The Effects of Nanodiamonds at the Action of Colored Metal Ions on the Skin of Guinea Pigs

Abstract

The protective effect of modified nanodiamonds (MND) under the action of cobalt and nickel ions on the skin of Guinea pigs was shown. At the action of chromium ions on the skin of animals, the protective effect of MND was not found. The differences are related to different adsorption properties of MND to the investigated colored metal ions. It is shown in vitro that MND can adsorb ions of cobalt and nickel and don't bind ions of chromium from aqueous medium. The perspectives using of MND as a new drug for the prevention allergic dermatitis caused by action of bivalent ions of metals are discussed.

pH Sensitive Dextran Coated Fluorescent Nanodiamonds as a Biomarker for HeLa Cells Endocytic Pathway and Increased Cellular Uptake

“…Additionally, no adverse effects have been observed in several in vivo experiments [ 11 , 12 ]. FNDs were, for instance, used for drug delivery in animal models like mice [ 13 ], fruit flies, worms, or pigs [ 14 ]. Chow et al showed that the nanodiamond drug delivery system improved both drug retention in tumour cells and treatment safety and efficacy in murine cancer models for tumour treatment [ 15 ].…”

One step synthesis of a bimetallic (Ni and Co) metal–organic framework for the efficient electrocatalytic oxidation of water and hydrazine

“…S7) of Co-MOF and Ni-MOF show broad peaks centered at around 524 and 395 nm, respectively, which arise due to the d–d transition and these peak positions are consistent with the octahedral coordination sphere. 39,40 A regular increase in the intensity of the 524 nm band on increasing the mole ratio of Co and similarly a regular increase in the intensity of the 395 nm band on increasing the mole ratio of Ni are distinctly observed. These results match well with the ratio of starting precursors and EDAX data.…”

A Comprehensive Assessment of the Biocompatibility and Safety of Diamond Nanoparticles on Reconstructed Human Epidermis

“…Moreover, prolonged exposure to modified nanodiamonds exerts a protective effect on the skin of guinea pigs treated with nickel and cobalt ions. This reduces the probability of an allergic reaction, which often occurs as a result of irritation [ 16 , 53 ]. However, the comparison between human and mouse skin tissue highlights the presence of significant species differences, emphasizing the importance of considering these variations when utilizing mice as a substitute model for understanding human physiology [ 54 ].…”