The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zamani, Mohammad; Haghighat, Neda

doi:10.7762/cnr.2022.11.2.133

Cited by 3 publications

(3 citation statements)

References 46 publications

(78 reference statements)

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“…Oral magnesium supplementation increased serum magnesium by a mean of 0.05 mmol/l in our study participants, which is in line with previous reports [ 4 , 28 ]. We used magnesium gluconate because organic magnesium salts have a higher bioavailability than inorganic magnesium salts [ 29 ], as shown in magnesium-depleted rats [ 30 ].…”

Section: Discussionsupporting

confidence: 93%

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial

Drenthen,

de Baaij,

Rodwell

et al. 2023

Diabetologia

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Aims/hypothesis Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium supplementation improves insulin sensitivity in people with type 2 diabetes and a low serum magnesium level is unknown. Methods Using a randomised, double-blind (both participants and investigators were blinded to the participants’ treatment sequences), placebo-controlled, crossover study design, we compared the effect of oral magnesium supplementation (15 mmol/day) for 6 weeks with that of matched placebo in individuals with insulin-treated type 2 diabetes (age ≥18 years, BMI 18–40 kg/m2, HbA1c <100 mmol/mol [11.3%], serum magnesium ≤0.79 mmol/l). Participants were recruited from the outpatient clinic and through advertisements. Randomisation to a treatment sequence order was done using a randomisation list. We used block randomisation and the two possible treatment sequences were evenly distributed among the trial population. The primary outcome was the mean glucose infusion rate during the final 30 min of a hyperinsulinaemic–euglycaemic clamp (i.e. M value). Secondary outcomes included variables of glucose control, insulin need, BP, lipid profile and hypomagnesaemia-related symptoms during follow-up. Results We recruited 14 participants (50% women, 100% White, mean ± SD age 67±6 years, BMI 31±5 kg/m2, HbA1c 58±9 mmol/mol [7.4±0.9%]) with insulin-treated type 2 diabetes. Magnesium supplementation increased both mean ± SEM serum magnesium level (0.75±0.02 vs 0.70±0.02 mmol/l, p=0.016) and urinary magnesium excretion (magnesium/creatinine ratio, 0.23±0.02 vs 0.15±0.02, p=0.005), as compared with placebo. The M value of the glucose clamp did not differ between the magnesium and placebo study arms (4.6±0.5 vs 4.4±0.6 mg kg−1 min−1, p=0.108). During the 6 weeks of treatment, continuous glucose monitoring outcomes, HbA1c, insulin dose, lipid profile and BP also did not differ, except for a lower HDL-cholesterol concentration after magnesium compared with placebo (1.14±0.08 vs 1.20±0.09 mmol/l, p=0.026). Symptoms potentially related to hypomagnesaemia were similar for both treatment arms. Conclusions/interpretation Despite an albeit modest increase in serum magnesium concentration, oral magnesium supplementation does not improve insulin sensitivity in people with insulin-treated type 2 diabetes and low magnesium levels. Trial registration EudraCT number 2021-001243-27. Funding This study was supported by a grant from the Dutch Diabetes Research Foundation (2017–81–014). Graphical Abstract

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Section: Discussionsupporting

confidence: 93%

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial

Drenthen,

de Baaij,

Rodwell

et al. 2023

Diabetologia

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“…Согласно метаанализу 16 РКИ добавки Mg значительно повышали его уровень в сыворотке крови, что могло играть косвенную роль в улучшении клинического состояния пациентов с СД 2 типа [54].…”

Section: эффективность обогащения рациона питания магниемunclassified

The role of magnesium and potassium in preventive and therapeutic nutrition

Погожева

Коденцова

Шарафетдинов

2022

Problems of Nutrition

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Благодаря универсальности своих функций и участию во всех видах обмена веществ магний можно считать основным катионом в организме человека. Не менее важна роль основного внутриклеточного иона -калия, который является синергистом магния, особенно в отношении влияния на функционирование сердечно-сосудистой системы. В России отмечается недостаточное потребление населением магния и калия. 1 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр питания, биотехнологии и безопасности пищи, 109240, г. Москва, Российская Федерация 2 Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет), 119991, г. Москва, Российская Федерация 3 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации, 123242, г. Москва, Российская Федерация

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“…The relationship between magnesium and depression has been examined in previous reports, both with serum magnesium and magnesium dietary intake [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Defining a perfect indicator that appropriately reflects the magnesium status in the human body is challenging.…”

Section: Introductionmentioning

confidence: 99%

The Association of Serum and Dietary Magnesium with Depressive Symptoms

et al. 2023

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Depression is a leading cause of the global burden of disease and has a multifactorial etiology that includes nutrients. Magnesium status has been associated with depression with inconclusive results. The impact of chronic latent magnesium deficiency (CLMD, 0.75 ≤ serum magnesium < 0.85 mmol/L) on depression has not yet been investigated. We assessed the association between serum magnesium levels/dietary magnesium intake and depressive symptoms by analyzing nationally representative data from Taiwan (Nutrition and Health Survey in Taiwan, NAHSIT). We used the 5-item Brief Symptom Rating Scale to measure depressive symptoms. Subgroup analysis by sex was also performed. Serum magnesium levels had a low correlation with dietary magnesium intake. Higher serum magnesium levels were associated with lower depressive scores and a lower risk of depressive symptoms, but dietary magnesium intake showed no association. Sex differences were found. Compared with subjects with serum magnesium <0.75 mmol/L, those with ≥0.85 mmol/L had lower depressive scores. In conclusion, serum magnesium was inversely associated with depressive symptoms, but dietary magnesium intake was not. Subjects with CLMD showed similar depressive scores and were at a similar risk of depressive symptoms to those with serum magnesium < 0.75 mmol/L. CLMD should be considered while assessing the association between magnesium status and depressive symptoms.

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The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 3 publications

References 46 publications

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial

The role of magnesium and potassium in preventive and therapeutic nutrition

The Association of Serum and Dietary Magnesium with Depressive Symptoms

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