. It has recently been reported that the ethyl acetate extract of S. involucrata (SI-2) can inhibit proliferation and induce apoptosis in PC-3 human prostate cancer cells. This study investigated the protective effect of ethyl acetate extract of S. involucrata (SI-2) or rutin, a flavonoid extracted from ethyl acetate extract of S. involucrata (SI-2), on D-galactose- (D-gal-) induced brain injury in mice. Administering SI-2 or rutin (30 mg/kg/d and 30 mg/kg/d) for 6 weeks, concomitant with D-gal injection, significantly increased superoxide dismutase and glutathione peroxidase activities and decreased the MDA level in plasma. Furthermore, the result showed that the percentages of cleaved caspase-3 and PARP in the D-gal-treated mice were much higher than those in the control. Pretreatment using SI-2 or rutin decreased the expression of cyclooxygenase-2 via downregulation of NF-kappaB, resulting in a decrease in lipid peroxidation. Furthermore, our results also showed that oral administration of rutin to these mice significantly improved behavioral performance in a step-through passive avoidance task and these results suggest that SI-2 or rutin exerts potent antiaging effects on D-gal in mice via antioxidative mechanisms.

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Section: Discussionmentioning

confidence: 99%

Rutin, a Flavonoid That Is a Main Component ofSaussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Yang

Lin

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…[26]. All doses of rutin were selected as our previous work [18]. This daily dose and the corresponding route have been well characterized with respect to neuropathological expression and neurological deficits.…”

Section: Methodsmentioning

confidence: 99%

Effects of rutin on acrylamide-induced neurotoxicity

et al. 2014

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BackgroundRutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.ResultsRutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).ConclusionIt seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

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“…Chemically it is a glycoside comprising of flavonolic aglycone quercetin along with disaccharide rutinose. It has demonstrated a number of pharmacological activities, including antioxidant, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective and cardioprotective activities [5,6].…”

Section: Introductionmentioning

confidence: 99%

Entrapment of Natural Flavonoids for Microparticulate Drug Delivery System for Hydrophobic Drug Rutin and Hesperidin

Bordoloi¹,

Deb²,

Gogoi³

et al. 2018

Asian J. Chem.

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The aim of this study was to investigate importance of polymeric micro particulate drug delivery system in pharmaceutical field for modifying the drug profile of poorly water-soluble drug rutin and hesperidin. In this study sodium alginate is used as a polymer for entrapping the model drug, which involved the method of ionic cross linking-process. For physico-chemical characterization of the formulations we have studied in vitro drug release drug entrapment efficiency, Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential scanning calorimetric (DSC). In case of hesperidin FH1 is having the minimum drug entrapment efficiency of approximately 69.46 % whereas the entrapment efficiency of FH5 shows an approximate entrapment of 74.28 %. Drug:sodium alginate ratio of 1:2 shows an approximate entrapment of 74.28 %. In case of hesperidin FH2 is having the minimum drug entrapment efficiency of approximately 71.00 % whereas the entrapment efficiency of FH2 shows an approximate entrapment of 75.7 %. This could be revealed as the increase in polymer concentration has significant effect on the drug entrapment efficiency. Drug:sodium alginate ratio of 1:1.2 shows an approximate entrapment of 75.7 %. The FTIR analysis of drug, polymers and the formulations indicated the compatibility of the drug with the polymers. The scanning electron microscopy was used to confirm the smoothness of microspheres formulated. The results of the dissolution study indicated that with the increase in the concentration of sodium alginate in the matrix the amount of drug release appreciably decreased and became steady. The drug-polymer interaction in the microsphere was studied by using differential scanning calorimetry. The release kinetics of the prepared batches of formulation was also studied and was found that the prepared batches followed Higuchi and Krosmayer Peppas release mechanism. The findings of the study suggest that the microsphere formulations is a promising carrier for flavanoids delivery and can be considered as a favourable oral controlled release dosage form for hydrophobic drug rutin and hesperidin.

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The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats

Cited by 68 publications

References 58 publications

Rutin, a Flavonoid That Is a Main Component ofSaussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Rutin, a Flavonoid That Is a Main Component ofSaussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Effects of rutin on acrylamide-induced neurotoxicity

Entrapment of Natural Flavonoids for Microparticulate Drug Delivery System for Hydrophobic Drug Rutin and Hesperidin

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