The Effects of Iv Propofol and Iv Thiopentone as Induction Agents on Blood Glucose in Elective Surgeries Under General Anaesthesia- A Prospective Double-Blind Randomised Study

Abstract

BACKGROUND Acute hyperglycaemia in peri-operative period is associated with significantly increased organ specific complications. Acute hyperglycaemia during surgery worsens prognosis even in the patients who had normal glucose tolerance test. In few studies the effects of propofol and thiopentone were compared. In this study, we evaluated the effect of Propofol and Thiopentone on blood glucose during elective surgeries done under general anaesthesia in non-diabetic patients. MATERIALS AND METHODS After approval by the institutional ethical committee and oral informed consent, 60 patients aged between 20 years and 60 years, ASA 1 and 2 who underwent elective surgeries under general anaesthesia were studied in this double blind, prospective, randomized comparative study. This study was conducted to compare the effects of anaesthetic induction with single dose propofol versus thiopentone on blood glucose and haemodynamics. RESULTS The mean difference in blood sugar between propofol and thiopentone groups is not statistically significant. (t=1.003, df=54, p=0.320).There was no significant increase in heart rate, systolic blood pressure, diastolic blood pressure & mean arterial pressure at T5 & T15 in both the groups. CONCLUSION From the observations and results of the study, we conclude that I.V. propofol and I.V. thiopentone prevent hyperglycaemia when values were compared with basal readings. Haemodynamic parameters were not statistically significant in both the groups.