The Effects of Primary Brain Tumors on Vision and Quality of Life in Pediatric Patients

Jariyakosol, Supharat; Peragallo, Jason H.

doi:10.1055/s-0035-1563571

Cited by 24 publications

(34 citation statements)

References 49 publications

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“…The upper age of 24 years can arguably be defended by pointing to the well-known transition of BT types around this age. Because we excluded children below 10 years of age, our results are less affected by age-related difficulties to identify and specify symptoms [34]. Another limitation is the omission of information about the time of day symptoms occurred (a shortcoming for headaches that, when occurring in the morning, are considered to be more likely related to BTs).…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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Introduction We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

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Section: Discussionmentioning

confidence: 99%

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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“…Visual problems may be reversible in early stages of visual impairment. Therefore, timely monitoring of visual function and early detection of visual impairment in children with CP is of major importance to preserve visual function and provide adequate treatment [12,13,17,18,20]. In children with irreversible visual impairment, timely referral for visual rehabilitation may reduce the adverse effects of visual impairment on health and/or vision related quality of life [115,116].…”

Section: Discussionmentioning

confidence: 99%

“…Damage of the visual pathway commonly manifests as decreased visual acuity (VA), visual field (VF) defects, typically bitemporal hemianopia, and/ or abnormal pupillary reponses [5][6][7][8][9][10][11]. Increased intracranial pressure as a result of obstructive mass effect of the tumour can lead to papilledema with subsequent optic atrophy and permanent vision loss as potential complications [8,12,13]. In addition, therapeutic interventions for CP such as tumour resection or post-surgical radiation therapy can lead to further visual loss.…”

Section: Introductionmentioning

confidence: 99%

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Visual functions in children with craniopharyngioma at diagnosis: A systematic review

et al. 2020

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Childhood craniopharyngioma is a rare and slow growing brain tumour, often located in the sellar and suprasellar region. It commonly manifests with visual impairment, increased intracranial pressure and hypothalamic and/or pituitary deficiencies. Visual impairment in childhood adversely affects a child's daily functioning and quality of life. We systematically reviewed the literature to provide an extensive overview of the visual function in children with craniopharyngioma at diagnosis in order to estimate the diversity, magnitude and relevance of the problem of visual impairment. Of the 543 potentially relevant articles, 84 studies met our inclusion criteria. Visual impairment at diagnosis was reported in 1041 of 2071 children (50.3%), decreased visual acuity was reported in 546 of 1321 children (41.3%) and visual field defects were reported in 426 of 1111 children (38.3%). Other ophthalmological findings described were fundoscopic (32.5%) and orthoptic abnormalities (12.5%). Variations in ophthalmological testing methods and ophthalmological definitions precluded a meta-analysis. The results of this review confirm the importance of ophthalmological examination in children with craniopharyngioma at diagnosis in order to detect visual impairment and provide adequate support. Future studies should focus on long-term visual follow-up of childhood craniopharyngioma in response to different treatment strategies to provide insight in risks and ways to prevent further loss of vision.

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“…5,6 Children are more often having their care transitioned to long-term survivorship clinics as they are surviving their primary disease, and in such settings outcome measures tend to be geared more toward quality of life measures than survival alone. 7,8…”

Section: Demographicsmentioning

confidence: 99%

Visual function in children with primary brain tumors

Peragallo

2019

Current Opinion in Neurology

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Purpose of review: To review the recent advances in understanding how primary brain tumors affect vision in children. Recent findings: Children with primary brain tumors may have vision loss due to involvement of their afferent visual pathways or from papilledema. These vision deficits may go unrecognized until later in life, years after treatment of the primary lesion. Strabismus and cranial nerve palsies may occur as a result of brain tumors. Ophthalmologists can monitor and treat young children at risk for vision loss from amblyopia as a result of effects from their underlying lesion. Advances in imaging techniques have made it possible to quantify damage to the visual pathways with objective tests. Summary: Systematic referrals for evaluation by an ophthalmologist should occur early in the course of treatment of primary brain tumors as these evaluations may improve visual outcomes and quality of life.

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The Effects of Primary Brain Tumors on Vision and Quality of Life in Pediatric Patients

Cited by 24 publications

References 49 publications

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Visual functions in children with craniopharyngioma at diagnosis: A systematic review

Visual function in children with primary brain tumors

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