2015
DOI: 10.18632/oncotarget.4142
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Faced with reduced levels of food, animals must adjust to the consequences of the shortfall in energy. We explored how C57BL/6 mice withdrew energy from different body tissues during three months of food restriction at graded levels up to 40% (calorie restriction: CR). We compared this to the response to equivalent levels of protein restriction (PR) without a shortfall in calories. Under CR there was a dynamic change in body mass over 30 days and thereafter it stabilized. The time to reach stability was indepe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

17
142
2

Year Published

2015
2015
2023
2023

Publication Types

Select...
6
1

Relationship

3
4

Authors

Journals

citations
Cited by 88 publications
(161 citation statements)
references
References 78 publications
17
142
2
Order By: Relevance
“…Additionally, we correlated these metabolites with physiological data (Mitchell et al ., 2015a,c, 2016a). S1P and sphingomyelin were negatively correlated with body mass (S1P r  = −0.761, P  < 0.001 and SM r  = −0.453, P  = 0.019) and positively correlated with food anticipatory activity (activity in the 2 h before food supply: FAA) (S1P r  = 0.771, P  < 0.001 and SM r  = 0.365, P  = 0.024), whereas ceramide correlated in the opposite direction (BM r  = 0.550, P  = 0.003 and FAA r  = −0.412, P  = 0.015).…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Additionally, we correlated these metabolites with physiological data (Mitchell et al ., 2015a,c, 2016a). S1P and sphingomyelin were negatively correlated with body mass (S1P r  = −0.761, P  < 0.001 and SM r  = −0.453, P  = 0.019) and positively correlated with food anticipatory activity (activity in the 2 h before food supply: FAA) (S1P r  = 0.771, P  < 0.001 and SM r  = 0.365, P  = 0.024), whereas ceramide correlated in the opposite direction (BM r  = 0.550, P  = 0.003 and FAA r  = −0.412, P  = 0.015).…”
Section: Resultsmentioning
confidence: 99%
“…We have previously shown that liver mass decreases by 17.5, 27.6, 25.6 and 27.7% at restriction levels of 10, 20, 30 and 40%, respectively, relative to the 12AL control (Mitchell et al ., 2015c). These losses were significant between 12AL and the CR groups, but not between CR groups.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Male mice were aged 20 weeks when they entered four levels of CR for 12 weeks: 10%, 20%, 30%, and 40% restriction from baseline food intake (Mitchell et al., 2015). Two control groups, 12‐ and 24‐hr ad libitum access to food (12AL and 24AL, respectively), were used, and statistical analysis was calculated using 24AL as reference.…”
Section: Introductionmentioning
confidence: 99%
“…Something worth noting is that when we recorded the changes in sizes of the different organs, the alimentary tract was completely protected (and even grew a little) when compared with other organs (Mitchell et al., 2015). Clearly different organs respond very differently to the CR intervention and this may be also true for the senescence phenotype, and hence, also other features like wound healing.…”
Section: Introductionmentioning
confidence: 99%