The effects of probiotic supplement on hemoglobin in chronic renal failure patients under hemodialysis: A randomized clinical trial

Abstract

Background:Chronic inflammation is one of the causes of anemia in chronic renal failure patients under hemodialysis. Probiotics probably establish a balance between pro- and anti-inflammatory cytokines. The study was conducted to determine the effects of probiotic supplementation on hemoglobin (Hb) in hemodialysis patients.Materials and Methods:A parallel clinical trial was conducted in which patients were randomly allocated into two groups. The intervention group (n = 18) was given a 500 mg probiotic supplement (a capsule) every day whereas the control group (n = 18) received placebo (a capsule), both for 3 months. Hb levels and C-reactive protein (CRP) levels were measured for three periods. The data were analyzed in SPSS-16 using statistical tests including the t-test and repeated-measures ANOVA.Results:In the probiotic supplementation group, the mean Hb was 9.22 ± 1.04 mg/dl before the intervention and reached 10.85 ± 1.177 mg/dl afterward, while in the placebo group, the mean Hb level was 9.38 ± 0.97 mg/dl before the intervention and reached 10.03 ± 1.97 mg/dl afterward (P > 0.05). During the study, the placebo caused to increase of Hb temporary, but in longer term, the effect of probiotic was more manifested. Hb levels increased in both groups although the change was not statistically significant (P > 0.05). The findings showed no significant differences between the two groups in either the pre- or post-intervention CRP levels (P = 0.239).Conclusion:Probiotic supplementation decreased Hb fluctuations in hemodialysis patients but did not result in a significant increase in Hb levels. Similar studies are therefore recommended to be conducted with a prolonged duration of the study or an increased probiotic dose with larger sample size to complete the results of the present study.

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

“…Some studies related this to the stimulation of the haematopoietic organs [ 69 ] and also to the indirect effect of some lactic acid bacteria, including Lactobacilli , by increasing the bioavailability of dietary iron through several mechanisms such as the reduction of intestinal pH [ 70 ]. In agreement with our findings, the use of Lactobacillus rhamnosus for a period of three months in combination with other probiotic strains ( Lactobacillus acidophilus , Lactobacillus casei , Lactobacillus bulgaricus , Bifidobacterium breve , Bifidobacterium longum , and Streptococcus thermophilus ), increased the level of haemoglobin remarkably [ 71 ]. In contrast, other studies have noted that the treatment with Pediococcus acidilactici at a concentration of 10 9 cfu/g does not affect the erythrogram of broilers [ 72 ].…”

The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial

“…In another trial, however, a 12-week supplementation of hemodialysis patients with a multi-strain probiotic preparation did not affect the hemoglobin status; the inefficacy of probiotics in the improvement of inflammation was considered responsible for this result. [ 50 ] Probiotic administration also showed no positive effect on Hb level in HIV patients and healthy elders in the other trials. [ 52 53 ]…”

“…Anemia and low Hb level associated with declining renal function is another common complication of CKD that may negatively affect the quality of life. [ 50 ] The mean Hb level showed a significant increasing trend in patients supplemented with probiotic or synbiotic formulations, while Hb level variability was observed in the placebo group. Considering the potential role of inflammation in CKD-anemia and Hb fluctuation,[ 47 48 ] the anti-inflammatory activity of probiotic strains observed in our previous studies[ 23 40 ] may explain these findings.…”

Impact of hot stone massage therapy on sleep quality in patients on maintenance hemodialysis: A randomized controlled trial

“…The progression of chronic renal failure toward end-stage renal disease is increasing. [1] It is reported that the rate of mortality in chronic hemodialysis is 7–8 times greater than the general population. [2]…”