2015
DOI: 10.18632/oncotarget.4003
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Limiting food intake attenuates many of the deleterious effects of aging, impacting upon healthspan and leading to an increased lifespan. Whether it is the overall restriction of calories (calorie restriction: CR) or the incidental reduction in macronutrients such as protein (protein restriction: PR) that mediate these effects is unclear. The impact of 3 month CR or PR, (10 to 40%), on C57BL/6 mice was compared to controls fed ad libitum. Reductions in circulating leptin, tumor necrosis factor-α and insulin-li… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

16
115
1

Year Published

2015
2015
2021
2021

Publication Types

Select...
6
2

Relationship

1
7

Authors

Journals

citations
Cited by 76 publications
(132 citation statements)
references
References 151 publications
16
115
1
Order By: Relevance
“…To explore the metabolites that had a graded response further, we correlated them (Pearson's correlation) with circulating hormone levels (Table S3), major urinary proteins (MUPs) and markers of oxidative stress (Table S4), measures of which are detailed in our previous paper (Mitchell et al ., 2015b). We found that circulating levels of leptin correlated negatively with S1P and sphingomyelin (SM) and positively with ceramide (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…To explore the metabolites that had a graded response further, we correlated them (Pearson's correlation) with circulating hormone levels (Table S3), major urinary proteins (MUPs) and markers of oxidative stress (Table S4), measures of which are detailed in our previous paper (Mitchell et al ., 2015b). We found that circulating levels of leptin correlated negatively with S1P and sphingomyelin (SM) and positively with ceramide (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…4A). Leptin was reduced with increasing levels of restriction and was strongly positively correlated with adiposity (Mitchell et al ., 2015b). As leptin is a key regulator of long‐term energy balance, its reduction during CR may be antagonistically regulating S1P and ceramide (Rosen & Spiegelman, 2006).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Johnston et al [58] tested this concept by placing mice on calorie-restricted or high-fat diets and found that calorically restricted female mice were "having it all" -both greater fecundity and longer lifespan. Interestingly, CR in male mice appears to reduce major urinary proteins [59] and thus investment into reproduction, which may confer reproductive success by driving scent marking and thus possibly pointing to decreasing fecundity [59] .…”
Section: Energy Metabolism and Ageing In The Mousementioning
confidence: 99%
“…In more recent years, randomized control trials, which generally reduce caloric intake by 20 -30% for 6 -12 mo, have observed reductions in circulating insulin, leptin, and TNF␣/adiponectin ratio as well as reduced quantity of visceral and subcutaneous fat (27,63,78,80). In rodents, the quantity of circulating leptin, TNF␣, and insulin-like growth factor I are negatively correlated to the extent of CR (10 -40% reduction) (53). In contrast, corticosterone, which increases in response to 25% CR, is not increased any further by a 50% CR (38).…”
Section: Metabolic Impact Of Crmentioning
confidence: 99%