The effects of macrophage-derived cytokines on lipid metabolism in chicken (Gallus domesticus) hepatocytes and adipocytes

Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth factor-β

“…Differentiation was character¬ ized by an increase in lipoprotein lipase activity and lipogenesis (Butterwith & Griffin, 1989) TGF-ßl also stimulated [3H]thymidine incorpor¬ ation by about threefold with the maximum at con¬ centrations of 1 pg/1 and an ED50 of 0-34+ 0025 (s.e.m. ; d.f.…”

Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth factor-β

“…Differentiation was character¬ ized by an increase in lipoprotein lipase activity and lipogenesis (Butterwith & Griffin, 1989) TGF-ßl also stimulated [3H]thymidine incorpor¬ ation by about threefold with the maximum at con¬ centrations of 1 pg/1 and an ED50 of 0-34+ 0025 (s.e.m. ; d.f.…”

Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan

“…Costa et al (2014) previously showed that irinotecan induces several inflammatory and oxidative events which precede lipid accumulation in irinotecan-related NASH. In addition, several reports show that inflammation inhibits the lipoprotein lipase in hepatocytes (Butterwith and Griffin, 1989). Inflammation can also lead to excessive production of ROS (Abbas and Lichtman, 2011), damaging mitochondrial membranes.…”

Monokines in Growth and Development

“…However, high levels of human TNF does decrease the rate of hepatic lipogenesis. Interestingly, incubation of chicken adipocytes with LPS-stimulated HD-11 supernatants increases lipogenesis 200% (Butterwith and Griffin, 1989). The monokine-induced increase in chicken adipose lipogenesis is in contrast to murine 3T3-L1 adipocytes whereby TNF or conditioned medium from endotoxin-stimulated macrophages inhibits lipogenesis (Pekala et al, 1983;Patton et al, 1986).…”

Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth factor-β

“…Differentiation was character¬ ized by an increase in lipoprotein lipase activity and lipogenesis (Butterwith & Griffin, 1989) TGF-ßl also stimulated [3H]thymidine incorpor¬ ation by about threefold with the maximum at con¬ centrations of 1 pg/1 and an ED50 of 0-34+ 0025 (s.e.m. ; d.f.…”

Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan

“…Costa et al (2014) previously showed that irinotecan induces several inflammatory and oxidative events which precede lipid accumulation in irinotecan-related NASH. In addition, several reports show that inflammation inhibits the lipoprotein lipase in hepatocytes (Butterwith and Griffin, 1989). Inflammation can also lead to excessive production of ROS (Abbas and Lichtman, 2011), damaging mitochondrial membranes.…”

Monokines in Growth and Development

“…However, high levels of human TNF does decrease the rate of hepatic lipogenesis. Interestingly, incubation of chicken adipocytes with LPS-stimulated HD-11 supernatants increases lipogenesis 200% (Butterwith and Griffin, 1989). The monokine-induced increase in chicken adipose lipogenesis is in contrast to murine 3T3-L1 adipocytes whereby TNF or conditioned medium from endotoxin-stimulated macrophages inhibits lipogenesis (Pekala et al, 1983;Patton et al, 1986).…”

Regulation of DNA synthesis in chicken adipocyte precursor cells by insulin-like growth factors, platelet-derived growth factor and transforming growth factor-β

“…Differentiation was character¬ ized by an increase in lipoprotein lipase activity and lipogenesis (Butterwith & Griffin, 1989) TGF-ßl also stimulated [3H]thymidine incorpor¬ ation by about threefold with the maximum at con¬ centrations of 1 pg/1 and an ED50 of 0-34+ 0025 (s.e.m. ; d.f.…”

Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan

“…Costa et al (2014) previously showed that irinotecan induces several inflammatory and oxidative events which precede lipid accumulation in irinotecan-related NASH. In addition, several reports show that inflammation inhibits the lipoprotein lipase in hepatocytes (Butterwith and Griffin, 1989). Inflammation can also lead to excessive production of ROS (Abbas and Lichtman, 2011), damaging mitochondrial membranes.…”

Monokines in Growth and Development

“…However, high levels of human TNF does decrease the rate of hepatic lipogenesis. Interestingly, incubation of chicken adipocytes with LPS-stimulated HD-11 supernatants increases lipogenesis 200% (Butterwith and Griffin, 1989). The monokine-induced increase in chicken adipose lipogenesis is in contrast to murine 3T3-L1 adipocytes whereby TNF or conditioned medium from endotoxin-stimulated macrophages inhibits lipogenesis (Pekala et al, 1983;Patton et al, 1986).…”