The Effects of Magnesium Supplementation on Lipid Profile Among Type 2 Diabetes Patients: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Asbaghi, Omid; Moradi, Sajjad; Nezamoleslami, Shokufeh; Moosavian, Seyedeh Parisa; Kermani, Mohammad Ali Hojjati; Lazaridi, A.V.; Miraghajani, Maryam

doi:10.1007/s12011-020-02209-5

Cited by 19 publications

(16 citation statements)

References 46 publications

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“…One earlier meta-analysis study suggested no significant effects of Mg supplementation on the lipid profiles among individuals with or without diabetes (43). However, one recent meta-analysis study concluded that Mg supplementation could significantly lower the LDL level in patients with diabetes (44). These different findings may be accounted for the blood Mg levels of the population enrolled in our study being higher than those of patients with diabetes, chronic kidney disease, or hypomagnesemia (3,42,44).…”

Section: Discussioncontrasting

confidence: 59%

“…However, one recent meta-analysis study concluded that Mg supplementation could significantly lower the LDL level in patients with diabetes (44). These different findings may be accounted for the blood Mg levels of the population enrolled in our study being higher than those of patients with diabetes, chronic kidney disease, or hypomagnesemia (3,42,44). It indicates that overindulging or unnecessary Mg supplementation may harm lipid profiles.…”

Section: Discussioncontrasting

confidence: 56%

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Single and combined associations of blood lead and essential metals with serum lipid profiles in community-dwelling adults

et al. 2023

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BackgroundAlthough several studies have examined the relationships between lead (Pb) exposure and serum lipid profiles, the associations of the metal mixture, including lead (Pb) and essential metals with lipid profiles, remain unclear.ObjectiveTo investigate the associations of the metal mixture including Pb and essential metals [magnesium (Mg), manganese (Mn), copper (Cu), iron (Fe), zinc (Zn), and calcium (Ca)] with serum lipid profiles [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], as well as the potential interactions among the metals.MethodsNine hundred and ninety-eight Chinese community-dwelling adults completed a questionnaire and underwent checkups of anthropometric parameters, serum lipid profile levels (TC, TG, LDL-C, and HDL-C), and blood metal concentrations (Pb, Mg, Mn, Cu, Fe, Zn, and Ca). The multivariable linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were applied to evaluate the single and combined associations of blood Pb and essential metals with serum lipid profiles.ResultsIn the multivariable linear regression model, the blood Pb was positively associated with TC, LDL-C, and HDL-C (p < 0.05, all), and the blood Mg were positively associated with serum TC, LDL-C, and Ln TG (p < 0.05, all). In the WQS regression and BKMR models, the metal mixture of blood Pb and the essential metals was positively associated with all of the serum lipid profiles. In addition, an inverse U-shaped association of Pb with Ln TG and the positive interactive effect between blood Pb and Mg levels on TC and LDL-C were found.ConclusionThe levels of blood Pb, together with the essential metals, especially Mg levels, are suggested to be considered when assessing dyslipidemia risk. However, more evidence is still needed to validate the conclusions.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussioncontrasting

confidence: 56%

Single and combined associations of blood lead and essential metals with serum lipid profiles in community-dwelling adults

et al. 2023

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“…In the human body, magnesium is a cofactor in several enzyme systems such as Na + /K + -ATPase, hexokinase, creatine kinase, protein kinase. Also, magnesium plays a role in signal transduction, protein synthesis, neuromuscular conduction,, muscle and nerve transmission, blood glucose control, and blood pressure regulation [ 37 38 39 ]. Abnormal magnesium homeostasis can lead to metabolic disorders, such as diabetes [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zamani

Haghighat

2022

Clin Nutr Res

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The aim of this systematic review and meta-analysis was to summarize all the existing randomized controlled trials (RCTs) evidence and to evaluate the effects of magnesium supplementation on serum magnesium, calcium and urinary magnesium concentrations in patients with type 2 diabetes compared with the control. Two independent authors systematically searched online databases including Embase, Scopus, PubMed, and Web of Science from inception until 30th January 2022. RCTs complying with the inclusion criteria were included in this meta-analysis. The heterogeneity among the included studies was assessed using Cochrane’s Q test and I-square (I 2 ) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Sixteen trials were included in this meta-analysis. Serum magnesium (mean difference, 0.15 mg/dL; 95% confidence interval [CI], 0.06 to 0.23; p = 0.001) and urinary magnesium (WMD, 1.99 mg/dL; 95% CI, 0.36 to 3.62; p = 0.017) concentrations were significantly increased after magnesium supplementation when compared with the control group. However, magnesium supplementation did not have any significant effect on serum calcium (WMD, −0.09 mg/dL; 95% CI, −0.27 to 0.08; p = 0.294) level when compared with the control group. This meta-analysis demonstrated that magnesium supplementation significantly increased Serum magnesium levels which may have played an indirect role in improved clinical symptoms in patients with type 2 diabetes.

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“…Mg is an important factor in CKD mineral bone disorders (CKD-MBD) as it can suppress parathyroid hormone (PTH) secretion, activate the calcium-sensing receptor, promote osteoblast activity, and reduce intestinal phosphate absorption [ 40 , 70 , 71 ]. Although low Mg levels stimulate PTH secretion, Mg is also required for the production and release of PTH and therefore severe hypomagnesemia can lead to clinical hypocalcemia via hypoparathyroidism [ 72 , 95 ]. For these reasons, administration of Mg is of interest for its potential to modify CKD-MBD.…”

Section: Magnesium Administration To Improve Healthmentioning

confidence: 99%

Magnesium Administration in Chronic Kidney Disease

Vermeulen

Vervloet

2023

Nutrients

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Awareness of the clinical relevance of magnesium in medicine has increased over the last years, especially for people with chronic kidney disease (CKD), due to magnesium’s role in vascular calcification and mineral metabolism. The inverse association between serum magnesium and clinically relevant, adverse outcomes is well-established in people with CKD. Subsequent intervention studies have focused on the effect of magnesium administration, mainly in relation to cardiovascular diseases, mineral bone metabolism, and other metabolic parameters. The most commonly used routes of magnesium administration are orally and by increasing dialysate magnesium. Several oral magnesium formulations are available and the daily dosage of elemental magnesium varies highly between studies, causing considerable heterogeneity. Although data are still limited, several clinical studies demonstrated that magnesium administration could improve parameters of vascular function and calcification and mineral metabolism in people with CKD. Current clinical research has shown that magnesium administration in people with CKD is safe, without concerns for severe hypermagnesemia or negative interference with bone metabolism. It should be noted that there are several ongoing magnesium intervention studies that will contribute to the increasing knowledge on the potential of magnesium administration in people with CKD.

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The Effects of Magnesium Supplementation on Lipid Profile Among Type 2 Diabetes Patients: a Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 19 publications

References 46 publications

Single and combined associations of blood lead and essential metals with serum lipid profiles in community-dwelling adults

Single and combined associations of blood lead and essential metals with serum lipid profiles in community-dwelling adults

The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Magnesium Administration in Chronic Kidney Disease

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