The effects of lemon balm (<i>Melissa officinalis</i> L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis

Ghazizadeh, Javid; Sadigh-Eteghad, Saeed; Marx, Wolfgang; Fakhari, Ali; Hamedeyazdan, Sanaz; Torbati, Mohammadali; Taheri-Tarighi, Somaiyeh; Araj‐Khodaei, Mostafa; Mirghafourvand, Mojgan

doi:10.1002/ptr.7252

Cited by 23 publications

(7 citation statements)

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“…Interestingly, citrus aurantium L . significantly ameliorated anxiety and did not interfere with physiological levels of melatonin and corticosterone ( 71 ). Thus, it could be reasonably inferred that citrus aurantium L .…”

Section: Discussionmentioning

confidence: 99%

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Tan

Liao

Long

et al. 2023

Front. Public Health

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Background and purposeThe findings of clinical studies exploring essential oils (EOs) for anxiety remain disputed, and no studies have yet clarified the differences in the efficacy of EOs. The purpose of the study was to directly or indirectly compare the efficacy of different types of EOs on anxiety by pooling the results of randomized controlled trials (RCTs).MethodsPubMed, Cochrane Library, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to November 2022. Only full texts of RCTs that investigated the effects of EOs on anxiety were included. The trial data were extracted and the risk of bias was assessed by two reviewers independently. Pairwise meta-analysis and network meta-analysis were performed by Stata 15.1 or R 4.1.2 software.ResultsForty-four RCTs (fifty study arms) involving 10 kinds of EOs and 3419 anxiety patients (1815 patients in EOs group and 1604 patients in control group) were included. Pairwise meta-analyses showed that EOs were effective in reducing State Anxiety Inventory scores (SAIS) [WMD = −6.63, 95% CI−8.17, −5.08] and Trait Anxiety Inventory scores (TAIS) [WMD = −4.97, 95% CI−6.73, −3.20]. Additionally, EOs could decrease systolic blood pressure (SBP) [WMD = −6.83, (95% CI −10.53, −3.12), P < 0.001] and heart rate (HR) [WMD = −3.43, (95% CI −5.51, −1.36), P < 0.001]. Network meta-analyses demonstrated that regarding the outcome of SAIS, Jasminum sambac (L.)Ait. (jasmine) was the most effective with a weighted mean difference (WMD) of−13.61 (95% CrI−24.79, −2.48). Followed by Citrus (citrus aurantium L.), which had a WMD of−9.62 (95% CrI−13.32, −5.93). Moderate effect sizes were observed for Rosa rugosa Thunb. (damask rose) (WMD = −6.78, 95% CrI−10.14, −3.49) and Lavandula angustifolia Mill. (lavender) (WMD = −5.41, 95% CrI−7.86, −2.98). Regarding the results of TAIS, citrus aurantium L. was the best ranked intervention with a WMD of−9.62 (95% CrI−15.62, −3.7). Moderate-to-large effect sizes were observed for Citrus limon (L.) Burm. F. (lemon) (WMD:−8.48; 95% CrI−16.67, −0.33) and lavender (WMD:−5.5; 95% CrI−8.7, −2.46).ConclusionAccording to the comprehensive analysis, EOs are effective in reducing both state anxiety and trait anxiety, and citrus aurantium L. essential oil seems to be the most recommended type of EO for treating anxiety because of its significant effects in reducing SAIS and TAIS.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022331319.

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Section: Discussionmentioning

confidence: 99%

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Tan

Liao

Long

et al. 2023

Front. Public Health

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“…37,38 Moaca et al studies concluded that rosmarinic acid (RA) a well-known phenolic compound from M. officinalis was responsible for the plants antimigratory effects. 39,40 Jahanban-Esfahlan et al evaluated the anti-tumor effect of Lemon balm different extracts, on H460 and two other cancer cell lines; reporting the ethanol extract as the most effective, and H460 cell line as the most affected cells. 35 They concluded that M. officinalis dose-dependently affected the cell cycle profile of H460 cells.…”

