The Effects Of Hydro- Ethanolic Extract Of Euphorbia Hirta Leaves Extract On Hemato-Biochemical Changes In Cigarette Smoke-Exposed Rats

Abstract

Cigarette smoke is a source of free radicals that cause health problems throughout the world. The study aimed to determine the effects of hydro-ethanolic extract of Euphorbia hirta leaves extract (EHLE) on hemato-biochemical changes in cigarette smoke exposed (CSE) rats. The study using 24 male Wistar rats consisted of Control (not exposed to cigarette smoke and given distilled water), group II Diseased group (cigarette smoke and given distilled water), group III treated group (Cigarette smoke and Euphorbia hirta leaves extract 200 mg/kg BW) and group IV plant alone (Euphorbia hirta leaves extract 200 mg/kg BW alone). Exposure to cigarette smoke and administration of extracts was carried out for 12 weeks. End of the experimental period, the rats were euthanized and dissected to collect the blood for hematobiochemical studies. The results of the study showed that treatment with Euphorbia hirta leaves extract to CSE rats restored the hematological parameters, liver and kidney markers.