The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

Negera, Edessa; Tilahun, Melaku; Bobosha, Kidist; Lambert, S. M.; Walker, Stephen L.; Spencer, John S.; Aseffa, Abraham; Dockrell, Hazel M.

doi:10.1371/journal.pntd.0007035

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A worrying fact, since the Brazilian Longitudinal Multicentric Study of Adult Health (ELSA Brazil) [55] classified as desirable levels of HDL-cholesterol �40 mg/dL for men and �50 mg/dL for women. These data are in agreement with recent findings from Silva et al (2018) and Negera et al (2018), which also observed lower levels of HDL-cholesterol in Mb patients compared to Pb and HC [56,57]. Other studies on serum lipids in leprosy also described lower levels of HDL-cholesterol in Mb patients [58,59].…”

Section: Discussionsupporting

confidence: 92%

Altered composition and functional profile of high-density lipoprotein in leprosy patients

et al. 2020

View full text Add to dashboard Cite

The changes in host lipid metabolism during leprosy have been correlated to fatty acid alterations in serum and with high-density lipoprotein (HDL) dysfunctionality. This is most evident in multibacillary leprosy patients (Mb), who present an accumulation of host lipids in Schwann cells and macrophages. This accumulation in host peripheral tissues should be withdrawn by HDL, but it is unclear why this lipoprotein from Mb patients loses this function. To investigate HDL metabolism changes during the course of leprosy, HDL composition and functionality of Mb, Pb patients (paucibacillary) pre-or post-multidrug therapy (MDT) and HC (healthy controls) were analyzed. Mb pre-MDT patients presented lower levels of HDLcholesterol compared to HC. Moreover, Ultra Performance Liquid Chromatography-Mass Spectrometry lipidomics of HDL showed an altered lipid profile of Mb pre-MDT compared to HC and Pb patients. In functional tests, HDL from Mb pre-MDT patients showed impaired anti-inflammatory and anti-oxidative stress activities and a lower cholesterol acceptor capacity compared to other groups. Mb pre-MDT showed lower concentrations of ApoA-I (apolipoprotein A-I), the major HDL protein, when compared to HC, with a post-MDT recovery. Changes in ApoA-I expression could also be observed in M. leprae-infected hepatic cells. The presence of bacilli in the liver of a Mb patient, along with cell damage, indicated hepatic involvement during leprosy, which may reflect on ApoA-I expression. Together, altered compositional and functional profiles observed on HDL of Mb patients can explain metabolic and physiological changes observed in Mb leprosy, contributing to a better understanding of its pathogenesis.

show abstract

Section: Discussionsupporting

confidence: 92%

Altered composition and functional profile of high-density lipoprotein in leprosy patients

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In addition, senescence in immune cells can induce immunosenescence, compromising the immune surveillance of NSCLC patients and increasing the risk of cancer-related adverse events such as cancer recurrence or cancer-specific death [ 34 , 35 , 36 ]. In addition, chronic inflammation, which is tightly connected to the pathogenesis of many chronic diseases [ 37 , 38 , 39 , 40 , 41 ], can negatively impact postsurgical outcomes and cancer prognosis; this can also partially explain why NSCLC patients with a higher burden of comorbidities have shorter survival. Further, NSCLC patients—particularly those with pre-existing chronic conditions—are often at risk of cardiac and/or respiratory complications, including but not limited to pneumonia, atrial fibrillation, and venous thromboembolism [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Survival Differences by Comorbidity Burden among Patients with Stage I/II Non-Small-Cell Lung Cancer after Thoracoscopic Resection

Wheeler

Karanth

Mehta

et al. 2023

Cancers

View full text Add to dashboard Cite

We sought to compare overall survival (OS) by comorbidity burden among patients with stage I/II non-small cell lung cancer (NSCLC) who received thoracoscopic resection. Utilizing data from the National Cancer Database, we conducted a survival analysis among patients aged 50+ with stage I/II NSCLC who received thoracoscopic resection between 2010 and 2017. The comorbidity burden was measured by the Charlson comorbidity index (CCI, 0, 1, 2+). Multivariable Cox proportional hazard models were used to compare overall survival relative to the CCI (CCI of 0 as the referent). Subgroup analyses were conducted considering sex, age groups, days from diagnosis to surgery, facility type, laterality, and type of surgery. For this study, 61,760 patients were included, with a mean age of 69.1 years (SD: 8.5). Notably, 51.2% had a CCI of 0, 31.8% had a CCI of 1, and 17.0% had a CCI of 2+. Most participants were non-Hispanic White (87.5%), and 56.9% were female. We found that an increase in the CCI was associated with a higher risk of all-cause mortality (CCI 1 vs. 0 aHR: 1.24, 95% CI: 1.20–1.28; CCI 2+ vs. 0 aHR: 1.51, 95% CI: 1.45–1.57; p-trend < 0.01). Our subgroup analysis according to sex suggested that the association between CCI and risk of death was stronger in women.

show abstract

“…Same with research conducted by Zenha and his collage which states that there is a decrease in bacterial index in leprosy patients who have received MDT therapy for 12-24 months. 14 The study conducted by Negera (2018) 15 stated that the use of prednisolone in people with leprosy who experienced a reaction could reduce the antibody to M. leprae. In this case, pprednisolones treatment after 1 month decreased productivity from IL-10.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Serum Interleukin 10 Levels between Leprosy and Non-Leprosy Population

Kodrati¹,

Salim²,

Hafy³

2021

MMJKK

View full text Add to dashboard Cite

Leprosy is a chronic granulomatous infectious disease that attacks the peripheral nerves, skin, and other organs. The cytokine IL-10 can deactivate macrophages, inhibit IL-12 production, which also inhibits IFN-ϒ production. IL-10 directly inhibits CD4+T cells and antigen-presenting cell (APC) function in cells infected with M. leprae. The purpose of this study was to determine the differences in IL-10 levels in leprosy patients and non-patients at dr. Mohammad Hoesin Palembang Hospital. This study used a case-control design for comparing 2 groups. Respondents in this study were 80 people. The case samples were all leprosy patients who were treated at the dr. Mohammad Hoesin Hospital, Palembang for the period of January 16 - February 16, 2019, while the control group was medical personnel and paramedics who worked at the same hospital. The examination was carried out using the ELISA Sandwich method. The results showed that there was a significant difference in IL-10 levels between leprosy patients and non-leprosy leprosy (p=0.000). The average IL-10 level in leprosy patients (13.24 pg/ml) was lower than that in non-patients (40.15 pg/ml). It is concluded that there is a difference in IL-10 levels between leprosy patients and non-leprosy patients in leprosy sufferers are lower than non-leprosy persons.

show abstract

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

Cited by 6 publications

References 28 publications

Altered composition and functional profile of high-density lipoprotein in leprosy patients

Altered composition and functional profile of high-density lipoprotein in leprosy patients

Survival Differences by Comorbidity Burden among Patients with Stage I/II Non-Small-Cell Lung Cancer after Thoracoscopic Resection

Comparison of Serum Interleukin 10 Levels between Leprosy and Non-Leprosy Population

Contact Info

Product

Resources

About