The Effects of Oxidative Stress on the Redox System of the Human Erythrocyte

Öğüş, I. Hamdi; Balk, Mevhibe; Aksoy, Yasemin; Müftüoğlu, Meltem; Özer, Nazmi

doi:10.1007/978-1-4757-2907-8_3

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An additional experiment was carried out on seedlings treated with sodium azide (NaN 3 ) (used as positive control), a known superoxide dismutase (SOD) and catalase (CAT) inhibitor (ED 50 = 1 mM and 25 μM, respectively) [23,24,25,26,27], using the following concentrations: 0, 25, 50, 100, 200, 400 and 800 μM.…”

Section: Methodsmentioning

confidence: 99%

Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction

et al. 2018

View full text Add to dashboard Cite

Phytotoxic potential of rosmarinic acid (RA), a caffeic acid ester largely found in aromatic species, was evaluated on Arabidopsis through metabolomic and microscopic approaches. In-vitro bioassays pointed out that RA affected root growth and morphology, causing ROS burst, ROS scavengers activity inhibition and consequently, an alteration on cells organization and ultrastructure. In particular, RA-treatment (175 μM) caused strong vacuolization, alteration of mitochondria structure and function and a consistent ROS-induced reduction of their transmembrane potential (ΔΨm). These data suggested a cell energy deficit also confirmed by the metabolomic analysis, which highlighted a strong alteration of both TCA cycle and amino acids metabolism. Moreover, the increase in H2O2 and O2− contents suggested that RA-treated meristems underwent oxidative stress, resulting in apoptotic bodies and necrotic cells. Taken together, these results suggest that RA inhibits two of the main ROS scavengers causing high ROS accumulation, responsible of the alterations on mitochondrial ultrastructure and activity through ΔΨm dissipation, TCA-cycle alteration, cell starvation and consequently cell death on Arabidopsis seedlings. All these effects resulted in a strong inhibition on root growth and development, which convert RA in a promising molecule to be explored for further use in weed management.

show abstract

Section: Methodsmentioning

confidence: 99%

Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction

et al. 2018

View full text Add to dashboard Cite

show abstract

The Relevance of Glutathione Reductase Inhibition by Fluoxetine to Human Health and Disease: Insights Derived from a Combined Kinetic and Docking Study

et al. 2019

View full text Add to dashboard Cite

The role of free oxygen radicals in the aetiopathogenesis of rosacea

Öztaş

Balk

Öğüş

et al. 2003

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

A possible link between superoxide dismutase activity and malondialdehyde level with the clinical manifestations of rosacea was investigated. We found differences in superoxide dismutase activities between mild rosacea (stages I and II) and severe involvement (stage III) groups, as well as between disease and control groups that were statistically significant (P < 0.05). In the mild involvement group (stages I and II), the superoxide dismutase activity was higher than in the control group (P < 0.05), while the malondialdehyde levels did not differ from the control. In the severe involvement group (stage III), the superoxide dismutase activity was lower than in the control group (P < 0.05), and this was coupled to a raised level of malondialdehyde (P < 0.05). These findings clearly show that in the mild involvement phase of rosacea patients, superoxide dismutase activity was stimulated to protect the skin against reactive oxygen species so that the malondialdehyde levels were maintained. In contrast, in more severe disease, due to a decrease in the capacity of the antioxidant defence system, the malondialdehyde levels were increased. These findings support the 'antioxidant system defect hypothesis' in rosacea patients.

show abstract

The Effects of Oxidative Stress on the Redox System of the Human Erythrocyte

Cited by 3 publications

References 17 publications

Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction

Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction

The Relevance of Glutathione Reductase Inhibition by Fluoxetine to Human Health and Disease: Insights Derived from a Combined Kinetic and Docking Study

The role of free oxygen radicals in the aetiopathogenesis of rosacea

Contact Info

Product

Resources

About