Section: Melissa Officinalismentioning

confidence: 99%

Promising leads against lung cancer from the plants in Lamiaceae family

Rahimlouy Aghdam,

Hamedeyazdan

2024

Bioimpacts

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Introduction: Ceaselessly, management of cancer has been the major global challenge for healthcare professionals. As regards, lung cancer (LC) has been introduced as the second most common form of cancer in both men and women, taking the lives of more than a million people each year, statistically holding the highest mortality rate among all cancer types. Although much effort has been made for the management of LC, current therapies are quite ineffective. With reference to the fact that the most current chemotherapeutic agents for LC are of plant origin, the authors hereby collected the acclaimed plants from the Lamiaceae family which have shown remarkable activity against LC. Methods: The incorporated papers were published between the years of 1997 and 2023. The principal search keywords for this review article were "lung cancer", "Lamiaceae", "cytotoxic effect", "anti-tumor" and "anti-proliferative" in Medline, Springer, Scopus, ScienceDirect and Google Scholar databases. Results: To the furthest extent, different responsible mechanism(s) of action for the anti-cancer properties of each plant are discussed. The respected IC50 values for plant extracts, essential oils or pure isolated compounds are underlined as well. Conclusion: Many plants and isolated relative phytochemicals have shown exceptional anti-cancer potency against LC; nonetheless, they still remain undisclosed. We believe that this assembled data would globally inspire scientists on the passing way of LC treatment.

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“…Specifically, St. John's Wort alters Melissa officinalis L. is a medicinal plant traditionally used in various ethno-medical systems, particularly in Traditional European Medicine and Traditional Iranian Medicine for the treatment of various diseases. It is also widely used as a vegetable and to flavor dishes [56]. Biological studies have shown that essential oil and extracts of lemon balm have natural components capable of determining pharmacological effects with potential clinical uses.…”

Section: Drug-natural Compound Interactions: Cyp3a4 Inhibitionmentioning

confidence: 99%

Toxicity Derived from Interaction between Natural Compounds and Cancer Therapeutic Drugs Metabolized by CYP3A4: Lessons Learned from Two Clinical Case Reports

Orzetti,

Baldo

2023

IJMS

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The use of natural compounds and, in general, the use of Complementary and Alternative Medicine (CAM), is growing steadily worldwide, both due to commercial pressure and the increasing use of self-medication and the desire to manage one’s own personal health and well-being. Patients facing a cancer diagnosis are also strongly pressured to use these compounds, which are often added to standard therapeutic regimens, that should instead be based solely on diagnostic and therapeutic care pathways (DTCP) or evidence-based medicine (EBM). This study presents two clinical cases of cancer patients who presented to the pharmaceutical consultation service (PCD—Pharmacy Clinical Desk) established at the CRO Institute in Aviano, Italy. Both patients were using natural products along with prescribed chemotherapy. In the first case, a 55-year-old woman diagnosed with bilateral breast cancer with bone metastases, who was using natural compounds based on diosmin, escin (or aescin) and resveratrol in combination with ribociclib anticancer therapy, a severe ADR (neutropenia) was identified as a consequence of the drug–natural product interaction. In the second case, following a detailed medication review by the PCD, we avoided taking a therapeutic treatment (with natural compounds) that in itself could potentially render chemotherapy ineffective in a 57-year-old woman with multiple infiltrating ductal carcinoma of the left breast; the patient was planning to take a natural product containing St. John’s Wort tincture and lemon balm tincture, in combination with paclitaxel and trastuzumab. In addition, we describe the corrective actions taken, thus outlining the main objectives of the activity of the PCD’s pharmacy counseling service: first, to identify, report, and manage adverse drug reactions (ADRs), and second, to identify therapeutic combinations that present potential risks of toxicity or ineffectiveness of the drug therapy itself.

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The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta‐analysis

Cited by 23 publications

References 62 publications

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis

Promising leads against lung cancer from the plants in Lamiaceae family

Toxicity Derived from Interaction between Natural Compounds and Cancer Therapeutic Drugs Metabolized by CYP3A4: Lessons Learned from Two Clinical Case Reports

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