The Effects of Moringa oleifera Leaves Extracts on Sickle Cell Hemoglobin

Nwaoguikpe, R. N.; Ujowundu, C. O.; Igwe, C. U.; Dike, Priscilla

doi:10.9734/jsrr/2015/12905

Cited by 6 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zinc and vitamin C assist in protecting and boosting the haematologic indices of the blood as well as the immune system 25 , while the iron is required for HGB formation. Thus, the observed significant increases in PCV and HGB could be attributed to the reported high contents of minerals, vitamins and amino acids in M. oleifera 9,26 .…”

Section: Resultsmentioning

confidence: 89%

“…Moringa oleifera has been used for biomass, biogas, gum, pulp, dye and biopesticides production as well as a domestic cleaning agent and juice-clarifier 7 . Various parts of the plant have been reported to act as cardiac and circulatory stimulants, possess antitumor, antipyretic, antiepileptic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol-lowering, antioxidant, anti-diabetic, antibacterial and antifungal activities 8 as well as anti-sickling 9 and anti-poison 10 effects.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Igwe¹,

Ezerioha²,

Iheme³

et al. 2022

J. of Applied Sciences

View full text Add to dashboard Cite

Background and Objective: Moringa oleifera is a widely acclaimed ʻmiracle plantʼ whose medicinal and nutritional importance require documentation. The effect of Moringa oleifera leaf powder (MOLP) intake on haematologic, hepatic and renal function indices was studied using standard methods. Materials and Methods: Twenty-four Albino rabbits, weighing 0.9-1.8 kg, were distributed into group I animals fed the control diet and groups II-IV fed 500, 750 and 1000 mg kgG 1 b.wt., of MOLP, respectively for 28 days. Feed intake and body weights of the animals were measured daily. Results: Groups fed 500 and 750 mg kgG 1 of MOLP consumed more of the feed and showed a non-significant (p>0.05) but a more progressive increase in mean body weights. Intake of MOLP did not significantly (p>0.05) alter most of the biochemical and hematologic indices studied but serum total protein, albumin and haemoglobin concentrations increased significantly (p<0.05), while red blood cell indices increased non-significantly (p>0.05) with the increase in MOLP dosage. Generally, 500 and 750 mg kgG 1 MOLP diets gave better positive indices than 1000 mg kgG 1 MOLP. Conclusion: Apparently, MOLP intake has no harmful effects on the liver, kidney and blood parameters of animals but may enhance the building capacity, repair and maintenance of body tissues. However, the study calls for caution in the use of very high doses.

show abstract

Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Igwe¹,

Ezerioha²,

Iheme³

et al. 2022

J. of Applied Sciences

View full text Add to dashboard Cite

show abstract

“…They found that women with iron deficiency anaemia could benefit from taking Moringa leaves extract. Moringa oleifera leaves were tested for antisickling effects on sickle cell haemoglobin by Nwaoguikpe et al, 2015. There were 88.88% for the WAS (water-soluble) fraction up to 98.35% for the FAS (fatsoluble) fraction antisickling effects found by the researchers.…”

Section: Research Evidence Of the Efficacy Of M Oleifera In Blood-rel...mentioning

confidence: 92%

A Review on Significance of Moringa oleifera in the Treatment of Heme-Related Disorders and Malnutrition

2022

pnr

View full text Add to dashboard Cite

The Moringa plant is widely grown worldwide because of its ability to withstand both drought and frost. It has ethnopharmacological significance, as Moringa oleifera thrives in tropical and subtropical areas. This plant has two common names: "drumstick tree" and "horseradish tree." It is possible to eat or sell every part of the tree because of its high nutritional value. This review's objective is to examine the phytochemical composition, therapeutic uses, and pharmacological features of this tree species that serve to treat hematological disorders. There was a thorough search of all of the scholarly databases, including PubMed, Scopus, Google Scholar and ACS, and published books. Vitamins, minerals, and phytochemicals abound in the leaves. Lactating moms may benefit from leaf extracts, which are routinely used to treat malnutrition. It is being researched as an anticancer, antioxidant, anti-diabetic, anti-inflammatory, and antibacterial agent. Natural coagulant M. oleifera seed is utilized in water purification. Even in commercial products, Moringa could be employed to boost the nutritional value or treat ailments like diabetes and cancer, for example. Several elements of commercial, nutritional, and cultivation of Moringa are explored in this article. M. oleifera plant can be used as a nutritional supplement in the treatment of heme-related disorder and malnutrition.

show abstract

“…[19][20][21] The leaves used for animal and human feeding, given their alleged richness in proteins, vitamins, b-carotene, and amino acids, are now considered a functional food. 14,19,[21][22][23][24][25] A wide variety of medicinal uses have been attributed to M. oleifera's various organs for anti-inflammatory, anti-infectious, cardiovascular, gastrointestinal and hematological properties, including the management of sickle cell disease. 14,19,21,24 Phytochemical studies reported the highest level of phenolic compounds, mainly flavonoids, in M. oleifera leaves.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Biological Activities of Drepanoalpha® Ethanolic Extract, A Justicia Secunda and Moringa Oleifera-Based Phytomedicine Proposed for The Symptomatic Treatment of Sickle Cell Disease

Zoawe

Nachtergael

Tshibangu

et al. 2023

JFAPS

View full text Add to dashboard Cite

Sickle cell disease (SCD) is an autosomal recessive blood disorder characterized by red blood cells that assume an abnormal, rigid sickle shape under low-oxygen conditions. These sickle-shaped erythrocytes tend to lyse, aggregate, and obstruct small blood vessels, leading to major complications. The present study aims to investigate properties that may underlie the activity of Drepanoalphaâ, an antisickling herbal formulation developed in the Democratic Republic of Congo (DRC) for the prevention and symptomatic treatment of sickle cell disease crises. The Drepanoalpha® Ethanolic Extract (DEE) is a dry extract (drug-extract ratio, DER, 100/11) prepared from ethanol (96 %, v/v) percolation of a 1:1 mixture of 2 food plants, Justicia secunda Vahl and Moringa oleifera Lam. Sickling was classically measured by light microscopy on diluted washed erythrocytes obtained from homozygote patients; erythrocytes were treated with 2 % Na2S2O5 in the presence of DEE (suspension in 9 ‰ NaCl), 9 ‰ NaCl (negative control) or disodium cromoglycate (DSCG, positive control). For all tested conditions, the sickle hemoglobin polymerization, the Fe2+/Fe3+ ratio, and the median corpuscular fragility were measured by spectrophotometry. The DEE reversed sickling by 89.1 %, comparable to DSCG (87.7 %; 60.3 µg/mL), inhibiting sickle cell hemoglobin polymerization of 77.8 % and 74.4 %, respectively. The Fe2+/Fe3+ ratio was improved by 18.0 % for DEE and 15.9 % for DSCG. The median corpuscular fragility values were 0.602, 0.714, and 0.732 for NaCl 9 ‰, DSCG, and DEE, respectively. The measured in vitro parameters validate an effective antisickling effect of DEE and confirm the value of this improved traditional herbal formulation for the management of SCD.

show abstract

The Effects of Moringa oleifera Leaves Extracts on Sickle Cell Hemoglobin

Cited by 6 publications

References 17 publications

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

A Review on Significance of Moringa oleifera in the Treatment of Heme-Related Disorders and Malnutrition

In Vitro Biological Activities of Drepanoalpha® Ethanolic Extract, A Justicia Secunda and Moringa Oleifera-Based Phytomedicine Proposed for The Symptomatic Treatment of Sickle Cell Disease

Contact Info

Product

Resources

About