2016
DOI: 10.18632/aging.100944
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Abstract: Connectivity in a gene-gene network declines with age, typically within gene clusters. We explored the effect of short-term (3 months) graded calorie restriction (CR) (up to 40 %) on network structure of aging-associated genes in the murine hypothalamus by using conditional mutual information. The networks showed a topological rearrangement when exposed to graded CR with a higher relative within cluster connectivity at 40CR. We observed changes in gene centrality concordant with changes in CR level, with Pparg… Show more

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Cited by 18 publications
(19 citation statements)
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References 85 publications
(151 reference statements)
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“…For example, on a DR diet, metabolite correlation networks are still largely intact in older flies, but not in flies on an AL diet [35] (see also Figure 2). A similar effect of DR on transcriptional network connectivity is also observed in worms [107] and mice [100]. Together, these studies indicate that lifespan extending interventions may have a significant influence on network stability.…”
Section: Cellular Network Stability and Ageingsupporting
confidence: 66%
“…This systems biology approach allows us to explore the possibility that the process of ageing might be affected in fundamental ways by age-related changes in network structure. In this case, rather than looking at changes in concentrations of individual genes, proteins, and metabolites, the suggestion is that changes in cross-talk between biochemical building blocks play an equally or more important role [35,95,97100]. This network-based framework allows us to understand a more complete picture of the biological mechanisms that influence ageing, age-related diseases, and longevity.…”
Section: Cellular Network Stability and Ageingmentioning
confidence: 99%
See 1 more Smart Citation
“…We know now that this level of CR may be excessive for some strains of mice. The interaction between the degree of CR and different aspects of physiology has been recently examined (Derous et al, 2016a; Derous et al, 2016b; Lusseau et al, 2015; Mitchell et al, 2015a; Mitchell et al, 2016a; Mitchell et al, 2015b; Mitchell et al, 2015c) and survival (Mitchell et al, 2016b). …”
Section: Genotype and Gender Influences On Crmentioning
confidence: 99%
“…Efforts are now invested to further investigated this interplay between mouse strains, the level of restriction, and their impact on survival. The DBA results of Mitchell et al (2016) and those from John Speakman’s group in which the effects of different grades of CR in B6 mice elicit differential responses (Derous et al, 2016a; Derous et al, 2016b; Lusseau et al, 2015; Mitchell et al, 2015a; Mitchell et al, 2016a; Mitchell et al, 2015b; Mitchell et al, 2015c) open the door for new studies aimed at identify the underlying biological responses. Thus, one could predict that some of the recombinant inbred strains will have a beneficial response to CR if they were tested at a lower level of dietary restriction.…”
Section: Genotype and Gender Influences On Crmentioning
confidence: 99%