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Cited by 59 publications
(30 citation statements)
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References 45 publications
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“…Further, other reviews that have been published have reported on the antidepressant properties of probiotics in a mixture of healthy populations, populations under stress, and populations with other primary psychiatric or non-psychiatric diagnoses (e.g., bowel disorders, fibromyalgia, neurodegenerative disorders, etc.) [15][16][17]. However, for probiotics to be considered a viable treatment option for depression, RCT evidence from clinically defined populations with depression rather than with other primary diagnoses is needed.…”
Section: Introductionmentioning
confidence: 99%
“…Further, other reviews that have been published have reported on the antidepressant properties of probiotics in a mixture of healthy populations, populations under stress, and populations with other primary psychiatric or non-psychiatric diagnoses (e.g., bowel disorders, fibromyalgia, neurodegenerative disorders, etc.) [15][16][17]. However, for probiotics to be considered a viable treatment option for depression, RCT evidence from clinically defined populations with depression rather than with other primary diagnoses is needed.…”
Section: Introductionmentioning
confidence: 99%
“…Many independent meta-analyses of randomized, double-blind, placebo-controlled trials that have been conducted over the last two years have reached overlapping conclusions [ 48 , 49 , 50 , 51 , 52 , 53 ]. Probiotics exhibit statistically significant positive effects on the symptoms of depression in humans compared to placebos.…”
Section: Clinical Studies Of Putative Psychobioticsmentioning
confidence: 99%
“…These studies also suggest that the action of probiotics is highly dependent on both the probiotic strain and the target host. For instance, in the study of Amirani et al, the authors summarized that the use of probiotics significantly alleviated the symptoms of patients when rated on the Hamilton Rating Scale for Depression (HDRS) but not on the Beck Depression Inventory (BDI) [ 52 ]. Many factors contribute to whether probiotics will exert any effects at all.…”
Section: Clinical Studies Of Putative Psychobioticsmentioning
confidence: 99%
“…Clinical trials have demonstrated the efficacy of probiotic supplementation in ameliorating mental illness. The clinical efficacy of probiotics coupled with their lack of detrimental side effects and stigmatization make them a promising therapeutic intervention in mental disorders [26][27][28][29]. Although existing clinical trials are limited and more substantial research outcomes are needed, probiotics are a noteworthy therapeutic intervention as far as the mental health domain is concerned.…”
Section: Introductionmentioning
confidence: 99%
“…Recent metaanalyses and systematic reviews have substantiated the efficacy of probiotic supplementation in the treatment of depressive disorder in human subjects. Depression scores based on validated clinical scales and certain biomarkers associated with depression including cortisol, proinflammatory cytokines and brain-derived neurotrophic factor (BDNF) levels were used to demonstrate the anti-depressive effect of probiotic intervention [25,27,30,31]. Clinical trials of probiotics in patients with depression, although limited compared to pre-clinical studies, have demonstrated comparable outcome in terms of mediating antidepressive effects, especially studies involving the measurement of biomarkers [18,[32][33][34][35].…”
Section: Introductionmentioning
confidence: 99%