The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat

Wardley‐Smith, Bridget

doi:10.1016/0028-3908(89)90066-x

Neuropharmacology

1989

DOI: 10.1016/0028-3908(89)90066-x

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The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat

Bridget Wardley‐Smith¹

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Cited by 5 publications

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Effects of kynurenine metabolites on the electrocorticographic activity in the rat

Yokoi

Nishijima

Uchida

et al. 1998

Journal of Neural Transmission

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We examined the effects of kynurenine metabolites administered into the right cerebroventricle (1 micromol) on the electrocorticogram (ECoG) of rats to establish the role of kynurenines on brain function. Kynurenine, anthranilic acid, quinaldic acid, xanthurenic acid or 8-hydroxyquinaldic acid showed no effect on ECoG throughout the recording period of 4 hours. 3-Hydroxykynurenine had a transient suppressive effect on the ECoG, while kynurenic acid caused a slight suppression of ECoG activity. 3-Hydroxyanthranilic acid (3-OH-An), a metabolite of 3-hydroxykynurenine, induced spike discharges with a long latency (60-230 min). 3-OH-An is thought to be metabolized to o-aminophenol, 3-methoxyanthranilic acid, quinolinic acid, 2-ketoadipic acid and picolinic acid. Among 3-OH-An metabolites, only o-aminophenol induced spike discharges several minutes after administration, lasting for 60 min. On the other hand, quinolinic acid suppressed ECoG, though 3-methoxyanthranilic acid, 2-ketoadipic acid and picolinic acid had no effects on ECoG. These electrocorticographic findings suggest that 3-OH-An may induce spike discharges after it is metabolized in the brain to o-aminophenol.

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Effects of kynurenine metabolites on the electrocorticographic activity in the rat

Yokoi

Nishijima

Uchida

et al. 1998

Journal of Neural Transmission

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Psychopharmacological effects of acute exposure to kynurenic acid (KYNA) in zebrafish

Robinson

Stewart

Cachat

et al. 2013

Pharmacology Biochemistry and Behavior

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Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

Stone

2001

Progress in Neurobiology

277

200

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The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat

Cited by 5 publications

References 28 publications

Effects of kynurenine metabolites on the electrocorticographic activity in the rat

Effects of kynurenine metabolites on the electrocorticographic activity in the rat

Psychopharmacological effects of acute exposure to kynurenic acid (KYNA) in zebrafish

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

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