The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

Mj, Lewis; Groom, G. V.; Barber, R. S.; Henderson, A. H.

doi:10.1111/j.1365-2125.1981.tb01298.x

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…In Experiment 2, propranolol 80 mg induced a significant increase in salivary corticosteroid levels, representing the free portion of the steroid that easily crosses the blood-brain barrier. This finding, also observed in previous animal (Lewis, Groom, Barber, & Henderson, 1981) and human (Kizildere, Glück, Zietz, Schölmerich, & Straub, 2003) studies, raises the intriguing possibility that the impairing effects of propranolol 80 mg on short- and long-term declarative memory may be due, at least in part, to propranolol-induced increases in corticosteroid levels.…”

Section: Discussionsupporting

confidence: 82%

Differential Effects of Adrenergic and Corticosteroid Hormonal Systems on Human Short- and Long-Term Declarative Memory for Emotionally Arousing Material.

Maheu¹,

Joober²,

Beaulieu³

et al. 2004

Behavioral Neuroscience

146

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The effects of adrenergic and corticosteroid hormonal systems on emotional memory were measured in 64 young men. Placebo, propranolol (40 or 80 mg; beta blocker), or metyiapone (corticosteroid synthesis inhibitor) was administered before the viewing of a story composed of emotional and neutral segments. Short- and long-term declarative memory for the story was assessed. Propranolol 40 mg had no effects on declarative memory. Propranolol 80 mg impaired short- and long-term declarative memory for emotionally arousing material. Metyrapone did not impair short-term declarative memory but impaired long-term declarative memory for emotionally arousing and neutral material. Results demonstrate that adrenergic and corticosteroid hormonal systems differentially affect declarative memory for emotionally arousing and neutral material, and suggest that interactions between adrenal hormonal systems modulate emotionally arousing declarative memory in humans.

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Section: Discussionsupporting

confidence: 82%

Differential Effects of Adrenergic and Corticosteroid Hormonal Systems on Human Short- and Long-Term Declarative Memory for Emotionally Arousing Material.

Maheu¹,

Joober²,

Beaulieu³

et al. 2004

Behavioral Neuroscience

146

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“…The rise of cortisol and PRL that occurs in response to insulin hypoglycaemia in normal subjects has been shown to be unchanged by metoprolol, propranolol or alprenolol (Nilsson et al, 1980;Ostman et al, 1982). Lewis et al (1981) (1980) showed that very high doses of propranolol increased PRL. In man a reduction in overnight PRL was demonstrated following propranolol 80 mg twice daily given to healthy male volunteers for 6 weeks (Dart et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Walden¹,

Tomlinson²,

Graham³

et al. 1990

Brit J Clinical Pharma

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1. In order to observe and compare the withdrawal phenomena which follow treatment with the beta‐adrenoceptor blocking drugs, bopindolol (with partial agonist activity PAA) and atenolol (without PAA), two groups of six normal volunteers were studied before, during and after 16 days drug administration. 2. Measurements of plasma levels of cortisol, prolactin, insulin, noradrenaline, adrenaline, glucose and potassium were made during a pre‐treatment baseline period, on maximum dose and for 21 days after drug withdrawal. Isoprenaline infusions were given to determine sensitivity of heart rate responses and haemodynamic changes measured in response to physiological manoeuvres. 3. Following atenolol withdrawal the results show hormonal evidence of adrenergic overactivity in the form of elevation of plasma cortisol, insulin and glucose levels. After bopindolol withdrawal there was, in contrast, an overshoot of plasma prolactin and a persistent elevation of plasma potassium and adrenaline post‐isoprenaline. 4. The hormonal changes which follow withdrawal of atenolol and bopindolol are associated with haemodynamic changes reported elsewhere (Walden et al., 1990). 5. These observations provide confirmatory evidence of a post beta‐adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

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“…The dose of antipsychotic medication was transformed to a chlorpromazine equivalent (mg) according to the defined daily dose of antipsychotics, which were extracted from the Anatomical Therapeutic Chemical Classification Index by the World Health Organization (WHO) Collaborating Center for Drug Statistics Methodology. 28 The subjects were also receiving other concomitant psychotropic medications such as lithium, valproate, benzodiazepine, anticholinergics, and propranolol, which are known to directly and/or indirectly affect serum testosterone level [29][30][31][32][33] and symptoms of schizophrenia. In the placebo group, 3 subjects (20%) compared with 6 subjects (40%) received lithium in the testosterone group; 3 (20%) compared with 2 (13.3%) received valproate; 4 (26.7%) compared with 7 (46.7%) received benzodiazepine; and 3 (20%) compared with 1 (6.7%) received propranolol.…”

Section: Resultsmentioning

confidence: 99%

“…The ethnicity and the short duration also limit the conclusions we are able to draw. There are many factors that affect the serum testosterone levels in men or male schizophrenics, such as psychotropic medications, 26,[29][30][31][32][33] aging, 62 body mass index, 63 stress, 64 diet, 65 exercise, 66 and sexual activity. 67 Although the authors tried to control these confounding factors, they may have influenced the serum levels of testosterone and may have affected the relationship between the serum levels and the symptoms.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Testosterone Augmentation in Male Schizophrenics

Lew²,

Jung

et al. 2008

Journal of Clinical Psychopharmacology

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Although there are few studies on the treatment of schizophrenia with testosterone, several indirect findings have suggested testosterone as a possible treatment modality for schizophrenia. To explore the therapeutic effect of testosterone augmentation of antipsychotic medication on symptoms in male patients with schizophrenia, the authors performed a placebo-controlled, double-blind trial on 30 schizophrenic men, using either 5 g of 1% testosterone gel (Testogel; Besins Iscovesco, Paris, France) or a placebo added to a fixed dosage of antipsychotic medication over a period of 4 weeks with a 2-week washout period. In addition, to get additional information about the involvement of these reproductive hormones after testosterone augmentation, the authors evaluated several hormones such as total testosterone, free testosterone, dehydroepiandrosterone sulfate, estradiol, and prolactin. Results indicated a significant improvement of negative symptoms in both the last observation carried forward and the completer analyses and a nonsignificant trend for the improvement of depressive symptoms in completers. There were no significant changes in serum hormone levels except total and free testosterone. The findings of this study suggest that testosterone augmentation may be a potential therapeutic strategy in patients with schizophrenia.

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The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

Cited by 11 publications

References 15 publications

Differential Effects of Adrenergic and Corticosteroid Hormonal Systems on Human Short- and Long-Term Declarative Memory for Emotionally Arousing Material.

Differential Effects of Adrenergic and Corticosteroid Hormonal Systems on Human Short- and Long-Term Declarative Memory for Emotionally Arousing Material.

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Short-Term Testosterone Augmentation in Male Schizophrenics

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