volume 9, issue 7, P1770-1824 2017
DOI: 10.18632/aging.101269
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Davina Derous, Sharon E. Mitchell, Lu Wang, Cara L. Green, Yingchun Wang, Luonan Chen, Jing-Dong J. Han, Daniel E.L. Promislow, David Lusseau, Alex Douglas, John R. Speakman

Abstract: Calorie restriction (CR) may extend longevity by modulating the mechanisms involved in aging. Different hypotheses have been proposed for its main mode of action. We quantified hepatic transcripts of male C57BL/6 mice exposed to graded levels of CR (0% to 40% CR) for three months, and evaluated the responses relative to these various hypotheses. Of the four main signaling pathways implied to be linked to the impact of CR on lifespan (insulin/insulin like growth factor 1 (IGF-1), nuclear factor-kappa beta (NF-ĸ…

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