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“…Overall, TXA decreased the incidence of blood loss during cesarean delivery. The relative risk for PPH varied from 0.32 (95% CI: 0.12–0.84) 28 to 0.43 (95% CI: 0.20–0.92) 43 and the odds ratio from 0.17 (95% CI: 0.13–0.22) 44 to 0.39 (95% CI: 0.18–0.85) 24 …”
Section: Resultsmentioning
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“…Overall, TXA decreased the incidence of blood loss during cesarean delivery. The relative risk for PPH varied from 0.32 (95% CI: 0.12–0.84) 28 to 0.43 (95% CI: 0.20–0.92) 43 and the odds ratio from 0.17 (95% CI: 0.13–0.22) 44 to 0.39 (95% CI: 0.18–0.85) 24 …”
Section: Resultsmentioning
“…The therapeutic concentration of tranexamic acid in plasma ranges from 5 mg/kg to 10 mg/kg. After an intravenous dose of 10 mg/kg, plasma concentration was maintained for 3 hours, but in orthopaedics, it was proved to be inadequate (27,28). The 20 mg/kg dose maintains a therapeutic level for 8 hours but increases the risk of a thromboembolic event (19).…”
Section: Methodsmentioning
“…Minimally important effect sizes ranged from an absolute difference of 15% (relative risk (RR) 30%) to 30% (RR 60%) and are consistent with effects observed in many clinical trials of tranexamic acid [ 12 ]. From our systematic review of lysine analogs to prevent bleeding during pelvic surgery, the pooled estimate favored lysine analogs (RR 0.69; 95% confidence interval (CI) 0.47 to 1.00) [ 13 ].…”
Section: Methodsmentioning
“…The infrequent use of lysine analogs during radical cystectomy may be due to lack of high-quality evidence supporting their effectiveness in this setting. While numerous cardiac and orthopedic surgery studies have evaluated the effect of intraoperative lysine analogs [ 12 ], a recent systematic review of major pelvic surgery failed to identify a single cystectomy trial [ 13 ].…”
Section: Introductionmentioning